Frequent epigenetic suppression of tumor suppressor gene glutathione peroxidase 3 by promoter hypermethylation and its clinical implication in clear cell renal cell carcinoma

International Journal of Molecular Sciences

Volumn 16, Issue 5, 2015, Pages 10636-10649

  Liu, Qianling ^a   Jin, Jie ^a   Ying, Jianming ^b   Sun, Mengkui ^a   Cui, Yun ^a   Zhang, Lian ^a   Xu, Ben ^a   Fan, Yu ^a   Zhang, Qian ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Clear cell renal cell carcinoma; GPX3; Methylation; Reactive oxygen species; Tumor suppress gene

Indexed keywords

BISULFITE; DECITABINE; GLUTATHIONE PEROXIDASE 3; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; GLUTATHIONE PEROXIDASE; GPX3 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER PROGNOSIS; CELL CULTURE; CONTROLLED STUDY; DEMETHYLATION; DNA DAMAGE; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; FEMALE; GENE REPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; KIDNEY PARENCHYMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RENAL CELL CARCINOMA CELL LINE; TUMOR SUPPRESSOR GENE; AGED; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HEK293 CELL LINE; KIDNEY TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

AGED; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELLS, CULTURED; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GLUTATHIONE PEROXIDASE; HEK293 CELLS; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC;

EID: 84929310959     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160510636     Document Type: Article

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