Effect of a preoperative decontamination protocol on surgical site infections in patients undergoing elective orthopedic surgery with hardware implantation

JAMA Surgery

Volumn 150, Issue 5, 2015, Pages 390-395

  Bebko, Serge P ^a,b   Green, David M ^b   Awad, Samir S ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE; POVIDONE IODINE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CHRONIC KIDNEY DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL PROTOCOL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DECONTAMINATION PROTOCOL; ELECTIVE ORTHOPEDIC SURGERY; ELECTIVE SURGERY; FEMALE; HARDWARE IMPLANTATION; HOSPITALIZATION; HUMAN; HYPERTENSION; IMPLANTATION; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; ORTHOPEDIC SURGERY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SMOKING; STAPHYLOCOCCUS EPIDERMIDIS; SURGICAL INFECTION; TOBACCO USE; VANCOMYCIN RESISTANT ENTEROCOCCUS; VIDEORECORDING; ADVERSE EFFECTS; CLINICAL TRIAL; FOLLOW UP; MORBIDITY; PREOPERATIVE CARE; PROCEDURES; PROSTHESES AND ORTHOSES; STANDARDS; SURGICAL WOUND INFECTION; TRENDS; UNITED STATES; WASTE MANAGEMENT;

CLINICAL PROTOCOLS; DECONTAMINATION; ELECTIVE SURGICAL PROCEDURES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MORBIDITY; ORTHOPEDIC PROCEDURES; PREOPERATIVE CARE; PROSPECTIVE STUDIES; PROSTHESES AND IMPLANTS; SURGICAL WOUND INFECTION; TEXAS;

EID: 84929677889     PISSN: 21686254     EISSN: 21686262     Source Type: Journal    
DOI: 10.1001/jamasurg.2014.3480     Document Type: Article

References (22)

1. Anderson DJ, Kaye KS. Staphylococcal surgical site infections. Infect Dis Clin North Am. 2009;23(1):53-72.
2. Greene LR. Guide to the elimination of orthopedic surgery surgical site infections: an executive summary of the Association for Professionals in Infection Control and Epidemiology elimination guide. Am J Infect Control. 2012;40(4):384-386.
3. Anderson DJ, Sexton DJ, Kanafani ZA, Auten G, Kaye KS. Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol. 2007;28(9):1047-1053.
4. Engemann JJ, Carmeli Y, Cosgrove SE, et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis. 2003;36(5):592-598.
5. Klevens RM, Edwards JR, Richards CL, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. http://www.cdc.gov/HAI/pdfs/hai/infections-deaths.pdf. Published March-April 2007. Accessed January 26, 2015.
6. Bosco JA III, Slover JD, Haas JP. Perioperative strategies for decreasing infection: a comprehensive evidence-based approach. J Bone Joint Surg Am. 2010;92(1):232-239.
7. Kallen AJ, Wilson CT, Larson RJ. Perioperative intranasal mupirocin for the prevention of surgical-site infections: systematic review of the literature and meta-analysis. Infect Control Hosp Epidemiol. 2005;26(12):916-922.
8. Kim DH, Spencer M, Davidson SM, et al. Institutional prescreening for detection and eradication of methicillin-resistant Staphylococcus aureus in patients undergoing elective orthopaedic surgery. J Bone Joint Surg Am. 2010;92(9):1820-1826.
9. Bode LG, Kluytmans JA, Wertheim HF, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 2010;362(1):9-17.
10. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR; Hospital Infection Control Practices Advisory Committee. Guideline for prevention of surgical site infection, 1999. Infect Control Hosp Epidemiol. 1999;20(4):250-278.
11. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992;13(10):606-608.
12. Cooper RA. Surgical site infections: epidemiology and microbiological aspects in trauma and orthopaedic surgery. Int Wound J. 2013;10(suppl 1):3-8.
13. Darouiche RO, Wall MJ Jr, Itani KM, et al. Chlorhexidine-alcohol vs povidone-iodine for surgical-site antisepsis. N Engl J Med. 2010;362(1):18-26.
14. Kalmeijer MD, Coertjens H, van Nieuwland-Bollen PM, et al. Surgical site infections in orthopedic surgery: the effect of mupirocin nasal ointment in a double-blind, randomized, placebo-controlled study. Clin Infect Dis. 2002;35(4):353-358.
15. Rao N, Cannella BA, Crossett LS, Yates AJ Jr, McGough RL III, Hamilton CW. Preoperative screening/decolonization for Staphylococcus aureus to prevent orthopedic surgical site infection: prospective cohort study with 2-year follow-up. J Arthroplasty. 2011;26(8):1501-1507.
16. Patel JB, Gorwitz RJ, Jernigan JA. Mupirocin resistance. Clin Infect Dis. 2009;49(6):935-941.
17. Simor AE, Phillips E, McGeer A, et al. Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis. 2007;44(2):178-185.
18. Phillips MS, Bosco J III, Rosenberg A, et al. Preventing Staphylococcus aureus surgical site infections: an open-label, randomized trial of nasal mupirocin ointment and nasal povidone-iodine solution. In: Proceedings from the IDSA/SHEA Conference; October 20, 2012; San Diego, CA.
19. Buehlmann M, Frei R, Fenner L, Dangel M, Fluckiger U, Widmer AF. Highly effective regimen for decolonization of methicillin-resistant Staphylococcus aureuscarriers. Infect Control Hosp Epidemiol. 2008;29(6):510-516.
20. Benito N, Franco M, Coll P, et al. Etiology of surgical site infections after primary total joint arthroplasties. J Orthop Res. 2014;32(5):633-637.
21. Awad SS, Palacio CH, Subramanian A, et al. Implementation of a methicillin-resistant Staphylococcus aureus (MRSA) prevention bundle results in decreased MRSA surgical site infections. Am J Surg. 2009;198(5):607-610.
22. Korol E, Johnston K, Waser N, et al. A systematic review of risk factors associated with surgical site infections among surgical patients. PLoS One. 2013;8(12):e83743.