Nationwide reduction in the frequency of severe hypoglycemia by half

Acta Diabetologica

Volumn 52, Issue 3, 2015, Pages 591-599

  Fredheim, S ^a,b   Johansen, A ^c   Thorsen, S U ^a,b   Kremke, B ^d   Nielsen, L B ^a   Olsen, B S ^a   Lyngsoe L ^e   Sildorf, S M ^a   Pipper, C ^b   Mortensen, H B ^a,b   Johannesen, J ^a,b   Svensson, J ^a,b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Rigshospitalet   (Denmark)

^d RANDERS REGIONAL HOSPITAL   (Denmark)

^e HILLERØD HOSPITAL   (Denmark)

Author keywords

Children; Hypoglycemia; Insulin therapy; Register; Type 1 diabetes

Indexed keywords

HEMOGLOBIN A1C; HUMAN INSULIN; INSULIN ASPART; INSULIN DETEMIR; INSULIN GLARGINE; INSULIN GLULISINE; INSULIN LISPRO; ISOPHANE INSULIN; INSULIN;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; DENMARK; DISEASE DURATION; FEMALE; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN PUMP; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SEVERE HYPOGLYCEMIA; DIABETES MELLITUS, TYPE 1; PRESCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DENMARK; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; HYPOGLYCEMIA; INSULIN; MALE;

EID: 84930081623     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-014-0697-5     Document Type: Article

References (25)

1. McCoy RG, Van Houten HK, Ziegenfuss JY, Shah ND, Wermers RA, Smith SA (2012) Increased mortality of patients with diabetes reporting severe hypoglycemia. Diabetes Care 35(9):1897–1901
2. Cryer PE (2010) Hypoglycemia in type 1 diabetes mellitus. Endocrinol Metab Clin North Am [Internet] 39(3):641–54. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2923455&tool=pmcentrez&rendertype=abstract
3. Nathan DM, Cleary PA, Backlund J-YC, Genuth SM, Lachin JM, Orchard TJ et al (2005) Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353(25):2643–2653
4. White NH, Cleary PA, Dahms W, Goldstein D, Malone J, Tamborlane WV et al (2001) Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT). J Pediatr 139(6):804–812
5. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med (1993) 329(14):977–86
6. Bulsara MK, Holman CDJ, Davis EA, Jones TW (2004) The impact of a decade of changing treatment on rates of severe hypoglycemia in a population-based cohort of children with type 1 diabetes. Diabetes Care 27(10):2293–2298
7. O’Connell SM, Cooper MN, Bulsara MK, Davis EA, Jones TW (2011) Reducing rates of severe hypoglycemia in a population-based cohort of children and adolescents with type 1 diabetes over the decade 2000–2009. Diabetes Care 34(11):2379–2380
8. Pickup JC, Sutton AJ (2008) Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabet Med J Br Diabet Assoc 25(7):765–774
9. Karges B, Rosenbauer J, Kapellen T, Wagner VM, Schober E, Karges W et al (2014) Hemoglobin A1c levels and risk of severe hypoglycemia in children and young adults with type 1 diabetes from Germany and Austria: a trend analysis in a cohort of 37,539 patients between 1995 and 2012. PLoS Med 11(10):e1001742
10. Wagner VM, Rosenbauer J, Grabert M, Holl RW (2008) German initiative on quality control in pediatric diabetology. Severe hypoglycemia, metabolic control, and diabetes management in young children with type 1 diabetes using insulin analogs–a follow-up report of a large multicenter database. Eur J Pediatr 167(2):241–242
11. Johansen A, Kanijo B, Fredheim S, Olsen B, Hertz B, Lauridsen M, Andersen M, Mortensen H, Svensson J, the Danish Society for Diabetes in Childhood (2014) Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes. Pediatr Diabetes. doi:10.1111/pedi.12171
12. Clarke W, Jones T, Rewers A, Dunger D, Klingensmith GJ (2008) Assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes 9(2):165–174
13. Surveillance WHOD of ND. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. http://apps.who.int/iris/handle/10665/66040
14. Svensson J, Marinelli K, Eising S (2007) Danish childhood diabetes register, national discharge register. [Comparison of registration of data from the Danish childhood diabetes register and the national discharge register]. Ugeskr Laeger 169(2):122–125
15. Bangstad H-J, Danne T, Deeb LC, Jarosz-Chobot P, Urakami T, Hanas R et al (2007) ISPAD clinical practice consensus guidelines 2006–2007. Insulin treatment Pediatr Diabetes 8(2):88–102
16. Swift PGF (2007) International society for pediatric and adolescent diabetes. ISPAD clinical practice consensus guidelines 2006–2007. Diabetes education. Pediatr Diabetes 8(2):103–109
17. Nørgaard Kirsten, Olsen Birthe (2011) Changing Denmark from a non-user country to a place using insulin pumps: a story on the initiatives taken. Infusystems Int 10(4):25–29
18. Cooper MN, O’Connell SM, Davis EA, Jones TW (2013) A population-based study of risk factors for severe hypoglycaemia in a contemporary cohort of childhood-onset type 1 diabetes. Diabetologia [Internet] http://www.ncbi.nlm.nih.gov/pubmed/23832082
19. Ly TT, Nicholas JA, Retterath A, Lim EM, Davis EA, Jones TW (2013) Effect of sensor-augmented insulin pump therapy and automated insulin suspension vs standard insulin pump therapy on hypoglycemia in patients with type 1 diabetes: a randomized clinical trial. JAMA 310(12):1240–1247
20. Bergenstal RM, Tamborlane WV, Ahmann A, Buse JB, Dailey G, Davis SN et al (2011) Sensor-augmented pump therapy for A1C reduction (STAR 3) study: results from the 6-month continuation phase. Diabetes Care 34(11):2403–2405
21. Peterson A, Hanberger L, Akesson K, Bojestig M, Andersson Gäre B, Samuelsson U (2014) Improved results in paediatric diabetes care using a quality registry in an improvement collaborative: a case study in Sweden. PLoS One 9(5):e97875
22. Hershey T, Lillie R, Sadler M, White NH (2004) A prospective study of severe hypoglycemia and long-term spatial memory in children with type 1 diabetes. Pediatr Diabetes 5(2):63–71
23. Holemans X, Dupuis M, Misson N, Vanderijst JF (2001) Reversible amnesia in a Type 1 diabetic patient and bilateral hippocampal lesions on magnetic resonance imaging (MRI). Diabet Med J Br Diabet Assoc 18(9):761–763
24. Pickup JC, Freeman SC, Sutton AJ (2011) Glycaemic control in type 1 diabetes during real time continuous glucose monitoring compared with self monitoring of blood glucose: meta-analysis of randomised controlled trials using individual patient data. BMJ 343:d3805
25. Choudhary P, Ramasamy S, Green L, Gallen G, Pender S, Brackenridge A et al (2013) Real-time continuous glucose monitoring significantly reduces severe hypoglycemia in hypoglycemia-unaware patients with type 1 diabetes. Diabetes Care 36(12):4160–4162