Monocyte dysfunction as a previously unrecognized pathophysiological mechanism in ApoE-/-mice contributing to impaired arteriogenesis

International Journal of Cardiology

Volumn 190, Issue 1, 2015, Pages 214-216

  Tchaikovski, V ^a,b   Tchaikovski, S ^a,e   Olieslagers, S ^a   Waltenberger, J ^a,c,d  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Arteriogenesis; Atherosclerosis; Cell function; Growth factors; Hyperlipidemia; Monocytes

Indexed keywords

CD11B ANTIGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; TRIACYLGLYCEROL; VASCULOTROPIN A; APOLIPOPROTEIN E;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL COUNT; CELL MIGRATION; CELL MOTILITY; CHEMOTAXIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; LETTER; LEUKOCYTE DISORDER; MONOCYTE DYSFUNCTION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; CELL MOTION; DEFICIENCY; FEMALE; KNOCKOUT MOUSE; MALE; METABOLISM; MONOCYTE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL MOVEMENT; CHEMOTAXIS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES;

EID: 84929156927     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2015.04.188     Document Type: Article

References (14)

1. D. Tirziu, K.L. Moodie, Z.W. Zhuang, K. Singer, A. Helisch, J.F. Dunn, et al, Delayed arteriogenesis in hypercholesterolemic mice, Circulation 112 (2005) 2501-2509.
2. W. Schaper, Collateral circulation: past and present, Basic Res. Cardiol. 104 (2009) 5-21.
3. V. Tchaikovski, G. Fellbrich, J. Waltenberger, The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes, Arterioscler. Thromb. Vasc. Biol. 28 (2008) 322-328.
4. J. Waltenberger, Stress testing at the cellular and molecular level to unravel cellular dysfunction and growth factor signal transduction defects: what Molecular Cell Biology can learn from Cardiology, Thromb. Haemost. 98 (2007) 975-979.
5. V. Tchaikovski, S. Olieslagers, F.D. Bohmer, J. Waltenberger, Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes, Circulation 120 (2009) 150-159.
6. S.N. Tchaikovski, B.J. van Vlijmen, J. Rosing, G. Tans, Development of a calibrated automated thrombography based thrombin generation test in mouse plasma, J. Thromb. Haemost. 5 (2007) 2079-2086.
7. M. Kerber, Y. Reiss, A. Wickersheim, M. Jugold, F. Kiessling, M. Heil, et al., Flt-1 signaling in macrophages promotes glioma growth in vivo, Cancer Res. 68 (2008) 7342-7351.
8. G.K. Hansson, A. Hermansson, The immune system in atherosclerosis, Nat. Immunol. 12 (2011) 204-212.
9. N. van Royen, I. Hoefer, I. Buschmann, S. Kostin, M. Voskuil, C. Bode, et al., Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits, Cardiovasc. Res. 57 (2003) 178-185.
10. T. Terry, Z. Chen, R.A. Dixon, P. Vanderslice, P. Zoldhelyi, J.T. Willerson, et al, CD34/M-cadherin bone marrow progenitor cells promote arteriogenesis in ischemic hindlimbs of ApoE mice, PLoS One 6 (2011) e20673.
11. I. Tabas, The role of endoplasmic reticulum stress in the progression of atherosclerosis, Circ. Res. 107 (2010) 839-850.
12. F.K. Swirski, M. Nahrendorf, Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure, Science 339 (2013) 161-166.
13. P. Dutta, G. Courties, Y. Wei, F. Leuschner, R. Gorbatov, C.S. Robbins, et al., Myocardial infarction accelerates atherosclerosis, Nature 487 (2012) 325-329.
14. V. van Weel, M. de Vries, P.J. Voshol, R.E. Verloop, P.H. Eilers, V.W. van Hinsbergh, et al., Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice, Arterioscler. Thromb. Vasc. Biol. 26 (2006) 1383-1390.