Bone marrow findings of the newly described TEMPI syndrome: When erythrocytosis and plasma cell dyscrasia coexist

Modern Pathology

Volumn 28, Issue 3, 2015, Pages 367-372

  Rosado, Flavia G ^a   Oliveira, Jennifer L ^a   Sohani, Aliya R ^b   Schroyens, Wilfried ^c   Sykes, David B ^b   Kenderian, Saad S ^a   Lacy, Martha Q ^a   Kyle, Robert A ^a   Hoyer, James D ^a  

^a MAYO CLINIC   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; IMMUNOGLOBULIN KAPPA CHAIN; PARAPROTEIN; VASCULOTROPIN;

ADULT; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; CELL VACUOLE; CLINICAL EVALUATION; DIFFERENTIAL DIAGNOSIS; ERYTHROCYTOSIS; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; IRON DEFICIENCY ANEMIA; MALE; MEGAKARYOCYTE; PLASMA CELL; PLASMA CELL DYSCRASIA; POEMS SYNDROME; POLYCYTHEMIA VERA; PRIORITY JOURNAL; SCHNITZLER SYNDROME; TEMPI SYNDROME; BONE MARROW; MIDDLE AGED; PARAPROTEINEMIA; PATHOLOGY; POLYCYTHEMIA; SYNDROME;

ADULT; BONE MARROW; FEMALE; HUMANS; MALE; MIDDLE AGED; PARAPROTEINEMIAS; POLYCYTHEMIA; SYNDROME;

EID: 84929504174     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2014.117     Document Type: Article

References (18)

1. Sykes DB, Schroyens W, O'Connell C. TEMPI Syndrome-A novel multisystem disease. N Engl J Med 2011;365:475-477
2. Kwok M, Korde N, Landgren O. Bortezomib to treat the TEMPI syndrome. N Engl J Med 2012;366:1843-1845
3. Mohammadi F, Wolverson MK, Bastani B. A new case of TEMPI syndrome. Clin Kidney J 2012;5:556-558
4. Viglietti D, Sverzut JM, Peraldi MN. Perirenal fluid collections and monoclonal gammopathy. Nephrol Dial Transplant 2012;27:448-449
5. Ryden A,Wei K, Rodriguez R, et al. Too Much Blood: A Case of the Newly Described TEMPI Syndrome. Chest 2013, 144:4 (meeting abstracts)
6. Schroyens WA, O'Connell CL, Lacy MQ, et al. TEMPI a reversible syndrome following treatment with bortezomib. Blood 2012; 367:778-780
7. Schroyens W, O'Connell C, Sykes DB. Complete and partial responses of the TEMPI syndrome to bortezomib. N Engl J Med 2012;367:778-780
8. Pralle H, Schröder R, Lö ffler H. New kind of cytoplasmic inclusions of plasma cells in acid maltase deficiency. Acta Haematol 1975;53:109-117
9. Liapis K, Apostolidis J. Empty, but heavy, plasma cells. Blood 2012;120:4282
10. Merlini GL, Palladini G. Differential diagnosis of monoclonal gammopathy of undetermined significance. Hematology Am Soc Hematol Educ Program 2012;2012:595-603
11. de Koning HD, Bodar EJ, van der Meer JW, et al. Schnitzler Syndrome Study Group. Schnitzler syndrome: beyond the case reports: review and follow-up of 94 patients with an emphasis on prognosis and treatment. Semin Arthritis Rheum 2007;37:137-148
12. Dao LN, Hanson CA, Dispenzieri A, et al. Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients. Blood 2011;117: 6438-6444
13. Lipsker D. The Schnitzler syndrome. Orphanet J Rare Dis 2010;5:38
14. Jain T, Offord CP, Kyle RA, et al. Schnitzler syndrome: an under-diagnosed clinical entity. Haematologica 2013;98:1581-1585
15. Scarlato M, Carpo M, Previtali S, et al. Poems syndrome: role of two angiogenic factors, VEGF and EPO. J Peripher Nerv Syst 2004;9:110
16. Bond J, Gale DP, Connor T, et al. Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension. Blood 2011;117:3699-3701
17. Mossuz P, Girodon F, Donnard M, et al. Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis. Haematologica 2004;89:1194-1198
18. Al-Tourah AJL, Tsang PW, Skinnider BF, et al. Paraneoplastic erythropoietin-induced polycythemia associated with small lymphocytic lymphoma. J Clin Oncol 2006;24:2388-2389.