Peripheral blood eosinophilia and hypersensitivity reactions among patients receiving outpatient parenteral antibiotics

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 5, 2015, Pages 1288-1294.e1

  Blumenthal, Kimberly G ^a,b   Youngster, Ilan ^a,b,c   Rabideau, Dustin J ^a   Parker, Robert A ^a,b   Manning, Karen S ^a   Walensky, Rochelle P ^a,b   Nelson, Sandra B ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Allergy; antibiotic; drug; drug rash with eosinophilia and systemic symptoms syndrome; eosinophilia; hypersensitivity; metronidazole; outpatient parenteral antimicrobial therapy; vancomycin

Indexed keywords

AMINOGLYCOSIDE; AMPHOTERICIN B; ANTIBIOTIC AGENT; AZTREONAM; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; DAPTOMYCIN; FLUCONAZOLE; LINEZOLID; MACROLIDE; METRONIDAZOLE; PENICILLIN DERIVATIVE; QUINOLONE DERIVATIVE; RIFAMPICIN; TETRACYCLINE DERIVATIVE; VANCOMYCIN; VORICONAZOLE; ALLERGEN; ANTIINFECTIVE AGENT;

ADULT; AGED; ALLERGIC REACTION; ANTIBIOTIC THERAPY; ARTICLE; BLOOD CELL COUNT; COHORT ANALYSIS; DEMOGRAPHY; DRESS SYNDROME; DRUG EXPOSURE; DRUG USE; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; HOSPITAL PATIENT; HUMAN; KIDNEY INJURY; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; OUTPATIENT; PATIENT MONITORING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RASH; RISK FACTOR; TREATMENT DURATION; AMBULATORY CARE; CIRCULATION; DRUG HYPERSENSITIVITY SYNDROME; EOSINOPHIL; IMMUNOLOGY; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL;

ALLERGENS; AMBULATORY CARE; ANTI-BACTERIAL AGENTS; BLOOD CIRCULATION; COHORT STUDIES; DRUG HYPERSENSITIVITY SYNDROME; EOSINOPHILS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES;

EID: 84929179266     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.04.005     Document Type: Article

References (41)

1. Nutman, T.B., Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am 27 (2007), 529–549.
2. Roufosse, F., Weller, P.F., Practical approach to the patient with hypereosinophilia. J Allergy Clin Immunol 126 (2010), 39–44.
3. Weller P. Approach to the patient with eosinophilia. In: Basow DS, editor. Waltham (MA): UpToDate; 2013.
4. Baker, R.J., Pusey, C.D., The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transplant 19 (2004), 8–11.
5. Baldwin, D.S., Levine, B.B., McCluskey, R.T., Gallo, G.R., Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med 279 (1968), 1245–1252.
6. Bircher AJ. Exanthematous (morbilliform) drug eruption. In: Basow DS, editor. Waltham (MA): UpToDate; 2013.
7. Bocquet, H., Bagot, M., Roujeau, J.C., Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). Semin Cutan Med Surg 15 (1996), 250–257.
8. Bouvresse, S., Valeyrie-Allanore, L., Ortonne, N., Konstantinou, M.P., Kardaun, S.H., Bagot, M., et al. Toxic epidermal necrolysis, DRESS, AGEP: do overlap cases exist?. Orphanet J Rare Dis, 7, 2012, 72.
9. Solensky, R., Khan, D., Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol 105 (2010), 259–273.
10. Cacoub, P., Musette, P., Descamps, V., Meyer, O., Speirs, C., Finzi, L., et al. The DRESS syndrome: a literature review. Am J Med 124 (2011), 588–597.
11. Yang, J., Yang, X., Li, M., Peripheral blood eosinophil counts predict the prognosis of drug eruptions. J Investig Allergol Clin Immunol 23 (2013), 248–255.
12. Macy, E., Ho, N.J., Multiple drug intolerance syndrome: Prevalence, clinical characteristics and management. Ann Allergy Asthma Immunol 108 (2012), 88–93.
13. Macy, E., Poon, K.-Y.T., Self-reported antibiotic allergy incidence and prevalence: age and sex effects. Am J Med 122 (2009), 778.e1–778.e7.
14. Mittal, N., Gupta, M., Singla, M., Cutaneous adverse drug reactions notified by pharmacovigilance in a tertiary care hospital in north India. Cutan Ocul Toxicol 33 (2014), 289–293.
15. Nandha, R., Gupta, A., Hashmi, A., Cutaneous adverse drug reactions in a tertiary care teaching hospital: a north Indian perspective. Int J Appl Basic Med Res 1 (2011), 50–53.
16. Fridkin, S., Baggs, J., Fagan, R., Shelley, M., Pollack, L.A., Malpiedi, P., et al. Vital signs: Improving antibiotic use among hospitalized patients. MMWR Morb Mortal Wkly Rep 63 (2014), 194–200.
17. Tunkel, A.R., Hartman, B.J., Kaplan, S.L., Kaufman, B.A., Roos, K.L., Scheld, M., et al. Practical guidelines for the management of bacterial meningitis. Clin Infect Dis 39 (2004), 1267–1284.
18. Osmon, D.R., Berbari, E.F., Berendt, A.R., Lew, D., Zimmerli, W., Stechelberg, J.M., et al. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Disease Society of America. Clin Infect Dis 56 (2012), e1–e25.
19. Baddour, L.M., Wilson, W.R., Bayer, A.S., Fowler, V.G., Bolger, A.F., Levison, M.E., et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for health care professionals from the committee on rheumatic fever, endocarditis and Kawasaki disease, Council on Cardiovascular Disease in the Young, and Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: Endorsed by the Infectious Disease Society of America. Circulation 111 (2005), e394–e434.
20. Tice, A.D., Rehm, S.J., Dalovisio, J.R., Bradley, J.S., Martinelli, L.P., Graham, D.R., et al. Practice guidelines for outpatient parenteral antimicrobial therapy. Clin Infect Dis 38 (2004), 1651–1672.
21. Mejia, R., Nutman, T.B., Evaluation and differential diagnosis of marked, persistent eosinophilia. Semin Hematol 49 (2012), 149–159.
22. Blumenthal, K.G., Patil, S., Long, A.A., The importance of vancomycin in drug rash eosinophilia and systemic symptoms (DRESS) syndrome. Allergy Asthma Proc 33 (2012), 165–171.
23. Jeung, J., Lee, J.Y., Oh, M.J., Choi, D.C., Lee, B.J., Comparison of the causes and clinical features of drug rash with eosinophilia and systemic symptoms and Stevens-Johnson syndrome. Allergy Asthma Immunol Res 2 (2010), 123–126.
24. Youngster, I., Shenoy, E.S., Hooper, D.C., Nelson, S.B., Comparative evaluation of the tolerability of cefazolin and nafcillin for treatment of methicillin-susceptible Staphylococcus aureus infections in the outpatient setting. Clin Infect Dis 59 (2014), 369–375.
25. Kardaun, S.H., Sidoroff, A., Valeyrie-Allanore, L., Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?. Br J Dermatol 156 (2007), 609–611.
26. Chaiken, B.H., Goldberg, B.I., Segal, J.P., Dilantin sensitivity. N Engl J Med 242 (1950), 897–898.
27. An, S.Y., Hwang, E.K., Kim, J.E., Jin, H.J., Kyun, J.O., Lee, Y.H., et al. Vancomycin-associated spontaneous cutaneous adverse drug reactions. Allergy Asthma Immunol Res 3 (2011), 194–198.
28. Verma, C.R., Vasudevan, B., Pragasam, V., Severe cutaneous adverse drug reactions. Med J Armed Forces India 69 (2013), 375–383.
29. Lin, Y., Yang, C., Sindy, H., Lin, J., Hui, C.R., Tsai, Y., et al. Severe cutaneous adverse reactions related to systemic antibiotics. Clin Infect Dis 58 (2014), 1377–1385.
30. Venning, V.A., Linear IgA disease: clinical presentation, diagnosis, and pathogenesis. Dermatol Clin 29 (2011), 453–458.
31. Marik, P.E., Ferris, N., Delayed hypersensitivity to vancomycin. Pharmacotherapy 17 (1997), 1341–1344.
32. Blumenthal, K.G., Wickner, P.G., Lau, J.J., Zhou, L., Stevens-Johnson syndrome and toxic epidermal necrolysis: a cross-sectional analysis of patients in an integrated allergy repository of a large health care system. J Allergy Clin Immunol Pract 3 (2015), 277–280.e1.
33. World Health Organization. Antimicrobial resistance: global report on surveillance. 2014, WHO Press, Geneva, Switzerland Available at: http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf Accessed January 3, 2015.
34. Vauthey, L., Uckay, I., Abrassart, S., Vauthey, L., Uckay, I., Abrassart, S., et al. Vancomycin-induced DRESS syndrome in a female patient, et al. Vancomycin-induced DRESS syndrome in a female patient. Pharmacology 82 (2008), 138–141.
35. O'Meara, P., Borici-Mazi, R., Morton, A.R., Ellis, A.K., DRESS with delayed onset acute interstitial nephritis and profound refractory eosinophilia secondary to Vancomycin. Allergy Asthma Clin Immunol, 7, 2011, 16.
36. Zuliani, E., Zwahlen, H., Gilliet, F., Marone, C., Vancomycin-induced hypersensitivity reaction with acute renal failure: resolution following cyclosporine treatment. Clin Nephrol 64 (2005), 155–158.
37. Kodner, C.M., Kudrimoti, A., Diagnosis and management of acute insterstitial nephritis. Am Fam Physician 67 (2003), 2527–2534.
38. Roujeau, J.C., Clinical heterogeneity of drug hypersensitivity. Toxicology 209 (2005), 123–129.
39. Terradas, R., Grau, S., Blanch, J., Riu, M., Saballs, P., Castells, X., et al. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One, 7, 2012, e42860.
40. Wibrow, B.A., Ho, K.M., Flexman, J.P., Keil, A.D., Kohrs, D.L., Eosinopenia as a diagnostic marker for bloodstream infection in hospitalised paediatric and adult patients: a case-control study. Anaesth Intensive Care 39 (2011), 224–230.
41. Abidi, K., Khoudri, I., Belayachi, H., Madani, N., Zekraoui, A., Zeggwagh, A.A., et al. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care, 12, 2008, R59.