Antimüllerian hormone levels decrease in female-to-male transsexuals using testosterone as cross-sex therapy

Fertility and Sterility

Volumn 103, Issue 5, 2015, Pages 1340-1345

  Caanen, Mirte R ^a   Soleman, Remi S ^a   Kuijper, Esther A M ^a   Kreukels, Baudewijntje P C ^a   De Roo, Chloë ^b   Tilleman, Kelly ^b   De Sutter, Petra ^b   Van Trotsenburg, Mick A A ^a   Broekmans, Frank J ^c   Lambalk, Cornelis B ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

androgens; Antim llerian hormone; folliculogenesis; polycystic ovary syndrome; transgender

Indexed keywords

ANDROSTENEDIONE; ESTRADIOL; FOLLITROPIN; GONADOTROPIN; INHIBIN B; LETROZOLE; LUTEINIZING HORMONE; MUELLERIAN INHIBITING FACTOR; PRASTERONE SULFATE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; STEROID; TESTOSTERONE; TRIPTORELIN; ANDROGEN; AROMATASE INHIBITOR; BIOLOGICAL MARKER; GONADORELIN;

ADULT; ARTICLE; COHORT ANALYSIS; CONCENTRATION RESPONSE; CROSS SEX HORMONE THERAPY; ESTROGEN SYNTHESIS; FEMALE; FEMALE TO MALE TRANSGENDER; GENDER DYSPHORIA; HORMONAL THERAPY; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX HORMONE DETERMINATION; SEX REASSIGNMENT; SEX THERAPY; TERTIARY CARE CENTER; VIRILIZATION; ADOLESCENT; AGONISTS; BLOOD; DOWN REGULATION; DRUG EFFECTS; MALE; METABOLISM; OVARY; PROCEDURES; TIME; TRANSSEXUALISM; TREATMENT OUTCOME; UNIVERSITY HOSPITAL; YOUNG ADULT;

ACADEMIC MEDICAL CENTERS; ADOLESCENT; ADULT; ANDROGENS; ANTI-MULLERIAN HORMONE; AROMATASE INHIBITORS; BIOLOGICAL MARKERS; DOWN-REGULATION; FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; MALE; OVARY; PROSPECTIVE STUDIES; SEX REASSIGNMENT PROCEDURES; TERTIARY CARE CENTERS; TESTOSTERONE; TIME FACTORS; TRANSSEXUALISM; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84929510142     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2015.02.003     Document Type: Article

References (50)

1. N. Josso, I. Lamarre, J.Y. Picard, P. Berta, N. Davies, and N. Morichon Anti-müllerian hormone in early human-development Early Hum Dev 33 1993 91 99
2. D. Dewailly, C.Y. Andersen, A. Balen, F. Broekmans, N. Dilaver, and R. Fanchin The physiology and clinical utility of anti-müllerian hormone in women Hum Reprod Update 20 2014 370 385
3. R. Fanchin, L.M. Schonauer, C. Righini, J. Guibourdenche, R. Frydman, and J. Taieb Serum anti-müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3 Hum Reprod 18 2003 323 327
4. E.A. Knauff, M.J. Eijkemans, C.B. Lambalk, M.J. ten Kate-Booij, A. Hoek, and C.C. Beerendonk Anti-müllerian hormone, inhibin B, and antral follicle count in young women with ovarian failure J Clin Endocrinol Metab 95 2010 786 792
5. I.A. van Rooij, F.J. Broekmans, E.R. te Velde, B.C. Fauser, L.F. Bancsi, and F.H. de Jong Serum anti-müllerian hormone levels: a novel measure of ovarian reserve Hum Reprod 17 2002 3065 3071
6. J.A. Visser, F.H. de Jong, J.S. Laven, and A.P. Themmen Anti-müllerian hormone: a new marker for ovarian function Reproduction 131 2006 1 9
7. J.A. Visser, and A.P. Themmen Anti-müllerian hormone and folliculogenesis Mol Cell Endocrinol 234 2005 81 86
8. J.V. Jeppesen, R.A. Anderson, T.W. Kelsey, S.L. Christiansen, S.G. Kristensen, and K. Jayaprakasan Which follicles make the most anti-Mllerian hormone in humans? Evidence for an abrupt decline in AMH production at the time of follicle selection Mol Hum Reprod 19 2013 519 527
9. M.E. Kevenaar, M.F. Meerasahib, P. Kramer, B.M. de Lang-Born, F.H. de Jong, and N.P. Groome Serum antimullerian hormone levels reflect the size of the primordial follicle pool in mice Endocrinology 147 2006 3228 3234
10. K.R. Hansen, G.M. Hodnett, N. Knowlton, and L.B. Craig Correlation of ovarian reserve tests with histologically determined primordial follicle number Fertil Steril 95 2011 170 175
11. C.L. Cook, Y. Siow, A.G. Brenner, and M.E. Fallat Relationship between serum müllerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women Fertil Steril 77 2002 141 146
12. J.S. Laven, A.G. Mulders, J.A. Visser, A.P. Themmen, F.H. de Jong, and B.C. Fauser Anti-müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age J Clin Endocrinol Metab 89 2004 318 323
13. Y.H. Lin, W.C. Chiu, C.H. Wu, C.R. Tzeng, C.S. Hsu, and M.I. Hsu Antimüllerian hormone and polycystic ovary syndrome Fertil Steril 96 2011 230 235
14. A.S. Park, M.A. Lawson, S.S. Chuan, S.E. Oberfield, K.M. Hoeger, and S.F. Witchel Serum antimüllerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism J Clin Endocrinol Metab 95 2010 1786 1792
15. P. Pigny, E. Merlen, Y. Robert, C. Cortet-Rudelli, C. Decanter, and S. Jonard Elevated serum level of antimüllerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest J Clin Endocrinol Metab 88 2003 5957 5962
16. T. Piltonen, L. Morin-Papunen, R. Koivunen, A. Perheentupa, A. Ruokonen, and J.S. Tapanainen Serum anti-müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome Hum Reprod 20 2005 1820 1826
17. S. Franks Polycystic ovary syndrome in adolescents Int J Obes 32 2008 1035 1041
18. R.J. Norman, D. Dewailly, R.S. Legro, and T.E. Hickey Polycystic ovary syndrome Lancet 370 2007 685 697
19. F.J. Broekmans, and B.C. Fauser Diagnostic criteria for polycystic ovarian syndrome Endocrine 30 2006 3 11
20. C.G. Gervasio, M.P. Bernuci, M.F. Silva-de-Sa, and A.C. Rosa-e-Silva The role of androgen hormones in early follicular development ISRN Obstet Gynecol 2014 2014 818010
21. M. Otala, S. Makinen, T. Tuuri, J. Sjoberg, V. Pentikainen, and T. Matikainen Effects of testosterone, dihydrotestosterone, and 17 beta-estradiol on human ovarian tissue survival in culture Fertil Steril 82 2004 1077 1085
22. M. Tetsuka, and S.G. Hillier Differential regulation of aromatase and androgen receptor in granulosa cells J Steroid Biochem Mol Biol 61 1997 233 239
23. K. Vendola, J. Zhou, J. Wang, O.A. Famuyiwa, M. Bievre, and C.A. Bondy Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary Biol Reprod 61 1999 353 357
24. K.A. Vendola, J. Zhou, O.O. Adesanya, S.J. Weil, and C.A. Bondy Androgens stimulate early stages of follicular growth in the primate ovary J Clin Invest 101 1998 2622 2629
25. D. Dewailly, P. Pigny, C. Decanter, and Y. Robert Elevated serum level of antimullerian hormone (AMH) in polycystic ovary syndrome (PCOS): relationship to the ovarian follicle excess and to the serum FSH and to the follicular arrest Fertil Steril 80 2003 S276
26. S. Jonard, and D. Dewailly The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest Hum Reprod Update 10 2004 107 117
27. F.J. Broekmans, J.A. Visser, J.S. Laven, S.L. Broer, A.P. Themmen, and B.C. Fauser Anti-müllerian hormone and ovarian dysfunction Trends Endocrinol Metab 19 2008 340 347
28. A.L. Durlinger, J.A. Visser, and A.P. Themmen Regulation of ovarian function: the role of anti-müllerian hormone Reproduction 124 2002 601 609
29. A.A. Murray, R.G. Gosden, V. Allison, and N. Spears Effect of androgens on the development of mouse follicles growing in vitro J Reprod Fertil 113 1998 27 33
30. S. Weil, K. Vendola, J. Zhou, and C.A. Bondy Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development J Clin Endocrinol Metab 84 1999 2951 2956
31. D.H. Abbott, D.A. Dumesic, J.R. Eisner, R.J. Colman, and J.W. Kemnitz Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys Trends Endocrinol Metab 9 1998 62 67
32. W. Futterweit, and L. Deligdisch Histopathological effects of exogenously administered testosterone in 19 female to male-transsexuals J Clin Endocrinol Metab 62 1986 16 21
33. T.D. Pache, S. Chadha, L.J. Gooren, W.C. Hop, K.W. Jaarsma, and H.B. Dommerholt Ovarian morphology in long-term androgen-treated female to male-transsexuals - a human-model for the study of polycystic ovarian syndrome Histopathology 19 1991 445 452
34. T. Spinder, J.J. Spijkstra, J.G. Vandentweel, C.W. Burger, H. Vankessel, and P.G. Hompes The effects of long-term testosterone administration on pulsatile luteinizing-hormone secretion and on ovarian histology in eugonadal female to male-transsexual subjects J Clin Endocrinol Metab 69 1989 151 157
35. K. Ikeda, T. Baba, H. Noguchi, K. Nagasawa, T. Endo, and T. Kiya Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology Hum Reprod 28 2013 453 461
36. H. Billig, I. Furuta, and A.J. Hsueh Estrogens inhibit and androgens enhance ovarian granulosa-cell apoptosis Endocrinology 133 1993 2204 2212
37. R.S. Soleman, A.S. Staphorsius, P.T. Cohen-Kettenis, C.B. Lambalk, D.J. Veltman, and M.A. van Trotsenbrug Oestrogens are not related to emotional processing: a study of regional brain activity in female-to-male transsexuals under gonadal suppression Cereb Cortex 2014 Sep 22
38. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 2000 American Psychiatric Association Washington, D.C.
39. K. Jayaprakasan, B.K. Campbell, J.F. Hopkisson, J.S. Clewes, I.R. Johnson, and N.J. Raine-Fenning Effect of pituitary desensitization on the early growing follicular cohort estimated using anti-müllerian hormone Hum Reprod 23 2008 2577 2583
40. K.A. Mohamed, W.A. Davies, and H. Lashen Antimfullerian hormone and pituitary gland activity after prolonged down-regulation with goserelin acetate Fertil Steril 86 2006 1515 1517
41. H.I. Su, K. Maas, P.M. Sluss, R.J. Chang, J.E. Hall, and H. Joffe The Impact of depot GnRH agonist on AMH levels in healthy reproductive-aged women J Clin Endocrinol Metab 98 2013 E1961 E1966
42. C.P. Hagen, K. Sorensen, R.A. Anderson, and A. Juul Serum levels of antimullerian hormone in early maturing girls before, during, and after suppression with GnRH agonist Fertil Steril 98 2012 1326 1330
43. C.Y. Andersen, and K. Lossl Increased intrafollicular androgen levels affect human granulosa cell secretion of anti-müllerian hormone and inhibin-B Fertil Steril 89 2008 1760 1765
44. K. Lossl, A.N. Andersen, A. Loft, N.L. Freiesleben, S. Bangsboll, and C.Y. Andersen Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols Hum Reprod 21 2006 2593 2600
45. C. de Roo, S. Lierman, K. Tilleman, M. Cornelissen, S. Weyers, and G. t'Sjoen Anti-müllerian hormone (AMH) serum levels are correlated with the number of primary follicles in ovaries of female-to-male transgender persons Hum Reprod 29 Suppl 1 2014 86
46. M.A. van Trotsenburg Gynaecological aspects of transgender healthcare Int J Transgenderism 11 2009 238 246
47. N. Crisosto, T. Sir-Petermann, M. Greiner, M. Maliqueo, M. Moreno, and P. Aedo Testosterone-induced downregulation of anti-Mullerian hormone expression in granulosa cells from small bovine follicles Endocrine 36 2009 339 345
48. L. Manneras, S. Cajander, A. Holmang, Z. Seleskovic, T. Lystig, and M. Lohn A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome Endocrinology 148 2007 3781 3791
49. M. Maliqueo, M. Sun, J. Johansson, A. Benrick, F. Labrie, and H. Svensson Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age Endocrinology 154 2013 434 445
50. L. Pellatt, L. Hanna, M. Brincat, R. Galea, H. Brain, and S. Whitehead Granulosa cell production of anti-müllerian hormone is increased in polycystic ovaries J Clin Endocrinol Metab 92 2007 240 245