MicroRNA-21 promotes osteogenic differentiation of mesenchymal stem cells by the PI3K/β-catenin pathway

Journal of Orthopaedic Research

Volumn 33, Issue 7, 2015, Pages 957-964

  Meng, Yu Bin ^a   Li, Xue ^b   Li, Zhao Yang ^a   Zhao, Jin ^a   Yuan, Xu Bo ^a   Ren, Yu ^b   Cui, Zhen Duo ^a   Liu, Yun De ^b   Yang, Xian Jin ^a  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

mesenchymal stem cells; miR 21; osteogenesis; PI3K AKT catenin

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; MICRORNA 21; OSTEOCALCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR RUNX2; MICRORNA; MIRN21 MICRORNA, HUMAN;

ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; ENZYME PHOSPHORYLATION; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY;

BETA CATENIN; CELL DIFFERENTIATION; HUMANS; MESENCHYMAL STROMAL CELLS; MICRORNAS; OSTEOGENESIS; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION;

EID: 84930085644     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22884     Document Type: Article

References (31)

1. Robey PG, Kuznetsov SA, Ren J, et al., 2015. Generation of clinical grade human bone marrow stromal cells for use in bone regeneration. Bone 70: 87-92.
2. Knight MN, Hankenson KD,. 2013. Mesenchymal stem cells in bone regeneration. Adv Wound Care (New Rochelle) 2: 306-316.
3. Bai Y, Yin G, Huang Z, et al., 2013. Localized delivery of growth factors for angiogenesis and bone formation in tissue engineering. Int Immunopharmacol 16: 214-223.
4. Lian JB, Stein GS, van Wijnen AJ, et al., 2012. MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol 8: 212-227.
5. Ghildiyal M, Zamore PD,. 2009. Small silencing RNAs: an expanding universe. Nat Rev Genet 10: 94-108.
6. Hu R, Liu W, Li H, et al., 2011. A RUNX2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem 286: 12328-12339.
7. Li Z, Hassan MQ, Jafferji M, et al., 2009. Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem 284: 15676-15684.
8. Chen J, Crawford R, Chen C, et al., 2013. The key regulatory roles of the PI3K/AKT signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration. Tissue Eng Part B Rev 19: 516-528.
9. Williams BO, Insogna KL,. 2009. Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. J Bone Miner Res 24: 171-178.
10. Peng XD, Xu PZ, Chen ML, et al., 2003. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking AKT1 and AKT2. Genes Dev 17: 1352-1365.
11. Mukherjee A, Wilson EM, Rotwein P., 2010. Selective signaling by AKT2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation. Mol Cell Biol 30: 1018-1027.
12. Zhang KL, Han L, Chen LY, et al., 2014. Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. Cancer Lett 342: 139-149.
13. Kawakita A, Yanamoto S, Yamada SI, et al., 2013. MicroRNA-21 promotes oral cancer invasion via the Wnt/beta-catenin pathway by targeting DKK2. Pathol Oncol Res 20: 253-261.
14. Eguchi T, Watanabe K, Hara ES, et al., 2013. OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cells. PLoS ONE 8: e58796.
15. Mei Y, Bian C, Li J, et al., 2013. miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation. J Cell Biochem 114: 1374-1384.
16. Yang N, Wang G, Hu C, et al., 2013. Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis. J Bone Miner Res 28: 559-573.
17. Duya P, Bian Y, Chu X, et al., 2013. Stem cells for reprogramming: could hUMSCs be a better choice ? Cytotechnology 65: 335-345.
18. Yuan H, Zhuang Y, Xiong J, et al., 2013. Human umbilical mesenchymal stem cells-seeded bladder acellular matrix grafts for reconstruction of bladder defects in a canine model. PLoS ONE 8: e80959.
19. Lu LL, Liu YJ, Yang SG, et al., 2006. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica 91: 1017-1026.
20. Subramanian A, Shu-Uin G, Kae-Siang N, et al., 2012. Human umbilical cord Wharton's jelly mesenchymal stem cells do not transform to tumor-associated fibroblasts in the presence of breast and ovarian cancer cells unlike bone marrow mesenchymal stem cells. J Cell Biochem 113: 1886-1895.
21. Dalous J, Larghero J, Baud O., 2012. Transplantation of umbilical cord-derived mesenchymal stem cells as a novel strategy to protect the central nervous system: technical aspects, preclinical studies, and clinical perspectives. Pediatr Res 71: 482-490.
22. Drosse I, Volkmer E, Capanna R, et al., 2008. Tissue engineering for bone defect healing: an update on a multi-component approach. Injury 39: S9-S20.
23. Baksh D, Yao R, Tuan RS,. 2007. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 25: 1384-1392.
24. Hua J, Gong J, Meng H, et al., 2013. Comparison of different methods for the isolation of mesenchymal stem cells from umbilical cord matrix: proliferation and multilineage differentiation as compared to mesenchymal stem cells from umbilical cord blood and bone marrow. Cell Biol Int 38: 198-210.
25. Gamie Z, Tran GT, Vyzas G, et al., 2012. Stem cells combined with bone graft substitutes in skeletal tissue engineering. Expert Opin Biol Ther 12: 713-729.
26. Guntur AR, Rosen CJ,. 2011. The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase. J Endocrinol 211: 123-130.
27. Zhang JG, Wang JJ, Zhao F, et al., 2010. MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta 411: 846-852.
28. Ren W, Qiang C, Gao L, et al., 2014. Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma. Biomarkers 1: 1-7.
29. Xu LF, Wu ZP, Chen Y, et al., 2014. MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma. PLoS ONE 9: e103698.
30. Lee HW, Ha SY, Roh MS,. 2014. Altered expression of PTEN and its major regulator MicroRNA-21 in pulmonary neuroendocrine tumors. Korean J Pathol 48: 17-23.
31. Kumar A, Rajendran V, Sethumadhavan R., 2013. AKT kinase pathway: a leading target in cancer research. ScientificWorldJournal 2013: 756134.