Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Cui, He ^a   Wang, Ling ^a   Gong, Pihai ^a   Zhao, Chengcheng ^a   Zhang, Shaodan ^a   Zhang, Kun ^b   Zhou, Rongping ^c   Zhao, Zhujiang ^a   Fan, Hong ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A; MICRORNA; MICRORNA 29B; MICRORNA 29C; UNCLASSIFIED DRUG; CADHERIN; CDH1 PROTEIN, HUMAN; DNA (CYTOSINE 5) METHYLTRANSFERASE; LUCIFERASE; MIRN29 MICRORNA, HUMAN;

ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CDH1 GENE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; DNA FLANKING REGION; DNA METHYLATION; DNMT3A GENE; EPIGENETICS; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS; MOLECULAR INTERACTION; PHENOTYPE; STOMACH CANCER; WOUND HEALING; BIOASSAY; CANCER STAGING; CELL DIFFERENTIATION; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELL LINE;

BIOLOGICAL ASSAY; CADHERINS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, REPORTER; HUMANS; LUCIFERASES; MALE; MICRORNAS; NEOPLASM STAGING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; WOUND HEALING;

EID: 84929485945     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123926     Document Type: Article

References (36)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61: 69-90. doi: 10.3322/caac.20107 PMID: 21296855
2. Lordick F, Siewert JR. Recent advances in multimodal treatment for gastric cancer: a review. Gastric Cancer. 2005; 8: 78-85. PMID: 15864714
3. Maehara Y, Moriguchi S, Kakeji Y, Kohnoe S, Korenaga D, Haraguchi M, et al. Pertinent risk factors and gastric carcinoma with synchronous peritoneal dissemination or liver metastasis. Surgery. 1991; 110: 820-823. PMID: 1948650
4. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136: 215-233. doi: 10. 1016/j.cell.2009.01.002 PMID: 19167326
5. Zhang H, Li Y, Lai M. The microRNA network and tumor metastasis. Oncogene. 2010; 29: 937-948. doi: 10.1038/onc.2009.406 PMID: 19935707
6. Cho WC. OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer. 2007; 6: 60. PMID: 17894887
7. Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic acids research. 2005; 33: 1290-1297. PMID: 15741182
8. Xia J, Guo X, Yan J, Deng K. The role of miR-148a in gastric cancer. J Cancer Res Clin Oncol. 2014; 140: 1451-1456. PMID: 24659367
9. Fesler A, Zhai H, Ju J. miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer. Onco Targets Ther. 2014; 7: 1481-1485. doi: 10.2147/OTT.S65548 PMID: 25187728
10. Wang JL, Hu Y, Kong X, Wang ZH, Chen HY, Xu J, et al. Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. PloS one. 2013; 8: e73683. doi: 10.1371/journal.pone.0073683 PMID: 24040025
11. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, et al. MicroRNA 29b functions in acute myeloid leukemia. Blood. 2009; 114: 5331-5341. doi: 10.1182/blood-2009-03-211938 PMID: 19850741
12. Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, et al. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proceedings of the National Academy of Sciences. 2008; 105: 5874-5878. doi: 10.1073/pnas.0801130105 PMID: 18390668
13. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proceedings of the National Academy of Sciences. 2007; 104: 15805-15810. PMID: 17890317
14. Gong J, Li J, Wang Y, Liu C, Jia H, Jiang C, et al. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis. 2014; 35: 497-506. doi: 10.1093/carcin/bgt337 PMID: 24130168
15. Lang N, Liu M, Tang QL, Chen X, Liu Z, Bi F. Effects of microRNA-29 family members on proliferation and invasion of gastric cancer cell lines. Chin J Cancer. 2010; 29: 603-610. PMID: 20507733
16. Wang Y, Zhang X, Li H, Yu J, Ren X. The role of miRNA-29 family in cancer. Eur J Cell Biol. 2013; 92: 123-128. doi: 10.1016/j.ejcb.2012.11.004 PMID: 23357522
17. Mott JL, Kurita S, Cazanave SC, Bronk SF, Werneburg NW, Fernandez-Zapico ME. Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem. 2010; 110: 1155-1164. doi: 10.1002/jcb.22630 PMID: 20564213
18. Han L, Witmer PD, Casey E, Valle D, Sukumar S. DNA methylation regulates MicroRNA expression. Cancer Biol Ther. 2007; 6: 1284-1288. PMID: 17660710
19. Lujambio A, Esteller M. CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle. 2007; 6: 1455-1459. PMID: 17581274
20. Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 2007; 67: 1424-1429. PMID: 17308079
21. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, et al. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol. 2010; 11: 136-146. doi: 10.1016/S1470-2045(09)70343-2 PMID: 20022810
22. Tsai KW, Wu CW, Hu LY, Li SC, Liao YL, Lai CH, et al. Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. Int J Cancer. 2011; 129: 2600-2610. doi: 10.1002/ijc.25919 PMID: 21960261
23. Ando T, Yoshida T, Enomoto S, Asada K, Tatematsu M, Ichinose M, et al. DNA methylation of micro- RNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer. 2009; 124: 2367-2374. doi: 10.1002/ijc.24219 PMID: 19165869
24. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, et al. Real-time quantification of micro- RNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005; 33: e179. PMID: 16314309
25. Zhao Z, Wu Q, Cheng J, Qiu X, Zhang J, Fan H. Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell. J Biomed Biotechnol. 2010; 2010: 737535. doi: 10.1155/2010/737535 PMID: 20467490
26. Rodriguez LG, Wu X, Guan JL. Wound-healing assay. Methods Mol Biol. 2005; 294: 23-29. PMID: 15576902
27. Weissmann-Brenner A, Kushnir M, Lithwick Yanai G, Aharonov R, Gibori H, Purim O, et al. Tumor microRNA-29a expression and the risk of recurrence in stage II colon cancer. Int J Oncol. 2012; 40: 2097-2103. doi: 10.3892/ijo.2012.1403 PMID: 22426940
28. Ru P, Steele R, Newhall P, Phillips NJ, Toth K, Ray RB. miRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signaling. Mol Cancer Ther. 2012; 11: 1166-1173. doi: 10.1158/1535-7163.MCT-12-0100 PMID: 22402125
29. Wang H, Zhu Y, Zhao M, Wu C, Zhang P, Tang L, et al. miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin beta1 and matrix metalloproteinase2 (MMP2). PLoS One. 2013; 8: e70192. doi: 10.1371/journal.pone.0070192 PMID: 23936390
30. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 2008; 40: 43-50. PMID: 18066065
31. Eyholzer M, Schmid S, Wilkens L, Mueller BU, Pabst T. The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML. Br J Cancer. 2010; 103: 275-284. doi: 10.1038/sj.bjc.6605751 PMID: 20628397
32. Yang J, Wei X, Wu Q, Xu Z, Gu D, Jin Y, et al. Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer. Mol Med Rep. 2011; 4: 1139-1143. doi: 10.3892/mmr.2011.578 PMID: 21887466
33. Ding WJ, Fang JY, Chen XY, Peng YS. The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer. Dig Dis Sci. 2008; 53: 2083-2089. doi: 10.1007/s10620-007-0145-2 PMID: 18253830
34. Cao XY, Ma HX, Shang YH, Jin MS, Kong F, Jia ZF, et al. DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer. World J Gastroenterol. 2014; 20: 8201-8208. doi: 10.3748/wjg.v20.i25.8201 PMID: 25009393
35. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139: 871-890. doi: 10.1016/j.cell.2009.11.007 PMID: 19945376
36. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, et al. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst. 2000; 92: 569-573. PMID: 10749913