Glutamine supplementation, citrulline production, and de novo arginine synthesis: Is there a relation?

American Journal of Clinical Nutrition

Volumn 101, Issue 4, 2015, Pages 890-892

  Ligthart Melis, Gerdien C ^a   Marini, Juan C ^b   Engelen, Marielle P K J ^a   Deutz, Nicolaas E P ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b CHILDREN S NUTRITION RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMMONIA; ARGININE; ASPARTIC ACID; CITRULLINE; GLUTAMINE; NITROGEN; STABLE ISOTOPE; DIPEPTIDE;

ABDOMINAL SURGERY; AMINO ACID SYNTHESIS; HUMAN; LETTER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEASUREMENT; METABOLISM; MOLECULE; PUBLICATION; SURGICAL PATIENT; TANDEM MASS SPECTROMETRY; VITAMIN SUPPLEMENTATION; BIOSYNTHESIS; DIET SUPPLEMENTATION; DRUG EFFECTS; FEMALE; KIDNEY; MALE;

ARGININE; DIETARY SUPPLEMENTS; DIPEPTIDES; FEMALE; GLUTAMINE; HUMANS; KIDNEY; MALE;

EID: 84929659442     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.104679     Document Type: Letter

References (10)

1. Buijs N, Brinkmann SJ, Oosterink JE, Luttikhold J, Schierbeek H, WisselinkW, Beishuizen A, van Goudoever JB, Houdijk AP, van Leeuwen PA, et al. Intravenous glutamine supplementation enhances renal de novo arginine synthesis in humans: a stable isotope study. Am J Clin Nutr 2014;100:1385-91.
2. Ligthart-Melis GC, van de Poll MC, Boelens PG, Dejong CH, Deutz NE, van Leeuwen PA. Glutamine is an important precursor for de novo synthesis of arginine in humans. Am J Clin Nutr 2008;87:1282-9.
3. Peters JH, Wierdsma NJ, Teerlink T, van Leeuwen PA, Mulder CJ, van Bodegraven AA. The citrulline generation test: proposal for a new enterocyte function test. Aliment Pharmacol Ther 2008;27:1300-10.
4. Houdijk AP, Rijnsburger ER, Jansen J,Wesdorp RI, Weiss JK, McCamish MA, Teerlink T, Meuwissen SG, Haarman HJ, Thijs LG, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998;352:772-6.
5. Castillo L, Sanchez M, Vogt J, Chapman TE, DeRojas-Walker TC, Tannenbaum SR, Ajami AM, Young VR. Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis. Am J Physiol 1995;268:E360-7.
6. Castillo L, Chapman TE, Sanchez M, Yu YM, Burke JF, Ajami AM, Vogt J, Young VR. Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc Natl Acad Sci USA 1993;90:7749-53.
7. Luiking YC, Poeze M, Ramsay G, Deutz NE. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009;89:142-52.
8. Marini JC, Didelija IC, Castillo L, Lee B. Glutamine: precursor or nitrogen donor for citrulline synthesis? Am J Physiol Endocrinol Metab 2010;299:E69-79.
9. Windmueller HG, Spaeth AE. Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem 1974;249:5070-9.
10. Marini JC. Quantitative analysis of 15N-labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives. Rapid CommunMass Spectrom 2011;25:1291-6.