Shedding of norovirus in symptomatic and asymptomatic infections

Epidemiology and Infection

Volumn 143, Issue 8, 2015, Pages 1710-1717

  Teunis, P F M ^a,b   Sukhrie, F H A ^a,c   Vennema, H ^a   Bogerman, J ^c,d   Beersma, M F C ^c   Koopmans, M P G ^c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b EMORY UNIVERSITY   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d Public Health Service of the Rotterdam Region   (Netherlands)

Author keywords

Asymptomatic viral infections; gastrointestinal infections; Norwalk agent and related viruses; virology (human) and epidemiology; virus infection

Indexed keywords

ADULT; AGED; ARTICLE; ASYMPTOMATIC INFECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SURVEILLANCE; EPIDEMIC; FECES ANALYSIS; HUMAN; NOROVIRUS; NOROVIRUS INFECTION; REAL TIME POLYMERASE CHAIN REACTION; VIRUS SHEDDING; VIRUS TRANSMISSION;

EID: 84929290121     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S095026881400274X     Document Type: Article

References (31)

1. Friesema I, et al. Norovirus outbreaks in nursing homes: the evaluation of infection control measures. Epidemiology and Infection 2009; 137: 1722-1733.
2. Lopman BA, et al. Increasing rates of gastroenteritis hospital discharges in US adults and the contribution of norovirus, 1996-2007. Clinical Infectious Diseases 2011; 52: 466-474.
3. Koopmans M. Progress in understanding norovirus epidemiology. Current Opinion in Infectious Diseases 2008; 21: 544-552.
4. Heijne JCM, et al. Enhanced hygiene measures and norovirus transmission during an outbreak. Emerging Infectious Diseases 2009; 15: 24-30.
5. Teunis PF, et al. Norwalk virus: how infectious is it?Journal of Medical Virology 2008; 80: 1468-1476.
6. Atmar RL, et al. Norovirus vaccine against experimental human Norwalk Virus illness. New England Journal of Medicine 2011; 365: 2178-2187.
7. Becker KM, et al. Transmission of Norwalk virus during a football game. New England Journal of Medicine 2000; 343: 1223-1227.
8. Evans MR, et al. An outbreak of viral gastroenteritis following environmental contamination at a concert hall. Epidemiology and Infection 2002; 129: 355-360.
9. Boxman I, et al. Norovirus on swabs taken from hands illustrate route of transmission: a case study. Journal of Food Protection 2009; 72: 1753-1755.
10. Boone SA, Gerba CP. Significance of fomites in the spread of respiratory and enteric viral disease. Applied and Environmental Microbiology 2007; 73: 1687-1696.
11. Atmar RL, et al. Norwalk virus shedding after experimental human infection. Emerging Infectious Diseases 2008; 14: 1553-1557.
12. Kirby AE, et al. Disease course and viral shedding in experimental Norwalk virus and Snow Mountain virus infection. Journal of Medical Virology. Published online: 14 February 2014. doi:10.1002/jmv.23905.
13. Graham DY, et al . Norwalk virus infection of volunteers: new insights based on improved assays. Journal of Infectious Diseases 1994; 170: 34-43.
14. Verhoef L, et al. Use of norovirus genotype profiles to differentiate origins of foodborne outbreaks. Emerging Infectious Diseases 2010; 16: 617-624.
15. Matthews JE, et al. The epidemiology of published norovirus outbreaks: a review of risk factors associated with attack rate and genogroup. Epidemiology and Infection 2012; 140: 1161-1172.
16. Sukhrie FHA, et al. Chronic shedders as reservoir for nosocomial transmission of norovirus. Journal of Clinical Microbiology 2010; 48: 4303-4305.
17. Sukhrie FHA, et al. Nosocomial transmission of norovirus is mainly caused by symptomatic cases. Clinical Infectious Diseases 2012; 54: 931-937.
18. Sukhrie FHA, et al. Using molecular epidemiology to trace transmission of nosocomial norovirus infection. Journal of Clinical Microbiology 2011; 49 : 602-606.
19. Teunis PFM, Ogden ID, Strachan NJC. Hierarchical dose response of E. coli O157: H7 from human outbreaks incorporating heterogeneity in exposure. Epidemiology and Infection 2008; 136: 761-770.
20. rd International Workshop on Distributed Statistical Computing (DSC 2003). Vienna, Austria, 2003, pp. 1-10.
21. Plummer M. rjags: Bayesian graphical models using MCMC, 2013 (http://CRAN.R-project.org/package=rjags). R package version 3-10.
22. R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria, 2013 (http://www.Rproject.org/).
23. Aoki Y, et al. Duration of norovirus excretion and the longitudinal course of viral load in norovirus-infected elderly patients. Journal of Hospital Infection 2010; 75: 42-46.
24. Lee N, et al. Fecal viral concentration and diarrhea in norovirus gastroenteritis. Emerging Infectious Diseases 2007; 13: 1399-1401.
25. Marks PJ, et al. Evidence for airborne transmission of Norwalk-like virus in a hotel restaurant. Epidemiology and Infection 2000; 124: 481-487.
26. Kirby A, et al. Detection of norovirus in mouthwash samples from patients with acute gastroenteritis. Journal of Clinical Virology 2010; 48: 285-287.
27. Blacklow NR, et al. Epidemiology of adenovirus-associated virus infection in a nursery population. American Journal of Epidemiology 1968; 88: 368-378.
28. Polish LB, et al. Excretion of hepatitis A virus (HAV) in adults: comparison of immunologic and molecular detection methods and relationship between HAV positivity and infectivity in tamarins. Journal of Clinical Microbiology 1999; 37: 3615-3617.
29. de Roda Husman A, et al. A long-term inactivation study of three enteroviruses in artifi cial surface water and ground water by PCR and cell culture. Applied and Environmental Microbiology 2009; 75:1050-1057.
30. Heijne JCM, et al. Quantifying transmission of norovirus during an outbreak. Epidemiology 2012; 23: 277-284.
31. Teunis P, et al. Infectious disease transmission as a forensic problem: who infected whom? Journal of the Royal Society Interface 2013; 10: 20120955-20120955.