Detection of low-level mixed-population drug resistance in Mycobacterium tuberculosis using high fidelity amplicon sequencing

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Colman, Rebecca E ^a   Schupp, James M ^a   Hicks, Nathan D ^a   Smith, David E ^a   Buchhagen, Jordan L ^a   Valafar, Faramarz ^b   Crudu, Valeriu ^c   Romancenco, Elena ^d   Noroc, Ecaterina ^c   Jackson, Lynn ^d   Catanzaro, Donald G ^e   Rodwell, Timothy C ^d   Catanzaro, Antonino ^d   Keim, Paul ^a,f   Engelthaler, David M ^a  

^a TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

^c Microbiology and Morphology Laboratory   (Moldova)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF ARKANSAS   (United States)

^f NORTHERN ARIZONA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; TUBERCULOSTATIC AGENT;

AMPLICON; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM IDENTIFICATION; CONTROLLED STUDY; DNA SEQUENCE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE SEQUENCE; IN VITRO STUDY; MOLECULAR DYNAMICS; MYCOBACTERIUM TUBERCULOSIS; NEXT GENERATION SEQUENCING; NONHUMAN; PHENOTYPE; PROMOTER REGION; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS; GENE LOCUS; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR DIAGNOSIS; MULTIDRUG RESISTANCE; SINGLE NUCLEOTIDE POLYMORPHISM; SPUTUM; TUBERCULOSIS, MULTIDRUG-RESISTANT; TUBERCULOSIS, PULMONARY;

MYCOBACTERIUM TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENE FREQUENCY; GENETIC LOCI; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DIAGNOSTIC TECHNIQUES; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; SPUTUM; TUBERCULOSIS, MULTIDRUG-RESISTANT; TUBERCULOSIS, PULMONARY;

EID: 84929376752     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126626     Document Type: Article

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