Discovery of β-D-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 12, 2015, Pages 2484-2487

  Clarke, Michael O ^a   Mackman, Richard ^a   Byun, Daniel ^a   Hui, Hon ^a   Barauskas, Ona ^a   Birkus, Gabriel ^a   Chun, Byoung Kwon ^a   Doerffler, Edward ^a   Feng, Joy ^a   Karki, Kapil ^a   Lee, Gary ^a   Perron, Michel ^a   Siegel, Dustin ^a   Swaminathan, Swami ^a   Lee, William ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

DNA polymerase ; Mitochondria; Mitochondrial RNA polymerase; Nucleoside; Respiratory syncytial virus

Indexed keywords

ADENOSINE DERIVATIVE; ANTIVIRUS AGENT; DNA POLYMERASE; MITOCHONDRIAL RNA; NUCLEIC ACID SYNTHESIS INHIBITOR; NUCLEOSIDE ANALOG; NUCLEOSIDE TRIPHOSPHATE; ADENOSINE; DNA DIRECTED DNA POLYMERASE; HETEROCYCLIC COMPOUND; RNA; RNA DIRECTED RNA POLYMERASE; RNA, MITOCHONDRIAL;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; EC50; ENZYMATIC ASSAY; HUMAN; IC50; RESPIRATORY SYNCYTIAL VIRUS INFECTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; HUMAN RESPIRATORY SYNCYTIAL VIRUS; METABOLISM; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIRUS REPLICATION;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

ADENOSINE; ANTIVIRAL AGENTS; AZA COMPOUNDS; DNA-DIRECTED DNA POLYMERASE; DRUG EVALUATION, PRECLINICAL; NUCLEIC ACID SYNTHESIS INHIBITORS; RESPIRATORY SYNCYTIAL VIRUSES; RNA; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84929653738     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.04.073     Document Type: Article

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