Quantitative assessment and correlation analysis of cerebral microbleed distribution and Leukoaraiosis in stroke outpatients

Neurological Research

Volumn 37, Issue 5, 2015, Pages 403-409

  Yang, Qiong ^a   Yang, Yan ^a   Li, Chengyu ^a   Li, Jian ^a   Liu, Xiangyi ^a   Wang, Aonan ^a   Zhao, Jialing ^a   Wang, Mengyuan ^a   Zeng, Xiangzhu ^a   Fan, Dongsheng ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Cerebral amyloid angiopathy; Cerebral microbleeds; Distribution; Gradient recalled echo; Leukoaraiosis

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; DISEASE COURSE; DISEASE SEVERITY; FAZEKAS SCALE; FEMALE; HUMAN; HYPERTENSION; INCIDENCE; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; MICROBLEED ANATOMICAL RATING SCALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; RATING SCALE; VASCULAR AMYLOIDOSIS; BRAIN; CEREBRAL HEMORRHAGE; COMPLICATION; PATHOLOGY; SEVERITY OF ILLNESS INDEX; VASCULARIZATION;

ADULT; AGED; BRAIN; CEREBRAL HEMORRHAGE; FEMALE; HUMANS; LEUKOARAIOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; STROKE;

EID: 84929580367     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132815Y.0000000027     Document Type: Article

References (28)

1. Kakar P, Charidimou A, Werring D. Cerebral microbleeds: a new dilemma in stroke medicine. JRSM Cardiovasc Dis. 2012;1(8):22.
2. Yates P, Villemagne V, Ellis K, Desmond PM, Masters CL, Rowe CC. Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations. Front Neurol. 2014;4:205.
3. Greenberg S, Vernooij M, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 2009;8(2):165–74.
4. Saba L, Raz E, Bassareo PP, di Martino M, de Cecco CN, Mercuro G, et al. Is there an association between cerebral microbleeds and leukoaraiosis? J Stroke Cerebrovasc Dis. 2015;24(2):284–9.
5. Gahr M, Nowak DA, Connemann BJ, Schönfeldt-Lecuona C. Cerebral amyloidal angiopathy – a disease with implications for neurology and psychiatry. Brain Res. 2013;26:1519–30.
6. Ai Q, Pu YH, Sy C, Liu LP, Gao PY. Impact of regional white matter lesions on cognitive function in subcortical vascular cognitive impairment. Neurol Res. 2014;36(5):434–43.
7. Akoudad S, Ikram MA, Koudstaal PJ, Hofman A, Niessen WJ, Greenberg SM, et al. Cerebral microbleeds are associated with the progression of ischemic vascular lesions. Cerebrovasc Dis. 2014;37(5):382–8.
8. Yamada S, Saiki M, Satow T, Fukuda A, Ito M, Minami S, et al. Periventricular and deep white matter leukoaraiosis have a closer association with cerebral microbleeds than age. Eur J Neurol. 2012;19(1):98–104.
9. Gao T, Wang Y, Zhang Z. Silent cerebral microbleeds on susceptibility-weightedimaging of patients with ischemic stroke and leukoaraiosis. Neurol Res. 2008;30(3):272–6.
10. Gregoire S, Chaudhary U, Brown M, Yousry TA, Kallis C, Jäger HR, et al. The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology. 2009;73(21):1759–66.
11. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol. 1987;149(2):351–6.
12. Jeerakathil T, Wolf P, Beiser A, Hald JK, Au R, Kase CS, et al. Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke. 2004; 35(8):1831–5.
13. Takashima Y, Mori T, Hashimoto M, Kinukawa N, Uchino A, Yuzuriha T, et al. Clinical correlating factors and cognitive function in community-dwelling healthy subjects with cerebral microbleeds. J Stroke Cerebrovasc Dis. 2011;20(2):105–10.
14. Qiu C, Cotch M, Sigurdsson S, Jonsson PV, Jonsdottir MK, Sveinbjrnsdottir S, et al. Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study. Neurology. 2010; 75(24):2221–8.
15. Poels M, Vernooij M, Ikram M, Hofman A, Krestin GP, van der Lugt A, et al. Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study. Stroke. 2010;41(10 Suppl):S103–6.
16. Romero J, Preis S, Beiser A, DeCarli C, Viswanathan A, Martinez-Ramirez S, et al. Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study. Stroke. 2014;45(5):1492–4.
17. Han J, Gao P, Lin Y, Zhang J, Xu L, Xue J. Three-Tesla magnetic resonance imaging study of cerebral microbleeds in patients with ischemic stroke. Neurol Res. 2009;31(9):900–3.
18. Goos J, van der Flier W, Knol D, Pouwels PJ, Scheltens P, Barkhof F, et al. Clinical relevance of improved microbleed detection by susceptibility-weighted magnetic resonance imaging. Stroke. 2011;42(7):1894–900.
19. Nandigam R, Viswanathan A, Delgado P, Skehan ME, Smith EE, Rosand J, et al. MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength. AJNR Am J Neuroradiol. 2009;30(2):338–43.
20. Stehling C, Wersching H, Kloska S, Kirchhof P, Ring J, Nassenstein I, et al. Detection of asymptomatic cerebral microbleeds: a comparative study at 1.5 and 3.0 T. Acad Radiol. 2008;15(7):895–900.
21. Vernooij MW, Ikram MA, Wielopolski PA, Krestin GP, Breteler MM, van der Lugt A. Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection. Radiology. 2008;248(1):272–7.
22. Bai Q, Zhao Z, Sui H, Xie X, Chen J, Yang J, et al. Susceptibility-weighted imaging for cerebral microbleed detection in super-acute ischemic stroke patients treated with intravenous thrombolysis. Neurol Res. 2013;35(6):586–93.
23. Vernooij M, van der Lugt A, Ikram M, Wielopolski PA, Niessen WJ, Hofman A, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008;70(14):1208–14.
24. Soo Y, Yang S, Lam W, Wong A, Fan YH, Leung HH, et al. Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds. J Neurol. 2008;255(11): 1679–86.
25. Dierksen G, Skehan M, Khan M, Jeng J, Nandigam RN, Becker JA, et al. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol. 2010;68: 545–8.
26. Miwa K, Tanaka M, Okazaki S, Yagita Y, Sakaguchi M, Mochizuki H, et al. Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors. Neurology. 2014;83(7):646–53.
27. Zhu Y, Chabriat H, Godin O, Dufouil C, Rosand J, Greenberg SM, et al. Distribution of white matter hyperintensity in cerebral hemorrhage and healthy aging. J Neurol. 2012;259(3):530–6.
28. Arima H, Tzourio C, Anderson C, Woodward M, Bousser MG, MacMahon S, et al. Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial. Stroke. 2010;41(2): 394–6.