Anaerobic detoxification of acetic acid in a thermophilic ethanologen

Biotechnology for Biofuels

Volumn 8, Issue 1, 2015, Pages

  Shaw, A Joe ^a,b   Miller, Bethany B ^a   Rogers, Stephen R ^a   Kenealy, William R ^a,c   Meola, Alex ^a   Bhandiwad, Ashwini ^d,e   Sillers, W Ryan ^a,f   Shikhare, Indraneel ^a   Hogsett, David A ^a,g   Herring, Christopher D ^a,d  

^a Mascoma Corporation   (United States)

^b Novogy Inc   (United States)

^c Verdezyne Inc   (United States)

^d DARTMOUTH COLLEGE   (United States)

^e Energy Biosciences Institute   (United States)

^f Myriant Corporation   (United States)

^g OPX Biotechnologies Inc   (United States)

Author keywords

Acetate detoxification; Cellulosic ethanol; Inhibitors; Metabolic engineering

Indexed keywords

ACETIC ACID; ACETONE; CELLULOSIC ETHANOL; CORROSION INHIBITORS; DETOXIFICATION; ENZYMES; ETHANOL; GENES; METABOLIC ENGINEERING; METABOLISM; PH; VOLATILE FATTY ACIDS;

ACETIC ACID PRODUCTIONS; CELLULOSIC BIOMASS; CENTRAL METABOLISMS; ETHANOL PRODUCTIVITY; LOW-COST SOLUTION; METABOLIC PATHWAYS; PHOSPHOTRANSACETYLASE; THERMOANAEROBACTERIUM;

ORGANIC SOLVENTS;

ACETATE; ACETIC ACID; ANOXIC CONDITIONS; CELLULOSE; DETOXIFICATION; ETHANOL; INHIBITOR; THERMOPHILIC BACTERIUM;

THERMOANAEROBACTERIUM SACCHAROLYTICUM;

EID: 84930008019     PISSN: 17546834     EISSN: None     Source Type: Journal    
DOI: 10.1186/s13068-015-0257-4     Document Type: Article

References (37)

1. Perlack RD, Wright LL, Turhollow AF, Graham RL, Stoke BJ, Erbach DC. Biomass as feedstock for a bioenergy and bioproducts industry: the technical feasibility of a billion-ton annual supply. Technical Report. 2005; ORNL/TM-205/66. http://www.osti.gov/scitech/biblio/885984.
2. Palmqvist E, Hahn-Hägerdal B. Fermentation of lignocellulosic hydrolysates. II: inhibitors and mechanisms of inhibition. Bioresource Technol. 2000;74:25-33.
3. Ingram LO, Aldrich HC, Borges AC, Causey TB, Martinez A, Morales F, et al. Enteric bacterial catalysts for fuel ethanol production. Biotechnol Progr. 2009;15:855-66.
4. Weil JR, Dien B, Bothast R, Hendrickson R, Mosier NS, Ladisch MR. Removal of fermentation inhibitors formed during pretreatment of biomass by polymeric adsorbents. Ind Eng Chem Res. 2002;41:6132-8.
5. Larsson S, Palmqvist E, Hahn-Hägerdal B, Tengborg C, Stenberg K, Zacchi G, et al. The generation of fermentation inhibitors during dilute acid hydrolysis of softwood. Enzyme Microb Tech. 1999;24:151-9.
6. Ranatunga T, Jervis J, Helm R, McMillan J, Hatzis C. Identification of inhibitory components toxic toward Zymomonas mobilis CP4(pZB5) xylose fermentation. Appl Biochem Biotech. 1997;67:185-98.
7. Sreenath HK, Jeffries TW. Production of ethanol from wood hydrolyzate by yeasts. Bioresource Technol. 2000;72:253-60.
8. Taherzadeh MJ, Niklasson C, Lidén G. Acetic acid - friend or foe in anaerobic batch conversion of glucose to ethanol by Saccharomyces cerevisiae? Chem Eng Sci. 1997;52:2653-9.
9. Lawford H, Rousseau J. Improving fermentation performance of recombinant Zymomonas in acetic acid-containing media. Appl Biochem Biotechnol. 1998;70-72:161-72.
10. Booth IR. Regulation of cytoplasmic pH in bacteria. Microbiol Rev. 1985;49:359-78.
11. Mussatto SI, Roberto IC. Alternatives for detoxification of diluted-acid lignocellulosic hydrolyzates for use in fermentative processes: a review. Bioresource Technol. 2004;93:1-10.
12. Schneider H. Selective removal of acetic acid from hardwood-spent sulfite liquor using a mutant yeast. Enzyme Microb Tech. 1996;19:94-8.
13. Lakshmanaswamy A, Rajaraman E, Eiteman MA, Altman E. Microbial removal of acetate selectively from sugar mixtures. J Ind Microbiol Biot. 2011;38:1477-84.
14. Jones DT, Woods DR. Acetone-butanol fermentation revisited. Microbiol Rev. 1986;50:484-524.
15. Lütke-Eversloh T, Bahl H. Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production. Curr Opin Biotech. 2011;22:634-47.
16. Shaw AJ, Covalla SF, Hogsett DA, Herring CD. Marker removal system for Thermoanaerobacterium saccharolyticum and development of a markerless ethanologen. Appl Environ Microbiol. 2011;77:2534-6.
17. Shaw AJ, Podkaminer KK, Desai SG, Bardsley JS, Rogers SR, Thorne PG, et al. Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield. Proc Natl Acad Sci U S A. 2008;105:13769-74.
18. Shaw AJ, Hogsett DA, Lynd LR. Identification of the [FeFe]-hydrogenase responsible for hydrogen generation in Thermoanaerobacterium saccharolyticum and demonstration of increased ethanol yield via hydrogenase knockout. J Bacteriol. 2009;191:6457-64.
19. Wolfe AJ. The acetate switch. Microbiol Mol Biol Rev. 2005;69:12-50.
20. Kumari S, Tishel R, Eisenbach M, Wolfe AJ. Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coli. J Bacteriol. 1995;177:2878-86.
21. Fournier GP, Gogarten JP. Evolution of acetoclastic methanogenesis in Methanosarcina via horizontal gene transfer from cellulolytic clostridia. J Bacteriol. 2008;190:1124-7.
22. Ingram-Smith C, Martin SR, Smith KS. Acetate kinase: not just a bacterial enzyme. Trends Microbiol. 2006;14:249-53.
23. Weimer PJ. Control of product formation during glucose fermentation by Bacillus macerans. J Gen Microbiol. 1984;130:103-11.
24. Freier-Schröder D, Wiegel J, Gottschalk G. Butanol formation by Clostridium thermosaccharolyticum at neutral pH. Biotechnol Lett. 1989;11:831-6.
25. Desai SG, Guerinot ML, Lynd LR. Cloning of L-lactate dehydrogenase and elimination of lactic acid production via gene knockout in Thermoanaerobacterium saccharolyticum JW/SL-YS485. Appl Microbiol Biotechnol. 2004;65:600-5.
26. 2-rich termite gut. Microb Ecol. 2012;63:282-94.
27. Posewitz MC, Mulder DW, Peters JW. New frontiers in hydrogenase structure and biosynthesis. Curr Chem Biol. 2008;2:178-99.
28. Calusinska M, Happe T, Joris B, Wilmotte A. The surprising diversity of clostridial hydrogenases: a comparative genomic perspective. Microbiol. 2010;156:1575-88.
29. Björkqvist S, Ansell R, Adler L, Lidén G. Physiological response to anaerobicity of glycerol-3-phosphate dehydrogenase mutants of Saccharomyces cerevisiae. Appl Environ Microbiol. 1997;63:128-32.
30. Van Dijken JP, Scheffers WA. Redox balances in the metabolism of sugars by yeasts. FEMS Microbiol Lett. 1986;32:199-224.
31. Ansell R, Granath K, Hohmann S, Thevelein JM, Adler L. The two isoenzymes for yeast NAD + -dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. EMBO J. 1997;16:2179-87.
32. Brown SD, Guss AM, Karpinets TV, Parks JM, Smolin N, Yang S, et al. Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum. Proc Natl Acad Sci U S A. 2011;108:13752-7.
33. Mariano AP, Dias MOS, Junqueira TL, Cunha MP, Bonomi A, Filho RM. Butanol production in a first-generation Brazilian sugarcane biorefinery: technical aspects and economics of greenfield projects. Bioresource Technol. 2013;135:316-23.
34. Acetone uses and market data. Technical Report. Independent Commodity Information Services; ICIS News. 2007 09:34, updated 2010.
35. Aden A, Ruth M, Ibsen K, Jechura J, Neeves K, Sheehan J, et al. Lignocellulosic biomass to ethanol process design and economics utilizing co-current dilute acid prehydrolysis and enzymatic hydrolysis for corn stover. Technical Report. 2002; NREL/TP-510-32438, NREL, Golden, CO. http://www.osti.gov/scitech/biblio/15001119.
36. Shanks RMQ, Kadouri DE, MacEachran DP, O'Toole GA. New yeast recombineering tools for bacteria. Plasmid. 2009;62:88-97.
37. Shaw AJ, Hogsett DA, Lynd LR. Natural competence in Thermoanaerobacter and Thermoanaerobacterium species. Appl Environ Microbiol. 2010;76:4713-9.