Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB-415 breast cancer cell lines

Oncology Letters

Volumn 10, Issue 1, 2015, Pages 156-162

  Todd, Maria C ^a   Petty, Heather M ^a   King, Jonathan M ^b   Piana Marshall, Brytanie N ^a   Sheller, Rebecca A ^a   Cuevas, Maria E ^a  

^a SOUTHWESTERN UNIVERSITY   (United States)

^b TRINITY UNIVERSITY   (United States)

Author keywords

Cell motility; Metastasis; Tight junctions

Indexed keywords

CLAUDIN 1; CLAUDIN 3; CLAUDIN 4; SMALL INTERFERING RNA;

ARTICLE; BREAST CANCER; BREAST METASTASIS; CANCER GROWTH; CELL FRACTIONATION; CELL MOTILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; PROTEIN EXPRESSION; TRANSIENT TRANSFECTION; TUMOR GROWTH; WESTERN BLOTTING;

EID: 84929875923     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3160     Document Type: Article

References (14)

1. American Cancer Society: Breast Cancer Facts & Figures. http://www.cancer.org/research/cancerfactsstatistics/breast-cancer-facts-figures. Accessed February 24, 2014.
2. Turksen K and Troy TC: Barriers built on claudins. J Cell Sci 117: 2435-2447, 2004.
3. Kominsky SL, Vali M, Korz D, Gabig TG, Weitzman SA, Argani P and Sukumar S: Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Am J Pathol 164: 1627-1633, 2004.
4. Lanigan F, McKiernan E, Brennan DJ, Hegarty S, Millikan RC, McBryan J, et al: Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int J Cancer 124: 2088-2097, 2009.
5. Tokés AM, Kulka J, Paku S, Szik A, Páska C, Novák PK, Szilák L, Kiss A, Bögi K and Schaff Z: Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res 7: R296-R305, 2005.
6. Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP and Sukumar S: Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal and carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22: 2021-2033, 2003.
7. Tokés AM, Kulka J, Paku S, Máthé M, Páska C, Lódi C, Kiss A and Schaff Z: The expression of five different claudins in invasive breast carcinomas: comparison of pT1pN1 and pT1pN0 tumors. Pathol Res Pract 201: 537-544, 2005.
8. Agarwal R, D'Souza T and Morin PJ: Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res 65: 7378-7385, 2005.
9. Oku N, Sasabe E, Ueta E, Yamamoto T and Osaki T: Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1. Cancer Res 66: 5251-5257, 2006.
10. Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK and Beauchamp RD: Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest 115: 1765-1776, 2005.
11. Pan XY, Wang B, Che YC, Weng ZP, Dai HY and Peng W: Expression of claudin-3 and claudin-4 in normal, hyperplastic, and malignant endometrial tissue. Int J Gynecol Cancer 17: 233-241, 2007.
12. Konecny GE, Agarwal R, Keeney GA, Winterhoff B, Jones MB, Mariani A, et al: Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometroid endometrial cancer. Gynecol Oncol 109: 263-269, 2008.
13. French AD, Fiori JL, Camilli TC, Leotlela PD, O'Connell MP, Frank BP, Subaran S, Indig FE, Taub DD and Weeraratna AT: PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. Int J Med Sci 6: 93-101, 2009.
14. Michl P, Barth C, Buchholz M, Lerch MM, Rolke M, Holzmann KH, et al: Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res 63: 6265-6271, 2003