A humanized monoclonal antibody against heat shock protein 60 suppresses murine arthritis and colitis and skews the cytokine balance toward an anti-inflammatory response

Journal of Immunology

Volumn 194, Issue 11, 2015, Pages 5103-5109

  Ulmansky, Rina ^a   Landstein, Dorit ^b   Moallem, Eli ^a   Loeb, Virginie ^b   Levin, Avi ^a   Meyuhas, Ronit ^b   Katzavian, Galia ^b   Yair, Shira ^b   Naparstek, Yaakov ^a,b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b ProtAb Ltd   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIRHEUMATIC AGENT; BEVACIZUMAB; CD3 ANTIBODY; CHAPERONIN 60; ETANERCEPT; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; METHYLPREDNISOLONE SODIUM SUCCINATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD28; PROZUMAB; RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; HEAT-SHOCK PROTEIN 65, MYCOBACTERIUM; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; PROTEIN BINDING;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ASSESSMENT; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; DOSE RESPONSE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; LOW DRUG DOSE; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN SYNTHESIS INHIBITION; RAT; T LYMPHOCYTE ACTIVATION; UPREGULATION; WEIGHT REDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DBA MOUSE; GENETICS; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASES; JURKAT CELL LINE; LEWIS RAT; METABOLISM; MONONUCLEAR CELL; SECRETION (PROCESS); TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; ARTHRITIS, EXPERIMENTAL; BACTERIAL PROTEINS; CELL LINE, TUMOR; CHAPERONIN 60; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-6; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; PROTEIN BINDING; RATS; RATS, INBRED LEW;

EID: 84929630175     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500023     Document Type: Article

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