Expression of human tissue factor pathway inhibitor on vascular smooth muscle cells inhibits secretion of macrophage migration inhibitory factor and attenuates atherosclerosis in ApoE-/- mice

Circulation

Volumn 131, Issue 15, 2015, Pages 1350-1360

  Chen, Daxin ^a   Xia, Min ^b   Hayford, Claudia ^a   Tham, El Li ^a   Semik, Vikki ^a   Hurst, Stuart ^a   Chen, Ying ^c   Tam, Henry H ^c   Pan, Jun ^d   Wang, Yucheng ^d   Tan, Xiaojin ^e   Lan, Hui Yao ^d   Shen, Huahao ^f   Kakkar, Vijay V ^b   Xu, Qingbo ^g   McVey, John H ^a,h   Dorling, Anthony ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e UNIVERSITY OF SOUTH CHINA   (China)

^f ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^g KING'S COLLEGE LONDON   (United Kingdom)

^h UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Anticoagulants; Atherosclerosis; Inflammation; Muscle; Smooth

Indexed keywords

APOLIPOPROTEIN E; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 9; D DIMER; GAMMA INTERFERON; MACROPHAGE MIGRATION INHIBITION FACTOR; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTHROMBIN; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; TISSUE FACTOR PATHWAY INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; LIPOPROTEIN; LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA SINUS; ARTICLE; ATHEROMA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BODY WEIGHT; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; LIPID DIET; LIPID METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DEFICIENCY; DISEASE MODEL; FEMALE; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; LEUKOCYTES; LIPID METABOLISM; LIPOPROTEINS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; SIGNAL TRANSDUCTION;

EID: 84929380224     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.013423     Document Type: Article

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