A variant within the AQP1 3ʹ-untranslated region is associated with running performance, but not weight changes, during an Ironman Triathlon

Journal of Sports Sciences

Volumn 33, Issue 13, 2015, Pages 1342-1348

  Saunders, Colleen J ^a   Posthumus, Michael ^a   O’Connell, Kevin ^a   September, Alison V ^a   Collins, Malcolm ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

aquaporin 1; athletic performance; body fluids; water channel proteins

Indexed keywords

3' UNTRANSLATED REGION; AQP1 PROTEIN, HUMAN; AQUAPORIN 1; SODIUM;

3' UNTRANSLATED REGION; ADULT; BLOOD; CYCLING; ENDURANCE; GENETICS; GENOTYPE; HUMAN; MALE; PHYSIOLOGY; RUNNING; SINGLE NUCLEOTIDE POLYMORPHISM; SWIMMING; WEIGHT REDUCTION;

3' UNTRANSLATED REGIONS; ADULT; AQUAPORIN 1; BICYCLING; GENOTYPE; HUMANS; MALE; PHYSICAL ENDURANCE; POLYMORPHISM, SINGLE NUCLEOTIDE; RUNNING; SODIUM; SWIMMING; WEIGHT LOSS;

EID: 84929834258     PISSN: 02640414     EISSN: 1466447X     Source Type: Journal    
DOI: 10.1080/02640414.2014.989535     Document Type: Article

References (25)

1. Armstrong, L. E., Johnson, E. C., Ganio, M. S., Judelson, D. A., Vingren, J. L., Kupchak, B. R., … Williamson, K. H. (2014). Effective body water and body mass changes during summer ultra-endurance road cycling. Journal of Sports Sciences. Advance online publication. doi:10.1080/02640414.2014.932918
2. Chanock, S. J., Manolio, T., Boehnke, M., Boerwinkle, E., Hunter, D. J., Thomas, G., … Collins, F. S. (2007). Replicating genotype-phenotype associations. Nature, 447, 655–660.
3. de Milander, L., Kun, M. A., September, A. V., Schwellnus, M. P., Noakes, T. D., & Collins, M. (2012). AVPR2 gene and weight changes during triathlons. International Journal of Sports Medicine, 33, 67–75.
4. Endeward, V., Musa-Aziz, R., Cooper, G. J., Chen, L. M., Pelletier, M. F., & Virkki, L. V., … Gros, G. (2006). Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane. TheFASEB Journal, 20, 1974–1981.
5. Eynon, N., Ruiz, J. R., Oliveira, J., Duarte, J. A., Birk, R., & Lucia, A. (2011). Genes and elite athletes: A roadmap for future research. The Journal of Physiology, 589, 3063–3070.
6. Fábrega, E., Berja, A., García-Unzueta, M. T., Guerra-Ruiz, A., Cobo, M., López, M., … Pons-Romero, F. (2011). Influence of aquaporin-1 gene polymorphism on water retention in liver cirrhosis. Scandinavian Journal of Gastroenterology, 46, 1267–1274.
7. Hew-Butler, T., Verbalis, J. G., & Noakes, T. D. (2006). Updated fluid recommendation: Position statement from the International Marathon Medical Directors Association (IMMDA). Clinical Journal of Sport Medicine, 16, 283–292.
8. Lahiri, K., & Nurnberger, J. I. (1991). A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Research, 19, 5444.
9. Martínez, J. L., Carrión, A., Florián, M. E., Martín, J. A., López-Taylor, J. R., Fahey, T. D., & Rivera, M. A. (2009). Aquaporin-1 gene DNA variation predicts performance in Hispanic marathon runners. Medicina Sportiva, 13, 251–255.
10. Mokone, G. G., Schwellnus, M. P., Noakes, T. D., & Collins, M. (2006). The COL5A1 gene and Achilles tendon pathology. Scandinavian Journal of Medicine and Science in Sports, 16, 19–26.
11. Moon, C., Preston, G. M., Griffin, C. A., Jabs, E. W., & Agre, P. (1993). The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization. Journal of Biological Chemistry, 268, 15772–15778.
12. Musumeci, G. (2013). The role of aquaporin 1 in knee osteoarthritis: A contemporary review. OA Arthritis, 1, 2.
13. Noakes, T. D., Sharwood, K., Speedy, D., Hew, T., Reid, S., Dugas, J., … Weschler, L. (2005). Three independent biological mechanisms cause exercise-associated hyponatremia: Evidence from 2,135 weighed competitive athletic performances. Proceedings of the National Academy of Sciences, 102, 18550–18555.
14. Perneger, T. V. (1998). What’s wrong with Bonferroni adjustments. BMJ, 316, 1236–1238.
15. Pérusse, L., Rankinen, T., Hagberg, J. M., Loos, R. J. F., Roth, S. M., Sarzynski, M. A., … Bouchard, C. (2013). Advances in exercise, fitness, and performance genomics in 2012. Medicine and Science in Sports and Exercise, 45, 824–831.
16. Rivera, M. A., Martínez, J. L., Carrion, A., & Fahey, T. D. (2011). AQP-1 association with body fluid loss in 10-km runners. International Journal of Sports Medicine, 32, 229–233.
17. Rüst, C. A., Knechtle, B., Knechtle, P., Wirth, A., & Rosemann, T. (2012). Body mass change and ultraendurance performance: A decrease in body mass is associated with an increased running speed in male 100-km ultramarathoners. Journal of Strength and Conditioning Research, 26, 1505–1516.
18. Saunders, C. J., De Milander, L., Hew-Butler, T., Xenophontos, S. L., Cariolou, M. A., Anastassiades, L. C., … Collins, M. (2006). Dipsogenic genes associated with weight changes during Ironman Triathlons. Human Molecular Genetics, 15, 2980–2987.
19. Sawka, M. N., Burke, L. M., Eichner, E. R., Maughan, R. J., Montain, S. J., & Stachenfeld, N. S. (2007). American College of Sports Medicine position stand. Exercise and fluid replacement. Medicine and Science in Sports and Exercise, 39, 377–390.
20. Sharwood, K., Collins, M., Goedecke, J., Wilson, G., & Noakes, T. (2002). Weight changes, sodium levels, and performance in the South African Ironman Triathlon. Clinical Journal of Sport Medicine, 12, 391–399.
21. Sharwood, K. A., Collins, M., Goedecke, J. H., Wilson, G., & Noakes, T. D. (2004). Weight changes, medical complications, and performance during an Ironman triathlon. British Journal of Sports Medicine, 38, 718–724.
22. Sui, H., Han, B.-G., Lee, J. K., Walian, P., & Jap, B. K. (2001). Structural basis of water-specific transport through the AQP1 water channel. Nature, 414, 872–878.
23. Tam, N., & Noakes, T. D. (2013). The quantification of body fluid allostasis during exercise. Sports Medicine, 43, 1289–1299.
24. Tucker, R., & Collins, M. (2012). What makes champions? A review of the relative contribution of genes and training to sporting success. British Journal of Sports Medicine, 46, 555–561.
25. Wakayama, Y. (2007). Skeletal muscle regeneration may be enhanced by overexpression of aquaporin 1 in intramuscular capillary endothelial cells. Medical Hypotheses, 68, 856–859.