Endocannabinoid and ceramide levels are altered in patients with colorectal cancer

Oncology Reports

Volumn 34, Issue 1, 2015, Pages 447-454

  Chen, Ling ^a   Chen, Huixia ^a   Li, Yanting ^a   Li, Lei ^a   Qiu, Yan ^a   Ren, Jie ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

Anandamide; Ceramides; Colorectal cancer; Endocannabinoids

Indexed keywords

ACYLGLYCEROL LIPASE; ANANDAMIDE; ARACHIDONIC ACID; BIOLOGICAL MARKER; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CERAMIDE; CERAMIDE 16; CERAMIDE 18; CERAMIDE 20; CERAMIDE 24; CERAMIDE SYNTHASE 1; CERAMIDE SYNTHASE 2; CERAMIDE SYNTHASE 5; CERAMIDE SYNTHASE 6; DIACYLGLYCEROL LIPASE ALPHA; ENDOCANNABINOID; ENZYME; FATTY ACID AMIDASE; LIPOPROTEIN LIPASE; MONOUNSATURATED FATTY ACID; N ACYL PHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; SPHINGOSINE ACYLTRANSFERASE; UNCLASSIFIED DRUG; AMIDASE; FATTY-ACID AMIDE HYDROLASE; PHOSPHOLIPASE D;

ADULT; AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LIPID ANALYSIS; LIQUID CHROMATOGRAPHY; LYMPH NODE METASTASIS; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; TISSUE LEVEL; TUMOR INVASION; UPREGULATION; BIOSYNTHESIS; COLORECTAL TUMOR; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AMIDOHYDROLASES; CERAMIDES; COLORECTAL NEOPLASMS; ENDOCANNABINOIDS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; PHOSPHOLIPASE D; RECEPTOR, CANNABINOID, CB1; SPHINGOSINE N-ACYLTRANSFERASE;

EID: 84930024221     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3973     Document Type: Article

References (41)

1. Veldkamp R, Gholghesaei M, Bonjer HJ, Meijer DW, Buunen M, Jeekel J, Anderberg B, Cuesta MA, Cuschierl A, Fingerhut A, et al: European Association of Endoscopic Surgery (EAES): Laparoscopic resection of colon Cancer: Consensus of the European Association of Endoscopic Surgery (EAES). Surg Endosc 18: 1163-1185, 2004.
2. Tsujimoto H, Tsukioka S, Ono S, Sakamoto E, Sakamoto K, Tsuta K, Nakagawa F, Saito H, Uchida J, Kiniwa M, et al: Effect of leucovorin on the antitumor efficacy of the 5-FU prodrug, tegafur-uracil, in human colorectal cancer xenografts with various expression levels of thymidylate synthase. Oncol Lett 1: 973-980, 2010.
3. Yang SY, Miah A, Sales KM, Fuller B, Seifalian AM and Winslet M: Inhibition of the p38 MAPK pathway sensitises human colon cancer cells to 5-fluorouracil treatment. Int J Oncol 38: 1695-1702, 2011.
4. Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR, et al: Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50: 83-90, 1995.
5. Devane WA, Breuer A, Sheskin T, Järbe TU, Eisen MS and Mechoulam R: A novel probe for the cannabinoid receptor. J Med Chem 35: 2065-2069, 1992.
6. Di Carlo G and Izzo AA: Cannabinoids for gastrointestinal diseases: Potential therapeutic applications. Expert Opin Investig Drugs 12: 39-49, 2003.
7. De Petrocellis L, Cascio MG and Di Marzo V: The endocannabinoid system: A general view and latest additions. Br J Pharmacol 141: 765-774, 2004.
8. Piomelli D: The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4: 873-884, 2003.
9. Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA and Gilula NB: Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384: 83-87, 1996.
10. Pertwee RG (ed): Cannabinoid Receptors. Academic Press, New York, NY, 1995.
11. Pertwee RG: Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 74: 129-180, 1997.
12. Di Marzo V, Melck D, De Petrocellis L and Bisogno T: Cannabimimetic fatty acid derivatives in cancer and inflammation. Prostaglandins Other Lipid Mediat 61: 43-61, 2000.
13. Gonsiorek W, Lunn C, Fan X, Narula S, Lundell D and Hipkin RW: Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: Antagonism by anandamide. Mol Pharmacol 57: 1045-1050, 2000.
14. Guzmán M: Cannabinoids: Potential anticancer agents. Nat Rev Cancer 3: 745-755, 2003.
15. Ligresti A, Bisogno T, Matias I, De Petrocellis L, Cascio MG, Cosenza V, D'argenio G, Scaglione G, Bifulco M, Sorrentini I, et al: Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 125: 677-687, 2003.
16. Sarnataro D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C and Bifulco M: Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett 579: 6343-6349, 2005.
17. De Petrocellis L, Melck D, Palmisano A, Bisogno T, Laezza C, Bifulco M and Di Marzo V: The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci USA 95: 8375-8380, 1998.
18. Contassot E, Wilmotte R, Tenan M, Belkouch MC, Schnüriger V, de Tribolet N, Burkhardt K and Dietrich PY: Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. J Neuropathol Exp Neurol 63: 956-963, 2004.
19. Galve-Roperh I, Sánchez C, Cortés ML, Gómez del Pulgar T, Izquierdo M and Guzmán M: Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 6: 313-319, 2000.
20. Morad SA and Cabot MC: Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer 13: 51-65, 2013.
21. Grösch S, Schiffmann S and Geisslinger G: Chain length-specific properties of ceramides. Prog Lipid Res 51: 50-62, 2012.
22. Selzner M, Bielawska A, Morse MA, Rüdiger HA, Sindram D, Hannun YA and Clavien PA: Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 61: 1233-1240, 2001.
23. Garzotto M, White-Jones M, Jiang Y, Ehleiter D, Liao WC, Haimovitz-Friedman A, Fuks Z and Kolesnick R: 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer Res 58: 2260-2264, 1998.
24. Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J and Weichselbaum RR: Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res 57: 1270-1275, 1997.
25. Verheij M, van Blitterswijk WJ and Bartelink H: Radiation-induced apoptosis - the ceramide-SAPK signaling pathway and clinical aspects. Acta Oncol 37: 575-581, 1998.
26. Chen L, Xie B, Li L, Jiang W, Zhang Y, Fu J, Guan G and Qiu Y: Rapid and sensitive LC-MS/MS analysis of fatty acids in clinical amples. Chromatographia 77: 1241-1247, 2014.
27. Wu X, Han L, Zhang X, Li L, Jiang C, Qiu Y, Huang R, Xie B, Lin Z, Ren J, et al: Alteration of endocannabinoid system in human gliomas. J Neurochem 120: 842-849, 2012.
28. D'Argenio G, Valenti M, Scaglione G, Cosenza V, Sorrentini I and Di Marzo V: Upregulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. FASEB J 20: 568-570, 2006.
29. Izzo AA, Aviello G, Petrosino S, Orlando P, Marsicano G, Lutz B, Borrelli F, Capasso R, Nigam S, Capasso F, et al: Endocannabinoid Research Group: Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. J Mol Med Berl 86: 89-98, 2008.
30. Melck D, De Petrocellis L, Orlando P, Bisogno T, Laezza C, Bifulco M and Di Marzo V: Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 141: 118-126, 2000.
31. Cianchi F, Papucci L, Schiavone N, Lulli M, Magnelli L, Vinci MC, Messerini L, Manera C, Ronconi E, Romagnani P, et al: Cannabinoid receptor activation induces apoptosis through tumor necrosis factor α-mediated ceramide de novo synthesis in colon cancer cells. Clin Cancer Res 14: 7691-7700, 2008.
32. 9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. Mol Pharmacol 54: 834-843, 1998.
33. Ogretmen B and Hannun YA: Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 4: 604-616, 2004.
34. Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, et al: Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 279: 44311-44319, 2004.
35. Seumois G, Fillet M, Gillet L, Faccinetto C, Desmet C, François C, Dewals B, Oury C, Vanderplasschen A, Lekeux P, et al: De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. J Leukoc Biol 81: 1477-1486, 2007.
36. White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L and Voelkel-Johnson C: Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Oncogene 28: 1132-1141, 2009.
37. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA and Brenner DA: Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem 280: 27879-27887, 2005.
38. Senkal CE, Ponnusamy S, Bielawski J, Hannun YA and Ogretmen B: Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 24: 296-308, 2010.
39. Cairns RA, Harris IS and Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer 11: 85-95, 2011.
40. Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniëls VW, Machiels J, et al: De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res 70: 8117-8126, 2010.
41. Nashed M, Chisholm JW and Igal RA: Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells. Exp Biol Med 237: 1007-1017, 2012.