Out of the orphanage and into the clinic - Therapeutic targeting of GATA3

New England Journal of Medicine

Volumn 372, Issue 21, 2015, Pages 2060-2061

  Bochner, Bruce S ^a   Schleimer, Robert P ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; BENRALIZUMAB; DUPILUMAB; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LEBRIKIZUMAB; MEPOLIZUMAB; OMALIZUMAB; RESLIZUMAB; SB 010; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG; DEOXYRIBOZYME; MESSENGER RNA;

ALLERGIC ASTHMA; ANTIBODY PRODUCTION; BRONCHOCONSTRICTION; CELL ACTIVATION; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; DRUG BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TARGETING; EDITORIAL; EOSINOPHIL; HUMAN; LYMPHOID CELL; MAST CELL; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; TH2 CELL; UNSPECIFIED SIDE EFFECT; ASTHMA; MALE; METABOLISM;

ANTI-ASTHMATIC AGENTS; ASTHMA; DNA, CATALYTIC; GATA3 TRANSCRIPTION FACTOR; HUMANS; MALE; RNA, MESSENGER;

EID: 84929783330     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1502660     Document Type: Editorial

References (10)

1. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
2. Lloyd CM, Hessel EM. Functions of T cells in asthma: more than just T(H)2 cells. Nat Rev Immunol 2010;10:838-48.
3. Craft JE. Follicular helper T cells in immunity and systemic autoimmunity. Nat Rev Rheumatol 2012;8:337-47.
4. Diamant Z, Gauvreau GM, Cockcroft DW, et al. Inhaled allergen bronchoprovocation tests. J Allergy Clin Immunol 2013;132(5):1045.e6-1055.e6.
5. Tindemans I, Serafini N, Di Santo JP, Hendriks RW. GATA-3 function in innate and adaptive immunity. Immunity 2014;41:191-206.
6. Fahy JV. Type 2 inflammation in asthma - present in most, absent in many. Nat Rev Immunol 2015;15:57-65.
7. Akdis CA. Therapies for allergic inflammation: refining strategies to induce tolerance. Nat Med 2012;18:736-49.
8. Krug N, Hohlfeld JM, Kirsten A-M, et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med 2015;372:1987-95.
9. Fahy JV, Fleming HE, Wong HH, et al. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med 1997;155:1828-34.
10. Gauvreau GM, O'Byrne PM, Boulet LP, et al. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med 2014;370:2102-10.