Clinical and autoantibody profile in systemic sclerosis: Baseline characteristics from a West Malaysian cohort

International Journal of Rheumatic Diseases

Volumn 18, Issue 4, 2015, Pages 459-465

  Sujau, Ibrahim ^a   Ng, Chin Teck ^a   Sthaneshwar, Pavai ^a   Sockalingam, Sargunan ^a   Cheah, Tien Eang ^a   Yahya, Fariz ^a   Jasmin, Raja ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Autoantibodies; Clinical profile; Malaysia; Systemic sclerosis

Indexed keywords

AUTOANTIBODY; CENTROMERE ANTIBODY; CHROMOSOME NOR 90 ANTIBODY; DNA DIRECTED RNA POLYMERASE III ANTIBODY; FIBRILLARIN ANTIBODY; KU ANTIBODY; PLATELET DERIVED GROWTH FACTOR RECEPTOR ANTIBODY; PM SCL 100 ANTIBODY; PM SCL 75 ANTIBODY; RO 52 ANTIBODY; SCL 70 ANTIBODY; TH TO ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CALCINOSIS; CHINESE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; FINGER ULCER; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY DISORDER; HUMAN; IMMUNOBLOTTING; LUNG DISEASE; LUNG FIBROSIS; LUNG FUNCTION TEST; MALAYSIAN; MALE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAYNAUD PHENOMENON; SENSITIVITY AND SPECIFICITY; SKIN DISEASE; SYSTEMIC SCLEROSIS; TELANGIECTASIA; VASCULITIC RASH; AGE; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; ETHNOLOGY; IMMUNOLOGY; MALAYSIA; MIDDLE AGED; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; RARE DISEASE; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX DIFFERENCE; STATISTICS AND NUMERICAL DATA; TEACHING HOSPITAL; UNIVERSITY HOSPITAL;

ACADEMIC MEDICAL CENTERS; ADULT; AGE FACTORS; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOANTIBODIES; CASE-CONTROL STUDIES; FEMALE; HOSPITALS, TEACHING; HUMANS; MALAYSIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RARE DISEASES; RISK ASSESSMENT; SCLERODERMA, SYSTEMIC; SEVERITY OF ILLNESS INDEX; SEX FACTORS; STATISTICS, NONPARAMETRIC;

EID: 84929705407     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/1756-185X.12322     Document Type: Article

References (36)

1. Balbir-Gurman A, Braun-Moscovici Y (2012) Scleroderma - new aspects in pathogenesis and treatment. Best Prac Res Clin Rheumatol 26, 13-24.
2. Steen VD, Medsger TA Jr (2000) Severe organ involvement in systemic sclerosis with diffuse scleroderma. Arthritis Rheum 43, 2437-44.
3. Elhai M, Meune C, Avouac J, Kahan A, Allanore Y (2012) Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies. Rheumatology 51, 1017-26.
4. Steen VD (2005) Autoantibodies in systemic sclerosis. Semin Arthritis Rheum 35, 35-42.
5. Graf SW, Hakendorf P, Lester S et al. (2012) South Australian scleroderma register: autoantibodies as predictive biomarkers of phenotype and outcome. Int J Rheum Dis 15, 102-9.
6. Mehra S, Walker J, Patterson K, Fritzler MJ (2013) Autoantibodies in systemic sclerosis. Autoimmune Rev 12, 340-54.
7. Kasturi KN, Hatakeyama A, Spiera H, Bona CA (1995) Antifibrillarin autoantibodies present in systemic sclerosis and other connective tissue diseases interact with similar epitopes. J Exp Med 181, 1027-36.
8. Parker JC, Burlingame RW, Bunn CC (2009) Prevalence of antibodies to Ro-52 in a serologically defined population of patients with systemic sclerosis. J Autoimmune Dis 6, 2.
9. Masi AT andSubcommittee For Scleroderma Criteria of the American Rheumatism Association, Diagnostic and Therapeutic Criteria Committee (1980) Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23, 581-90.
10. Pagalavan L, Ong SG (2007) Demography, clinical and laboratory features of systemic sclerosis in a Malaysian rheumatology centre. Med J Malaysia 62, 117-21.
11. Teh CL, Kuan YC, Wong JS (2009) Systemic sclerosis in Sarawak: a profile of patients treated in the Sarawak General Hospital. Rheumatol Int 29, 1243-5.
12. Panicheewa S, Chitrabamrung S, Verasertniyom O et al. (1991) Diffuse systemic sclerosis and related diseases in Thailand. Clin Rheumatol 10, 124-9.
13. Low AH, Wong S, Thumboo J et al. (2012) Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population. Rheumatology 51, 1465-70.
14. Low AHLTG, Law WG, Ng SC et al. (2013) Disease characteristics of the Singapore systemic sclerosis cohort. Proc Singapore Healthcare 22, 8-14.
15. Luo Y, Wang Y, Wang Q, Xiao R, Lu Q (2013) Systemic sclerosis: genetics and epigenetics. J Autoimmun 41, 161-7.
16. Gupta R, Thabah MM, Gupta S, Shankar S, Kumar A (2009) Clinical significance of antiphospholipid antibodies in Indian scleroderma patients. Rheumatol Int 30, 277-9.
17. Hashimoto A, Endo H, Kondo H, Hirohata S (2012) Clinical features of 405 Japanese patients with systemic sclerosis. Mod Rheumatol 22, 272-9.
18. Chen CHCY, Lan JL, Chen DY (2007) Scleroderma renal crisis: a rare complication of systemic sclerosis with poor prognosis - experience in a medical center in central Taiwan. J Rheumatol ROC 21, 59-64.
19. Wang J, Assassi S, Guo G et al. (2013) Clinical and serological features of systemic sclerosis in a Chinese cohort. Clin Rheumatol 32, 617-21.
20. Thoua NM, Bunce C, Brough G, Forbes A, Emmanuel AV, Denton CP (2010) Assessment of gastrointestinal symptoms in patients with systemic sclerosis in a UK tertiary referral centre. Rheumatology 49, 1770-5.
21. Hunzelmann N, Genth E, Krieg T et al. (2008) The registry of the German network for systemic scleroderma: frequency of disease subsets and patterns of organ involvement. Rheumatology 47, 1185-92.
22. Mierau R, Moinzadeh P, Riemekasten G et al. (2011) Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features. Arthritis Res Ther 13, R172.
23. Steen VD, Powell DL, Medsger TA Jr (1988) Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis Rheum 31, 196-203.
24. Low AH, Johnson SR, Lee P (2009) Ethnic influence on disease manifestations and autoantibodies in Chinese-descent patients with systemic sclerosis. J Rheumatol 36, 787-93.
25. Hudson M, Pope J, Mahler M et al. (2012) Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis. Arthritis Res Ther 14, R50.
26. Dick T, Mierau R, Sternfeld R, Weiner EM, Genth E (1995) Clinical relevance and HLA association of autoantibodies against the nucleolus organizer region (NOR-90). J Rheumatol 22, 67-72.
27. Hanke K, Bruckner CS, Dahnrich C et al. (2009) Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients. Arthritis Res Ther 11, R22.
28. Mitri GM, Lucas M, Fertig N, Steen VD, Medsger TA Jr (2003) A comparison between anti-Th/To- and anticentromere antibody-positive systemic sclerosis patients with limited cutaneous involvement. Arthritis Rheum 48, 203-9.
29. Okano Y, Medsger TA Jr (1990) Autoantibody to Th ribonucleoprotein (nucleolar 7-2 RNA protein particle) in patients with systemic sclerosis. Arthritis Rheum 33, 1822-8.
30. Baroni SS, Santillo M, Bevilacqua F et al. (2006) Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Eng J Med 354, 2667-76.
31. Harvey GR, Butts S, Rands AL, Patel Y, McHugh NJ (1999) Clinical and serological associations with anti-RNA polymerase antibodies in systemic sclerosis. Clin Exp Immunol 117, 395-402.
32. Santiago M, Baron M, Hudson M, Burlingame RW, Fritzler MJ (2007) Antibodies to RNA polymerase III in systemic sclerosis detected by ELISA. J Rheumatol 34, 1528-34.
33. Hesselstrand R, Scheja A, Shen GQ, Wiik A, Akesson A (2003) The association of antinuclear antibodies with organ involvement and survival in systemic sclerosis. Rheumatology 42, 534-40.
34. Nikpour M, Hissaria P, Byron J et al. (2011) Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort. Arthritis Res Ther 13, R211.
35. Satoh T, Ishikawa O, Ihn H et al. (2009) Clinical usefulness of anti-RNA polymerase III antibody measurement by enzyme-linked immunosorbent assay. Rheumatology 48, 1570-4.
36. Rozman B, Cucnik S, Sodin-Semrl S et al. (2008) Prevalence and clinical associations of anti-Ku antibodies in patients with systemic sclerosis: a European EUSTAR-initiated multi-centre case-control study. Ann Rheum Dis 67, 1282-6.