Brentuximab vedotin for relapsed or refractory Hodgkin’s lymphoma

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 1729-1733

  Chen, Runzhe ^a   Chen, Baoan ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

Antitumor effects; CD30 positive; Clinical trials; Lymphoma; Monoclonal antibody; Tumor cells

Indexed keywords

BRENTUXIMAB VEDOTIN; CD30 ANTIGEN; TUMOR NECROSIS FACTOR; ANTIBODY CONJUGATE;

ANTINEOPLASTIC ACTIVITY; ARTHRALGIA; B CELL LYMPHOMA; CYTOMEGALOVIRUS INFECTION; DIARRHEA; DRUG DOSE ESCALATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; FATIGUE; FEVER; HODGKIN DISEASE; HUMAN; HYPERGLYCEMIA; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; NONHODGKIN LYMPHOMA; NONHUMAN; PERIPHERAL NEUROPATHY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROGRESSION FREE SURVIVAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; PROTEIN EXPRESSION; PROTEIN TARGETING; REFRACTORY HODGKIN DISEASE; RELAPSED HODGKIN DISEASE; REVIEW; SENSORY NEUROPATHY; STEVENS JOHNSON SYNDROME; T CELL LYMPHOMA; THROMBOCYTOPENIA; TREATMENT RESPONSE; TUMOR LYSIS SYNDROME; CLINICAL TRIAL (TOPIC); PATHOLOGY; RECURRENT DISEASE;

CLINICAL TRIALS AS TOPIC; HODGKIN DISEASE; HUMANS; IMMUNOCONJUGATES; RECURRENCE;

EID: 84929156508     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S82007     Document Type: Review

References (41)

1. Younes A. Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma. Hematology. 2009:507–519.
2. Eichenauer DA, Boll B, Diehl V. Pharmacotherapy of Hodgkin lymphoma: standard approaches and future perspectives. Expert Opin Pharmacother. 2014;15(8):1139–1151.
3. Zinzani PL, Viviani S, Anastasia A, et al. Brentuximab vedotin in relapsed/refractory Hodgkin’s lymphoma: the Italian experience and results of its use in daily clinical practice outside clinical trials. Haematologica. 2013;98(8):1232–1236.
4. Dinner S, Advani R. Targeted therapy in relapsed classical Hodgkin lymphoma. J Natl Compr Canc Netw. 2013;11(8):968–976.
5. Garciaz S, Coso D, Peyrade F, et al. Brentuximab vedotin followed by allogeneic transplantation as salvage regimen in patients with relapsed and/or refractory Hodgkin’s lymphoma. Hematol Oncol. 2014;32(4):187–189. doi:10.1002/hon.2119.
6. Ogura M, Tobinai K, Hatake K, et al. Phase I/II study of brentuximab vedotin in Japanese patients with relapsed or refractory CD30-positive Hodgkin’s lymphoma or systemic anaplastic large-cell lymphoma. Cancer Sci. 2014;105(7):840–846.
7. Younes A. Brentuximab vedotin for the treatment of patients with Hodgkin lymphoma. Hematol Oncol Clin North Am. 2014;28(1):27–32.
8. Deng C, Pan B, O’Connor OA. Brentuximab vedotin. Clin Cancer Res. 2013;19(1):22–27.
9. Devita MD, Evens AM, Rosen ST, Greenberger PA, Petrich AM. Multiple successful desensitizations to brentuximab vedotin: a case report and literature review. J Natl Compr Canc Netw. 2014;12(4):465–471.
10. Rothe A, Sasse S, Goergen H, et al. Brentuximab vedotin for relapsed or refractory CD30+ hematologic malignancies: the German Hodgkin Study Group experience. Blood. 2012;120(7):1470–1472.
11. Macalalad AR, McAuliffe M, Yang H, et al. The epidemiology and targeted therapies for relapsed and refractory CD30+ lymphomas. Curr Med Res Opin. 2015:1–32. Epub February 9, 2015.
12. Kharfan-Dabaja MA, Hamadani M, Sibai H, Savani BN. Managing Hodgkin lymphoma relapsing after autologous hematopoietic cell transplantation: a not-so-good cancer after all! Bone Marrow Transplant. 2014;49(5):599–606.
13. Gopal AK, Bartlett NL, Forero-Torres A, et al. Brentuximab vedotin in patients aged 60 years or older with relapsed or refractory CD30-positive lymphomas: a retrospective evaluation of safety and efficacy. Leuk Lymphoma. 2014;55(10):2328–2334.
14. Chihara D, Oki Y. Brentuximab vedotin for treatment of systemic T-cell lymphoma. Expert Opin Biol Ther. 2014;14(10):1519–1526.
15. Bradley AM, Devine M, DeRemer D. Brentuximab vedotin: an anti-CD30 antibody-drug conjugate. Am J Health Syst Pharm. 2013;70(7):589–597.
16. Hu S, Xu-Monette ZY, Balasubramanyam A, et al. CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study. Blood. 2013;121(14):2715–2724.
17. Pro B, Perini GF. Brentuximab vedotin in Hodgkin’s lymphoma. Expert Opin Biol Ther. 2012;12(10):1415–1421.
18. Deutsch YE, Tadmor T, Podack ER, Rosenblatt JD. CD30: an important new target in hematologic malignancies. Leuk Lymphoma. 2011;52(9):1641–1654.
19. Tsang V. Brentuximab vedotin in hodgkin lymphoma and anaplastic large cell lymphoma. J Adv Pract Oncol. 2012;3(3):184–190.
20. Bhatt S, Ashlock BM, Natkunam Y, et al. CD30 targeting with brentuximab vedotin: a novel therapeutic approach to primary effusion lymphoma. Blood. 2013;122(7):1233–1242.
21. Kumar A, Younes A. Role of CD30 targeting in malignant lymphoma. Curr Treat Options Oncol. 2014;15(2):210–225.
22. Diefenbach CS, Leonard JP. Targeting CD30 in Hodgkin lymphoma: antibody-drug conjugates make a difference. Am Soc Clin Oncol Educ Book. 2012:162–166.
23. Magge RS, DeAngelis LM. The double-edged sword: neurotoxicity of chemotherapy. Blood Rev. Epub December 3, 2014. doi:10.1016/j.blre.2014.09.012.
24. Gualberto A. Brentuximab vedotin (SGN-35), an antibody-drug conjugate for the treatment of CD30-positive malignancies. Expert Opin Investig Drugs. 2012;21(2):205–216.
25. Vaklavas C, Forero-Torres A. Safety and efficacy of brentuximab vedotin in patients with Hodgkin lymphoma or systemic anaplastic large cell lymphoma. Ther Adv Hematol. 2012;3(4):209–225.
26. Ansell SM. Brentuximab vedotin. Blood. 2014;124(22):3197–3200.
27. Nagai H. Recent advances in Hodgkin lymphoma: interim PET and molecular-targeted therapy. Jpn J Clin Oncol. Epub December 10, 2014. doi:10.1093/jjco/hyu204.
28. Minich SS. Brentuximab vedotin: a new age in the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma. Ann Pharmacother. 2012;46(3):377–383.
29. Younes A, Bartlett NL, Leonard JP, et al. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med. 2010;363(19):1812–1821.
30. Fanale MA, Forero-Torres A, Rosenblatt JD, et al. A phase I weekly dosing study of brentuximab vedotin in patients with relapsed/refractory CD30-positive hematologic malignancies. Clin Cancer Res. 2012;18(1):248–255.
31. Gopal AK, Ramchandren R, O’Connor OA, et al. Safety and efficacy of brentuximab vedotin for Hodgkin lymphoma recurring after allogeneic stem cell transplantation. Blood. 2012;120(3):560–568.
32. Younes A, Gopal AK, Smith SE, et al. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin’s lymphoma. J Clin Oncol. 2012;30(18):2183–2189.
33. Gopal AK, Chen R, Smith SE, et al. Durable remissions in a pivotal phase 2 study of brentuximab vedotin in relapsed or refractory Hodgkin lymphoma. Blood. Epub December 24, 2014. doi:10.1182/blood-2014-08-595801.
34. Pro B, Advani R, Brice P, et al. Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: results of a phase II study. J Clin Oncol. 2012;30(18):2190–2196.
35. Horwitz SM, Advani RH, Bartlett NL, et al. Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin. Blood. 2014;123(20):3095–3100.
36. Jacobsen ED, Sharman JP, Oki Y, et al. Brentuximab vedotin demonstrates objective responses in a phase 2 study of relapsed/refractory DLBCL with variable CD30 expression. Blood. Epub January 13, 2015. doi:10.1182/blood-2014-09-598763.
37. Forero-Torres A, Fanale M, Advani R, Bartlett NL, et al. Brentuximab vedotin in transplant-naive patients with relapsed or refractory Hodgkin lymphoma: analysis of two phase I studies. Oncologist. 2012;17(8):1073–1080.
38. Newland AM, Li JX, Wasco LE, Aziz MT, Lowe DK. Brentuximab vedotin: a CD30-directed antibody-cytotoxic drug conjugate. Pharmacotherapy. 2013;33(1):93–104.
39. Lai CM, Horowitz S. Brentuximab vedotin: treatment role for relapsed refractory systemic anaplastic large-cell lymphoma. Expert Rev Hematol. 2013;6(4):361–373.
40. Yang QM, Hong JY, Ko YH, et al. Brentuximab vedotin for relapsed or refractory CD30+ Hodgkin lymphoma: a multicenter analysis from Asia. Onco Targets Ther. 2014;7:1717–1722.
41. Thyss A, Saada E, Gastaud L, Peyrade F, Re D. Hodgkin’s lymphoma in older patients: an orphan disease? Mediterr J Hematol Infect Dis. 2014;6(1):e2014050.