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Angewandte Chemie - International Edition

Volumn 54, Issue 19, 2015, Pages 5596-5602

Biology-oriented synthesis of a withanolide-inspired compound collection reveals novel modulators of hedgehog signaling

(9) Švenda, Jakub a Sheremet, Michael a,b Kremer, Lea a Maier, Lukáš a,b Bauer, Jonathan O b Strohmann, Carsten b Ziegler, Slava a Kumar, Kamal a,b Waldmann, Herbert a,b

a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY (Germany)

b TU DORTMUND UNIVERSITY (Germany)

Author keywords

biology oriented synthesis; chemical biology; hedgehog pathway; natural products; total synthesis

Indexed keywords

BIOLOGY; ESTERS; FUNCTIONAL GROUPS; PLANTS (BOTANY); PROTEINS; SIGNAL TRANSDUCTION; STEREOSELECTIVITY;

BIOLOGICAL EVALUATION; CHEMICAL BIOLOGY; HEDGEHOG PATHWAY; HEDGEHOG SIGNALING PATHWAYS; NATURAL PRODUCTS; REACTIVE FUNCTIONAL GROUPS; STRUCTURAL INFORMATION; TOTAL SYNTHESIS;

CELL SIGNALING;

BIOLOGICAL PRODUCT; WITHANOLIDE;

ANIMAL; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; HEDGEHOG; METABOLISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BIOLOGICAL PRODUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEDGEHOGS; MOLECULAR CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; WITHANOLIDES;

EID: 84929462034 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201500112 Document Type: Article

Times cited : (56)

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