Interaction between smoking and nicotine acetylcholine receptor subunits alpha 5 gene rs17486278 polymorphisms on lung cancer;吸烟及烟碱型乙酰胆碱受体亚单位α5 基因rs17486278 位点多态性对肺癌的交互作用

Chinese Journal of Endemiology

Volumn 36, Issue 1, 2015, Pages 67-70

  Li, Qin ^a   Jiang, Mei ^a   Zhao, Shaojuan ^a   Wu, Xiaoying ^a   Zhou, Shanyu ^a   Liu, Tao ^a   Wang, Hui ^a   Zhang, Yalei ^b   Chen, Weiqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Gene polymorphism; Lung cancer; Nicotine acetylcholine receptor subunits alpha 5; Smoking

Indexed keywords

ARTICLE; BLOOD SAMPLING; CANCER RISK; CASE CONTROL STUDY; CHINESE; CIGARETTE SMOKING; CONTROLLED STUDY; GENE INTERACTION; GENOTYPE; HIGH RISK PATIENT; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; NICOTINE ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA 5 GENE; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURED QUESTIONNAIRE; VENOUS BLOOD; ASIAN CONTINENTAL ANCESTRY GROUP; GENETIC POLYMORPHISM; GENETICS; LUNG TUMOR; RISK; SMOKING; STATISTICAL MODEL;

NICOTINIC RECEPTOR;

ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; GENOTYPE; HUMANS; LOGISTIC MODELS; LUNG NEOPLASMS; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NICOTINIC; RISK; SMOKING;

EID: 84929519066     PISSN: 10004955     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0254-6450.2015.01.016     Document Type: Article

References (14)

1. ［1］Thorgeirsson TE，Geller F，Sulem P，et al. A variant associated with nicotine dependence，lung cancer and peripheral arterial disease［J］. Nature，2008，452（7187）：638-642.
2. ［2］Hung RJ，Mckay JD，Gaborieau V，et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25［J］. Nature，2008，452（7187）：633-637.
3. ［3］Amos CI，Wu X，Broderick P，et al. Genome-wide association scan of tag SNP identifies a susceptibility locus for lung cancer at 15q25.1［J］. Nat Genet，2008，40（5）：616-622.
4. ［4］Hansen HM，Xiao Y，Rice T，et al. Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans［J］. Hum Mol Genet，2010，19（18）：3652-3661.
5. ［5］Li Z，Bao S，Xu X，et al. Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese population［J］. Transl Oncol，2012，5（6）：448-452.
6. ［6］Wang DS. Clinical oncology［M］. 3ed. Beijing：Science Press，2010：303-304.（in Chinese）万 德 森. 临 床 肿 瘤 学［M］. 3 版. 北 京 ：科 学 出 版 社 ，2010：303-304.
7. ［7］Improgo MR，Scofield MD，Tapper AR，et al. From smoking to lung cancer the CHRNA5-A3-B4 connection ［J］. Oncogene，2010（29）：4874-4884.
8. ［8］Wassenaar C，Dong Q，Wei Q，et al. Relationship between CYP2A6 and CHRNA5-A3-B4 variation and smoking behaviors and lung cancer risk［J］. J Natl Cancer Inst，2011，103（17）：1342-1346.
9. ［9］Schuller H. Is cancer triggered by altered signalling of nicotinic acetylcholine receptors？［J］. Nat Rev Cancer，2009，9（3）：195-205.
10. ［10］Wu C，Hu Z，Yu D，et al. Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations［J］. Cancer Res，2009，69（12）：5065-5072.
11. ［11］Wang Y，Broderick P，Webb E，et al. Common 5p15.33 and 6p21.33 variants influence lung cancer risk［J］. Nat Genet，2008，40（12）：1407-1409.
12. ［12］Amos CI，Gorlov IP，Dong Q，et al. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans：a case-control study［J］. J Natl Cancer Inst，2010，102（15）：1199-1205.
13. ［13］Wei C，Han Y，Spitz MR，et al. A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk ［J］. Cancer Epidemiol Biomarkers Prev，2011，20（12）：2603-2609.
14. ［14］Shen B，Zhu Q，Zheng MQ，et al. CHRNA5 polymorphism and susceptibility to lung cancer in a Chinese population［J］. Braz J Med Biol Res，2013，46（1）：79-84.