Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters

Journal of Toxicological Sciences

Volumn 40, Issue 3, 2015, Pages 339-348

  Kurokawa, Junko ^a   Sasano, Tetsuo ^a   Kodama, Masami ^a   Li, Min ^a   Ebana, Yusuke ^a   Harada, Nobuhiro ^c   Honda, Shin Ichiro ^c   Nakaya, Haruaki ^b   Furukawa, Tetsushi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiac electrophysiology; Cardiac toxicology; ECG; Estrogen; HERG channel

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; TRANSCRIPTION FACTOR ERG; 1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; AROMATASE; ERG1 POTASSIUM CHANNEL; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; ELECTROCARDIOGRAPHY; FEMALE; HEART ELECTROPHYSIOLOGY; HEART RATE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; QRS COMPLEX; QT INTERVAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; PHYSIOLOGY;

CAVIA; MURINAE; MUS;

ANIMALS; AROMATASE; ELECTROCARDIOGRAPHY; ESTROGENS; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HEART RATE; MICE, INBRED C57BL; MICE, KNOCKOUT; PIPERIDINES; PYRIDINES;

EID: 84929174266     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.40.339     Document Type: Article

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