Association between venous thromboembolism and iron-deficiency anemia: A population-based study

Blood Coagulation and Fibrinolysis

Volumn 26, Issue 4, 2015, Pages 368-372

  Hung, Shih Han ^a   Lin, Herng Ching ^a   Chung, Shiu Dong ^a,b  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

Author keywords

anemia; iron deficiency anemia; venous thromboembolisms

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIABETES MELLITUS; DIAGNOSTIC TEST; DISEASE ASSOCIATION; FEMALE; FRACTURE; HEART FAILURE; HOSPITALIZATION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INCOME; IRON DEFICIENCY ANEMIA; ISCHEMIC HEART DISEASE; KIDNEY DISEASE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEOPLASM; PREVALENCE; PRIORITY JOURNAL; URBANIZATION; VENOUS THROMBOEMBOLISM; ANEMIA, IRON-DEFICIENCY; CASE CONTROL STUDY; COMPLICATION; ODDS RATIO; RISK FACTOR; STATISTICAL MODEL; TAIWAN; VENOUS THROMBOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; CASE-CONTROL STUDIES; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PREVALENCE; RISK FACTORS; TAIWAN; VENOUS THROMBOEMBOLISM; VENOUS THROMBOSIS;

EID: 84929458940     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0000000000000249     Document Type: Article

References (36)

1. Anderson FA Jr, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med 1991; 151:933-938.
2. Heit JA, O'FallonWM, Petterson TM, Lohse CM, Silverstein MD, Mohr DN, Melton LJ 3rd. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med 2002; 162:1245-1248.
3. Bagot CN, Arya R. Virchow and his triad: a question of attribution. Br J Haematol 2008; 143:180-190.
4. Martinelli I, Mannucci PM, De Stefano V, Taioli E, Rossi V, Crosti F, et al. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. Blood 1998; 92:2353-2358.
5. Koeleman BP, Reitsma PH, Bertina RM. Familial thrombophilia: a complex genetic disorder. Semin Hematol 1997; 34:256-264.
6. Mustafa S, Mannhalter C, Rintelen C, Kyrle PA, Knobl P, Lechner K, Pabinger I. Clinical features of thrombophilia in families with gene defects in protein C or protein S combined with factor V Leiden. Blood Coagul Fibrinolysis 1998; 9:85-89.
7. Fazel R, Froehlich JB, Williams DM, Saint S, Nallamothu BK. Clinical problem-solving. A sinister development-a 35-year-old woman presented to the emergency department with a 2-day history of progressive swelling and pain in her left leg, without antecedent trauma. N Engl J Med 2007; 357:53-59.
8. Hamoud S, Nitecky S, Engel A, Goldsher D, Hayek T. Hypoplasia of the inferior vena cava with azygous continuation presenting as recurrent leg deep vein thrombosis. Am J Med Sci 2000; 319:414-416.
9. Simioni P, Tormene D, Tognin G, Gavasso S, Bulato C, Iacobelli NP, et al. X-linked thrombophilia with a mutant factor IX (factor IX Padua). N Engl J Med 2009; 361:1671-1675.
10. Lawler PR, Filion KB, Dourian T, Atallah R, Garfinkle M, Eisenberg MJ. Anemia and mortality in acute coronary syndromes: a systematic review and meta-analysis. Am Heart J 2013; 165:143-153.
11. Vlagopoulos PT, Tighiouart H, Weiner DE, Griffith J, Pettitt D, Salem DN, et al. Anemia as a risk factor for cardiovascular disease and all-cause mortality in diabetes: the impact of chronic kidney disease. J Am Soc Nephrol 2005; 16:3403-3410.
12. Sabatine MS, Morrow DA, Giugliano RP, Burton PBJ, Murphy SA, McCabe CH, et al. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation 2005; 111:2042-2049.
13. Nikolsky E, Aymong ED, Halkin A, Grines CL, Cox DA, Garcia E, et al. Impact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary interventionAnalysis from the controlled abciximab and device investigation to lower late angioplasty complications (cadillac) trial. J Am Coll Cardiol 2004; 44:547-553.
14. Alexander MB. Iron deficiency anemia, thrombocytosis, and cerebrovascular accident. South Med J 1983; 76:662-663.
15. Belman AL, Roque CT, Ancona R, Anand AK, Davis RP. Cerebral venous thrombosis in a child with iron deficiency anemia and thrombocytosis. Stroke 1990; 21:488-493.
16. Stehle G, Buss J, Heene DL. Noninfectious thrombosis of the superior sagittal sinus in a patient with iron deficiency anemia. Stroke 1991; 22:414.
17. Saxena K, Ranalli M, Khan N, Blanchong C, Kahwash SB. Fatal stroke in a child with severe iron deficiency anemia and multiple hereditary risk factors for thrombosis. Clin Pediatr 2005; 44:175-180.
18. Stolz E, Valdueza JM, Grebe M, Schlachetzki F, Schmitt E,Madlener K, et al. Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited. Results of a prospective study. J Neurol 2007; 254:729-734.
19. Ogata T, Kamouchi M, Kitazono T, Kuroda J, Ooboshi H, Shono T, et al. Cerebral venous thrombosis associated with iron deficiency anemia. J Stroke Cerebrovasc Dis 2008; 17:426-428.
20. Huang PH, Su JJ, Lin PH. Iron deficiency anemia-a rare etiology of sinus thrombosis in adults. Acta Neurol Taiwan 2010; 19:125-130.
21. Ghosh PS, Plautz G, Cerejo R, Moodley M. Cerebral venous sinus thrombosis in a child with iron-deficiency anemia. Acta Neurol Belg 2014; 114:131-132.
22. Corrales-Medina FF, Grant L, Egas-Bejar D, Validivia-Ascuna Z, Rodrigues N, Mancias P. Cerebral sinovenous thrombosis associated with iron deficiency anemia secondary to severe menorrhagia: a case report. J Child Neurol 2014; 29:NP62-NP64.
23. Kang JH, Chen YH, Lin HC. Comorbidity profiles among patients with ankylosing spondylitis: a nationwide population-based study. Ann Rheum Dis 2010; 69:1165-1168.
24. Cheng CL, Kao YH, Lin SJ, Lee CH, Lai ML. Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan. Pharmacoepidemiol Drug Saf 2011; 20:236-242.
25. Sayer JM, Long RG. A perspective on iron deficiency anaemia. Gut 1993; 34:1297-1299.
26. Chang YL, Hung SH, Ling W, Lin HC, Chung SD. Association between ischemic stroke and iron-deficiency anemia: a population-based study. PLOS One 2013; 8:; e82952.
27. Yakushiji Y, Terasaki Y, Otsubo R, Yasaka M, Oe H, Yamada N, et al. Brain embolism caused by a mobile aortic thrombus with iron deficiency anemia. Cerebrovasc Dis 2005; 20:475-478.
28. Akins PT, Glenn S, Nemeth PM, Derdeyn CP. Carotid artery thrombus associated with severe iron-deficiency anemia and thrombocytosis. Stroke 1996; 27:1002-1005.
29. Yarnell P, Earnest M, Kelly G, Sanders B. Disappearing carotid defects. Stroke 1978; 9:258-262.
30. Ng KF, Lam CC, Chan LC. In vivo effect of haemodilution with saline on coagulation: a randomized controlled trial. Br J Anaesth 2002; 88:475-480.
31. Caliskan U, Oner AF, Kabakus N, Koc H. Diminished platelet aggregation in patients with iron deficiency anemia. Clin Appl Thromb Hemost 1999; 5:161-163.
32. Vaughan DE. PAI-1 and atherothrombosis. J Thromb Haemost 2005; 3:1879-1883.
33. Turpini R, Stefanini M. The nature and mechanism of the hemostatic breakdown in the course of experimental hemorrhagic shock. J Clin Invest 1959; 38:53-65.
34. Bukharovich IF, Wever-Pinzon O, Shah A, Todd G, Chaudhry FA, Sherrid MV. Arterial embolism caused by large mobile aortic thrombus in the absence of atherosclerosis, associated with iron deficiency anemia. Echocardiography 2012; 29:369-372.
35. Livesey JA, Manning RA, Meek JH, Jackson JE, Kulinskaya E, Laffan MA, Shovlin CL. Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia. Thorax 2012; 67:328-333.
36. Goddard AF, James MW, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anaemia. Gut 2011; 60:1309-1316.