Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: Studies in a rat stroke model

International Journal of Stroke

Volumn 10, Issue 4, 2015, Pages 553-559

  Mcleod, D D ^a   Parsons, M W ^b   Hood, R ^a   Hiles, B ^a   Allen, J ^a   Mccann, S K ^a   Murtha, L ^a   Calford, M B ^a   Levi, C R ^b   Spratt, N J ^a,b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

Author keywords

Infarct core; Ischemic penumbra; Perfusion computed tomography

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN SCINTISCANNING; CEREBRAL BLOOD FLOW THRESHOLD; CEREBROVASCULAR ACCIDENT; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; HISTOPATHOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PENUMBRA ISCHEMIA; PERFUSION COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; RAT; REPERFUSION; ANIMAL; BRAIN; BRAIN CIRCULATION; CEREBRAL ARTERY DISEASE; DISEASE MODEL; OUTBRED STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RADIOGRAPHY; RECEIVER OPERATING CHARACTERISTIC; SCINTIGRAPHY; TIME; WISTAR RAT;

ANIMALS; ANIMALS, OUTBRED STRAINS; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; PERFUSION IMAGING; RATS, WISTAR; ROC CURVE; STROKE; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84929505015     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/ijs.12147     Document Type: Article

References (13)

1. Bivard A, Spratt N, Levi C, Parsons M. Perfusion computer tomography: imaging and clinical validation in acute ischaemic stroke. Brain 2011; 134(Pt 11):3408-3416.
2. Spratt NJ, Fernandez J, Chen M etal. Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats. J Neurosci Methods 2006; 155:285-290.
3. McLeod DD, Parsons MW, Levi CR etal. Establishing a rodent stroke perfusion computed tomography model. International journal of stroke: official journal of the International Stroke. Society 2011; 6:284-289.
4. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia: the ischemic penumbra. Stroke 1981; 12:723-725.
5. Hossmann KA. Viability thresholds and the penumbra of focal ischemia. Ann Neurol 1994; 36:557-565.
6. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke 2007; 38:2779-2786.
7. Ames A, 3rd, Wright RL, Kowada M, Thurston JM, Majno G. Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 1968; 52:437-453.
8. Liu S, Connor J, Peterson S, Shuttleworth CW, Liu KJ. Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion. J Cerebral Blood Flow Metab 2002; 22:1222-1230.
9. Mori E, del Zoppo GJ, Chambers JD, Copeland BR, Arfors KE. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons. Stroke 1992; 23:712-718.
10. Touzani O, Baron JC. Duration and thresholds of the ischemic penumbra in different species; in Donnan GA, Baron JC, Davis SM, Sharp FR (eds). The Ischemic Penumbra. New York, Informa Healthcare USA, Inc., 2007:37-58.
11. Oliff HS, Weber E, Eilon G, Marek P. The role of strain/vendor differences on the outcome of focal ischemia induced by intraluminal middle cerebral artery occlusion in the rat. Brain Res 1995; 675:20-26.
12. Ma J, Zhao L, Nowak TS, Jr. Selective, reversible occlusion of the middle cerebral artery in rats by an intraluminal approach optimized filament design and methodology. J Neurosci Methods 2006; 156:76-83.
13. Zhang K, Sejnowski TJ. A universal scaling law between gray matter and white matter of cerebral cortex. Proc Natl Acad Sci U S A 2000; 97:5621-5626.