Neoadjuvant therapy followed by local excision and two-stage total mesorectal excision: A new strategy for sphincter preservation in locally advanced ultra-low rectal cancer

Gastroenterology Report

Volumn 2, Issue 1, 2014, Pages 37-43

  Wang, Ting ^a   Wang, Jianping ^a   Deng, Yanhong ^a   Wu, Xiaojian ^a   Wang, Lei ^a  

^a THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Local excision; Neoadjuvant therapy; Rectal cancer; Sphincter preservation; Total mesorectal excision

Indexed keywords

EID: 84929996413     PISSN: None     EISSN: 20520034     Source Type: Journal    
DOI: 10.1093/gastro/got040     Document Type: Article

References (37)

1. van Gijn W, Marijnen CA, Nagtegaal ID et al. Dutch Colorectal Cancer Group. Pre-operative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol 2011;12:575-82.
2. Valentini V, Aristei C, Glimelius B et al. Scientific Committee. Multidisciplinary rectal cancer management: 2nd European rectal cancer consensus conference (EURECAcc2). Radiother Oncol 2009; 92:148-63.
3. Williams NS, Dixon MF and Johnston D. Reappraisal of the 5 centimetre rule of distal excision for carcinoma of the rectum: a study of distal intramural spread and of patients' survival. Br J Surg 1983; 70:150-54.
4. Pollett WG and Nicholls RJ. The relationship between the extent of distal clearance and survival and local recurrence rates after curative anterior resection for carcinoma of the rectum. Ann Surg 1983; 198:159-63.
5. Rullier E, Laurent C, Bretagnol F et al. Sphincter-saving resection for all rectal carcinomas: the end of the 2 cm distal rule. Ann Surg 2005;241:465-69.
6. Tilney HS and Tekkis PP. Extending the horizons of restorative rectal surgery: intersphincteric resection for low rectal cancer. Colorectal Dis 2008;10:3-16.
7. Martin ST, Heneghan HM and Winter DC. Systematic review of outcomes after intersphincteric resection for low rectal cancer. Br J Surg 2012;99:603-12.
8. Xu AG, Yu ZJ, Jiang B et al. Colorectal cancer in Guangdong Province of China: a demographic and anatomic survey. World J Gastroenterol 2010;16:960-65.
9. American Joint Committee on Cancer: AJCC Cancer Staging Handbook. 7th edn. New York, NY: Springer, 2010.
10. Sauer R, Becker H, Hohenberger W et al. Pre-operative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351:1731-40.
11. Jorge JM and Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum 1993;36:77-97.
12. Maas M, Nelemans PJ, Valentini V et al. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 2010;11:835-844.
13. Ministry of Health of the People's Republic of China. Chinese Standard for the Diagnosis and Treatment of Colorectal Cancer. Chin J Gastroint Surg 2010;13:865-75.
14. Schell SR, Zlotecki RA, Mendenhall WM et al. Transanal excision of locally advanced rectal cancers down-staged using neoadjuvant chemoradiotherapy. J Am Coll Surg 2002;194: 584-91.
15. Ruo L, Guillem JG, Minsky BD et al. Pre-operative radiation with or without chemotherapy and full-thickness transanal excision for selected T2 and T3 distal rectal cancers. Int J Colorectal Dis 2002;17: 54-58.
16. Bonnen M, Crane C, Vauthey JN et al. Long-term results using local excision after pre-operative chemoradiation among selected T3 rectal cancer patients. Int J Radiat Oncol Biol Phys 2004;60: 1098-105.
17. Stipa F, Zernecke A, Moore HG et al. Residual mesorectal lymph node involvement following neoadjuvant combined-modality therapy: rationale for radical resection? Ann Surg Oncol 2004;11: 187-91.
18. Caricato M, Borzomati D, Ausania F et al. Complementary use of local excision and transanal endoscopic microsurgery for rectal cancer after neoadjuvant chemoradiation. Surg Endosc 2006;20: 1203-7.
19. Borschitz T, Wachtlin D, Mohler M et al. Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer. Ann Surg Oncol 2008; 15:712-20.
20. Nair RM, Siegel EM, Chen DT et al. Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectum. J Gastrointest Surg 2008;12: 1797-806.
21. Huh JW, Jung EJ, Park YA et al. Pre-operative chemoradiation followed by transanal excision for rectal cancer. J Surg Res 2008;148: 244-50.
22. Kundel Y, Brenner R, Purim O et al. Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? Dis Colon Rectum 2010; 53:1624-31.
23. Callender GG, Das P, Rodriguez-Bigas MA et al. Local excision after pre-operative chemoradiation results in an equivalent outcome to total mesorectal excision in selected patients with T3 rectal cancer. Ann Surg Oncol 2010;17:441-47.
24. Belluco C, De Paoli A, Canzonieri V et al. Long-term outcome of patients with complete pathological response after neoadjuvant chemoradiation for cT3 rectal cancer: implications for local excision surgical strategies. Ann Surg Oncol 2011;18:3686-93.
25. Lezoche G, Guerrieri M, Baldarelli M et al. Transanal endoscopic microsurgery for 135 patients with small non-advanced low rectal cancer (iT1-iT2, iN0): short-and long-term results. Surg Endosc 2011;25:1222-29.
26. Issa N, Murninkas A, Powsner E et al. Long-term outcome of local excision after complete pathological response to neoadjuvant chemoradiation therapy for rectal cancer. World J Surg 2012;36: 2481-87.
27. Tennyson N, Mendenhall WM, Morris CG et al. Transanal excision with radiation therapy for rectal adenocarcinoma. Clin Med Res 2012;10:224-29.
28. Yu CS, Yun HR, Shin EJ et al. Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis. Am J Surg 2013;206:482-87.
29. Dademade G and Wexner SD. Complete response after neoadjuvant therapy in rectal cancer: to operate or not to operate? Dig Dis 2012;30 (suppl 2), 109-17.
30. Fichera A and Allaix ME. Paradigm-shifting new evidence for treatment of rectal cancer. J Gastrointest Surg 2013, July 26.
31. Canda AE, Terzi C, Gorken IB et al. Effects of pre-operative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patients. Int J Colorectal Dis 2010;25:197-204.
32. Habr-Gama A, Perez RO, Nadalin W et al. Operative versus non-operative treatment for stage 0 distal rectal cancer following chemoradiation therapy. Long-term results. Ann Surg 2004;240: 711-17.
33. Maas M, Beets-Tan RG, Lambregts DM et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol 2011;29:4633-40.
34. Smith JD, Ruby JA, Goodman KA et al. Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy. Ann Surg 2012;256:965-72.
35. Hiotis SP, Weber SM, Cohen AM et al. Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients. J Am Coll Surg 2002; 194:131-35.
36. Guillem JG, Chessin DB, Shia J et al. Clinical examination following pre-operative chemoradiation for rectal cancer is not a reliable surrogate end point. J Clin Oncol 2005;23:3475-79.
37. Duldulao MP, Lee W, Streja L et al. Distribution of residual cancer cells in the bowel wall after neoadjuvant chemoradiation in patients with rectal cancer. Dis Colon Rectum 2013;56:142-49.