A randomized trial comparing concurrent chemoradiotherapy with single-agent cisplatin versus cisplatin plus gemcitabine in patients with advanced cervical cancer: An Asian Gynecologic Oncology Group study

Gynecologic Oncology

Volumn 137, Issue 3, 2015, Pages 462-467

  Wang, Chun Chieh ^a,b   Chou, Hung Hsueh ^a,b   Yang, Lan Yan ^b,c   Lin, Hao ^a,b   Liou, Wen Shiung ^d   Tseng, Chih Wen ^a   Liu, Feng Yuan ^a,b   Liou, Jui Der ^a,b   Huang, Kuan Gen ^a,b   Huang, Huei Jean ^a,b   Huang, Eng Yen ^a   Chen, Chien Hsun ^d   Chang, Ting Chang ^a,b   Chang, Chee Jen ^c,e   Hong, Ji Hong ^a,b   Lai, Chyong Huey ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c Asian Gynecologic Oncology Group   (Taiwan)

^d KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Cervical cancer; Chemoradiotherapy; Cisplatin; Gemcitabine; Squamous cell carcinoma

Indexed keywords

CISPLATIN; GEMCITABINE; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE;

ADD ON THERAPY; ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANOREXIA; ARTICLE; CANCER STAGING; CHEMORADIOTHERAPY; CHEMOTHERAPY INDUCED ANEMIA; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; COMPARATIVE STUDY; CONTROLLED STUDY; DIARRHEA; DISTANT METASTASIS; DRUG SAFETY; FATIGUE; FEMALE; FOLLOW UP; HUMAN; INTERMETHOD COMPARISON; LEUKOPENIA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OPEN STUDY; OVERALL SURVIVAL; PARAAORTIC LYMPH NODE; PATIENT COMPLIANCE; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SKIN DISEASE; STOMATITIS; THROMBOCYTOPENIA; TREATMENT RESPONSE; UTERINE CERVIX CANCER; WEIGHT REDUCTION; ANALOGS AND DERIVATIVES; CARCINOMA, SQUAMOUS CELL; CLINICAL TRIAL; DISEASE FREE SURVIVAL; MIDDLE AGED; PATHOLOGY; PROCEDURES; UTERINE CERVICAL NEOPLASMS;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY; CISPLATIN; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; MIDDLE AGED; UTERINE CERVICAL NEOPLASMS;

EID: 84930046226     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2015.03.046     Document Type: Article

References (22)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global Cancer Statistics CA Cancer J. Clin. 61 2011 69 90
2. P.G. Rose Concurrent chemoradiation for locally advanced carcinoma of the cervix: where are we in 2006? Ann. Oncol. 17 Suppl. 10 2006 x224 x229
3. M. Markman Chemoradiation in the management of cervix cancer: current status and future directions Oncology 84 2013 246 250
4. P.G. Rose, B.N. Bundy, and E.B. Watkins Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer N. Engl. J. Med. 340 1999 1144 1153
5. C.W. Whitney, W. Sause, and B.N. Bundy Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study J. Clin. Oncol. 17 1999 1339 1348
6. P.J. Eifel, K. Winter, and M. Morris Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01 J. Clin. Oncol. 22 2004 872 880
7. T.H. Doyle, F. Mornex, and W.G. McKenna The clinical implications of gemcitabine radiosensitization Clin. Cancer Res. 7 2001 226 228
8. J. Carmichael The role of gemcitabine in the treatment of other tumours Br. J. Cancer 78 Suppl. 3 1998 21 25
9. R.J. Schilder, J. Blessing, and D.E. Cohn Evaluation of gemcitabine in patients with squamous cell carcinoma of the cervix: a phase II study of the gynecologic oncology group Gynecol. Oncol. 76 2000 204 207
10. V. Lorvidhaya, P. Kamnerdsupaphon, I. Chitapanarux, V. Sukthomya, and A. Tonusin Cisplatin and gemcitabine in patients with metastatic cervical cancer Gan To Kagaku Ryoho 31 2004 1057 1062
11. J. Umanzor, M. Aguiluz, and C. Pineda Concurrent cisplatin/gemcitabine chemotherapy along with radiotherapy in locally advanced cervical carcinoma: a phase II trial Gynecol. Oncol. 100 2006 70 75
12. A. Duenas-Gonzalez, J.J. Zarbá, and F. Patel Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix J. Clin. Oncol. 29 2011 1678 1685
13. T.C. Yen, L.C. See, and C.H. Lai Standardized uptake value in para-aortic lymph node is a significant prognostic factor in primary advanced squamous cervical cancer Eur. J. Nucl. Med. Mol. Imaging 35 2008 493 501
14. C.S. Tsai, C.H. Lai, and T.C. Chang A prospective randomized trial to study the impact of pretreatment FDG-PET for cervical cancer patients with MRI-detected positive pelvic but negative para-aortic lymphadenopathy Int. J. Radiat. Oncol. Biol. Phys. 76 2010 477 484
15. J.H. Hong, C.S. Tsai, and C.H. Lai Risk stratification of patients with advanced squamous cell carcinoma of cervix treated by radiotherapy alone Int. J. Radiat. Oncol. Biol. Phys. 63 2005 492 499
16. T.B. Brunner, G.G. Grabenbauer, and P. Klein Phase I trial of strictly time-scheduled gemcitabine and cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer Int. J. Radiat. Oncol. Biol. Phys. 55 2003 144 153
17. J.J. Zarba, A.V. Jaremtchuk, and P. Gonzalez Jazey A phase I-II study of weekly cisplatin and gemcitabine with concurrent radiotherapy in locally advanced cervical carcinoma Ann. Oncol. 14 2003 1285 1290
18. J.A. Green, J.M. Kirwan, and J.F. Tierney Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis Lancet 358 2001 781 786
19. C.H. Choi, Y.Y. Lee, and M.K. Kim A matched-case comparison to explore the role of consolidation chemotherapy after concurrent chemoradiation in cervical cancer Int. J. Radiat. Oncol. Biol. Phys. 81 2011 1252 1257
20. P.A. DiSilvestro, S. Ali, and P.S. Craighead Phase III randomized trial of weekly cisplatin and irradiation versus cisplatin and tirapazamine and irradiation in stages IB2, IIA, IIB, IIIB, and IVA cervical carcinoma limited to the pelvis: a Gynecologic Oncology Group study J. Clin. Oncol. 32 2014 458 464
21. E.M. Swisher, R.E. Swensen, and B. Greer Weekly gemcitabine and cisplatin in combination with pelvic radiation in the primary therapy of cervical cancer: a phase I trial of the Puget Sound Oncology Consortium Gynecol. Oncol. 101 2006 429 435
22. P.G. Rose, K. Degeest, S. McMeekin, and N. Fusco A phase I study of gemcitabine followed by cisplatin concurrent with whole pelvic radiation therapy in locally advanced cervical cancer: a Gynecologic Oncology Group study Gynecol. Oncol. 107 2007 274 279