In silico prediction of the T-cell and IgE-binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches

Molecular Medicine Reports

Volumn 10, Issue 4, 2014, Pages 2130-2136

  Chen, Hao ^a,b   Yang, Hai Wei ^b   Wei, Ji Fu ^a,b   Tao, Ai Lin ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

B cell epitopes; Bla g 6; Immunoinformatics prediction; Per a 6; T cell epitopes

Indexed keywords

ALLERGEN; BLATTELLA GERMANICA 6 ALLERGEN; EPITOPE; IMMUNOGLOBULIN E; PERIPLANETA AMERICANA 6 ALLERGEN; UNCLASSIFIED DRUG; PEPTIDE; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANOPHELES GAMBIAE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; BLATTELLA GERMANICA; BOMBYX MORI; COCKROACH; COMPUTER MODEL; CULEX QUINQUEFASCIATUS; DROSOPHILA; DROSOPHILA GRIMSHAWI; DROSOPHILA MELANOGASTER; DROSOPHILA SIMULANS; DROSOPHILA VIRILIS; DROSOPHILA WILLISTONI; DROSOPHILA YAKUBA; HYDROPHILICITY; HYDROPHOBICITY; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PEA APHID; PERIPLANETA AMERICANA; PHYLOGENY; PLUTELLA XYLOSTELLA; PREDICTION; SOLENOPSIS INVICTA; T LYMPHOCYTE; ANIMAL; BIOLOGY; CHEMISTRY; CLASSIFICATION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT;

ALLERGENS; AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; COCKROACHES; COMPUTATIONAL BIOLOGY; EPITOPES; IMMUNOGLOBULIN E; MOLECULAR SEQUENCE DATA; PEPTIDES; PHYLOGENY; PROTEIN BINDING; SEQUENCE ALIGNMENT; T-LYMPHOCYTES;

EID: 84929505821     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2399     Document Type: Article

References (39)

1. Bernton HS and Brown H: Insect allergy - preliminary studies of the cockroach. J Allergy 35: 506-513, 1964.
2. Arruda LK, Vailes LD, Ferriani VP, Santos AB, Pomés A and Chapman MD: Cockroach allergens and asthma. J Allergy Clin Immunol 107: 419-428, 2001. (Pubitemid 32210020)
3. Sun BQ, Lai XX, Gjesing B, Spangfort MD and Zhong NS: Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma. Chin Med J (Engl) 123: 3540-3544, 2010.
4. He S, Zhang Z, Zhang H, et al: Analysis of properties and proin-flammatory functions of cockroach allergens Per a 1.01s. Scand J Immunol 74: 288-295, 2011.
5. Pan QR, Wang SM, Shang HS and Chew FT: Identification and characterization of Per a 2, the Bla g 2 allergen homologue from American cockroach (Periplaneta americana). J Allergy Clin Immunol 117: S115, 2006.
6. Tan YW, Chan SL, Ong TC, et al: Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes. J Biol Chem 284: 3148-3157, 2009.
7. Khantisitthiporn O, Sookrung N, Tungtrongchitr A, et al: Native troponin-T of the American cockroach (CR), Periplaneta americana, binds to IgE in sera of CR allergic Thais. Asian Pac J Allergy Immunol 25: 189-197, 2007. (Pubitemid 351384962)
8. Asturias JA, Gómez-Bayón N, Arilla MC, et al: Molecular characterization of American cockroach tropomyosin (Periplaneta americana allergen 7), a cross-reactive allergen. J Immunol 162: 4342-4348, 1999. (Pubitemid 29314827)
9. Sookrung N, Chaicumpa W, Tungtrongchitr A, et al: Periplaneta americana arginine kinase as a major cockroach allergen among Thai patients with major cockroach allergies. Environ Health Perspect 114: 875-880, 2006. (Pubitemid 43871737)
10. Sudha VT, Arora N, Gaur SN, Pasha S and Singh BP: Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy 63: 768-776, 2008. (Pubitemid 351591845)
11. Sookrung N and Chaicumpa W: A revisit to cockroach allergens. Asian Pac J Allergy Immunol 28: 95-106, 2010.
12. Kang BC, Johnson J, Morgan C and Chang JL: The role of immunotherapy in cockroach asthma. J Asthma 25: 205-218, 1988.
13. Srivastava D, Gaur SN, Arora N and Singh BP: Clinico-immunological changes post-immunotherapy with Periplaneta americana. Eur J Clin Invest 41: 879-888, 2011.
14. Sharma V, Singh BP, Gaur SN, Pasha S and Arora N: Bioinformatics and immunologic investigation on B and T cell epitopes of Cur I 3, a major allergen of Curvularia lunata. J Proteome Res 8: 2650-2655, 2009.
15. Wang HW, Lin YC, Pai TW and Chang HT: Prediction of B-cell linear epitopes with a combination of support vector machine classification and amino acid propensity identification. J Biomed Biotechnol 2011: 432830, 2011.
16. Jiminez-Lopez JC, Kotchoni SO, Rodríguez-García MI and Alché JD: Structure and functional features of olive pollen pectin methylesterase using homology modeling and molecular docking methods. J Mol Model 18: 4965-4984, 2012.
17. Nielsen M, Lund O, Buus S and Lundegaard C: MHC class II epitope predictive algorithms. Immunology 130: 319-328, 2010.
18. Larkin MA, Blackshields G, Brown NP, et al: Clustal W and Clustal X version 2.0. Bioinformatics 23: 2947-2948, 2007. (Pubitemid 350162903)
19. Kumar S, Nei M, Dudley J and Tamura K: MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform 9: 299-306, 2008. (Pubitemid 351890826)
20. Hopp TP and Woods KR: Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci USA 78: 3824-3828, 1981. (Pubitemid 11060471)
21. Kyte J and Doolittle RF: A simple method for displaying the hydropathic character of a protein. J Mol Biol 157: 105-132, 1982.
22. Karplus PA and Schulz GE: Prediction of chain flexibility in proteins. Naturwissenschaften 72: 212-213, 1985.
23. Emini EA, Hughes JV, Perlow D and Boger J: Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol 55: 836-839, 1985. (Pubitemid 16254565)
24. Jameson B and Wolf H: The antigenic index: a novel algorithm for predicting antigenic determinants. Comput Appl Biosci 4: 181-186, 1988. (Pubitemid 18072035)
25. Kolaskar A and Tongaonkar PC: A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett 276: 172-174, 1990.
26. Larsen JE, Lund O and Nielsen M: Improved method for predicting linear B-cell epitopes. Immunome Res 2: 2, 2006.
27. Zheng LN, Lin H, Pawar R, Li ZX and Li MH: Mapping IgE binding epitopes of major shrimp (Penaeus monodon) allergen with immunoinformatics tools. Food Chem Toxicol 49: 2954-2960, 2011.
28. Yang X and Yu X: An introduction to epitope prediction methods and software. Rev Med Virol 19: 77-96, 2009.
29. Rammensee HG, Friede T and Stevanoviíc S: MHC ligands and peptide motifs: first listing. Immunogenetics 41: 178-228, 1995.
30. Nielsen M and Lund O: NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction. BMC Bioinformatics 10: 296, 2009.
31. Wang P, Sidney J, Kim Y, et al: Peptide binding predictions for HLA DR, DP and DQ molecules. BMC Bioinformatics 11: 568, 2010.
32. Pascal M, Konstantinou GN, Masilamani M, Lieberman J and Sampson HA: In silico prediction of Ara h 2 T cell epitopes in peanut-allergic children. Clin Exp Allergy 43: 116-127, 2013.
33. Baena-Cagnani CE, Serra H, Teijeiro A and Croce JS: Prevention of allergy and asthma. Clin Exp Allergy Rev 3: 51-57, 2003. (Pubitemid 36241366)
34. Moldaver D and Larché M: Immunotherapy with peptides. Allergy 66: 784-791, 2011.
35. Lin J, Bardina L, Shreffler WG, et al: Development of a novel peptide microarray for large-scale epitope mapping of food allergens. J Allergy Clin Immunol 124: 315-322, 2009.
36. Li GF, Wang Y, Zhang ZS, et al: Identification of immunodominant Th1-type T cell epitopes from Schistosoma japonicum 28 kDa glutathione-S-transferase, a vaccine candidate. Acta Biochim Biophys Sin (Shanghai) 37: 751-758, 2005. (Pubitemid 44890985)
37. Nair S, Kukreja N, Singh BP and Arora N: Identification of B cell epitopes of alcohol dehydrogenase allergen of Curvularia lunata. PLoS One 6: e20020, 2011.
38. Pomés A: Relevant B cell epitopes in allergic disease. Int Arch Allergy Immunol 152: 1-11, 2010.
39. Nielsen M, Justesen S, Lund O, Lundegaard C and Buus S: NetMHCIIpan-2.0 - Improved pan-specific HLA-DR predictions using a novel concurrent alignment and weight optimization training procedure. Immunome Res 6: 9, 2010.