Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus

Nutrition Journal

Volumn 14, Issue 1, 2015, Pages

  Yin, Raynold V ^a   Phung, Olivia J ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Chromium; Diabetes mellitus; Fasting plasma glucose; Glycated hemoglobin; Meta analysis; Systematic review

Indexed keywords

CHROMIUM; CHROMIUM CHLORIDE; CHROMIUM PICOLINATE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; CHLORIDE; CHROMIUM DERIVATIVE; GLUCOSE BLOOD LEVEL; PICOLINIC ACID; PICOLINIC ACID DERIVATIVE; TRACE ELEMENT;

ARTICLE; CHROMIUM YEAST; DIET RESTRICTION; GLUCOSE BLOOD LEVEL; HUMAN; LIMIT OF QUANTITATION; META ANALYSIS; MINERAL SUPPLEMENTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); SACCHAROMYCES CEREVISIAE; SYSTEMATIC REVIEW; THERAPY EFFECT; YEAST; ADULT; AGED; BLOOD; CHEMISTRY; DIET THERAPY; DIETARY SUPPLEMENT; DRUG EFFECTS; FEMALE; MALE; MIDDLE AGED; TREATMENT OUTCOME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; CHLORIDES; CHROMIUM; CHROMIUM COMPOUNDS; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; FASTING; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; PICOLINIC ACIDS; SACCHAROMYCES CEREVISIAE; TRACE ELEMENTS; TREATMENT OUTCOME;

EID: 84929149491     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-14-14     Document Type: Article

References (30)

1. Yeghiazaryan K, Schild HH, Golubnitschaja O: Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics. Infect Disord Drug Targets 2012,12(5):332-9. 10.2174/187152612804142215
2. Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-53. 10.2337/diacare.27.5.1047
3. Hakobyan L, Haaijer-Ruskamp FM, de Zeeuw D, Dobre D, Denig P: A review of methods used in assessing non-serious adverse drug events in observational studies among type 2 diabetes mellitus patients. Health Qual Life Outcomes 2011, 9:83. doi:10.1186/1477-7525-9-83 10.1186/1477-7525-9-83
4. Yeh GY, Eisenberg DM, Davis RB, Phillips RS: Use of complementary and alternative medicine among persons with diabetes mellitus: results of a national survey. Am J Public Health 2002,92(10):48-52.
5. Egede LE, Ye X, Zheng D, Silverstein MD: The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes. Diabetes Care 2002,25(2):324-9. 10.2337/diacare.25.2.324
6. Nutrition Business Journal: NBJ's Supplement Business Report 2003. San Diego, CA: Penton Media Inc; 2003.
7. Rabinovitz H, Friedensohn A, Leibovitz A, Gabay G, Rocas C, Habot B: Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004,74(3):178-82. 10.1024/0300-9831.74.3.178
8. National Institute of Health: Office of Dietary Supplements: Chromium: Dietary supplement fact sheet. 2013. [ONLINE] Available at:. [Accessed 09 February 15] http://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
9. Vincent JB: Elucidating a biological role for chromium at a molecular level. Acc Chem Res 2000,33(7):503-10. 10.1021/ar990073r
10. Lee NA, Reasner CA: Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care 1994,17(12):1449-52. 10.2337/diacare.17.12.1449
11. DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986,7(3):177-88. 10.1016/0197-2456(86)90046-2
12. Higgins JP, Altman DG, Gøtzsche PC, Juni P, Moher D, Oxman AD, et al.: Cochrane Bias Methods Group; Cochrane Statistical Methods Group. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011, 343:d5928. 10.1136/bmj.d5928
13. Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ 1997,315(7109):629-34. 10.1136/bmj.315.7109.629
14. Wallach S: Clinical and biochemical aspects of chromium deficiency. J Am College Nutr. 1985, 4:107-20. 10.1080/07315724.1985.10720070
15. Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V: Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Med Biol 2011,25(3):149-53. doi:10.1016/j.jtemb.2011.03.003. Epub 2011 May 12 10.1016/j.jtemb.2011.03.003
16. Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, et al.: Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997,46(11):1786-91. 10.2337/diab.46.11.1786
17. Abraham AS, Brooks BA, Eylath U: The effects of chromium supplementation on serum glucose and lipids in patients with and without non-insulin-dependent diabetes. Metabolism 1992,41(7):768-71. 10.1016/0026-0495(92)90318-5
18. Bahijiri SM, Mira SA, Mufti AM, Ajabnoor MA: The effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetes. Saudi Med J 2000,21(9):831-7.
19. Bahijri SM, Mufti AM: Beneficial effects of chromium in people with type 2 diabetes, and urinary chromium response to glucose load as a possible indicator of status. Biol Trace Elem Res 2002,85(2):97-109. 10.1385/BTER:85:2:097
20. Chen YL, Lin JD, Hsia TL, Mao FC, Hsu CH, Pei D: The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes. Eur J Nutr 2014,53(1):127-33. 10.1007/s00394-013-0508-8
21. Ghosh D, Bhattacharya B, Mukherjee B, Manna B, Sinha M, Chowdhury J, et al.: Role of chromium supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem 2002,13(11):690-7. 10.1016/S0955-2863(02)00220-6
22. Hunt AE, Allen KGD, Smith BA: Effect of chromium supplementation on hair chromium concentration and diabetic status. Nutr Res 1985,5(2):131-40. 10.1016/S0271-5317(85)80028-2
23. Jain SK, Kahlon G, Morehead L, Dhawan R, Lieblong B, Stapleton T, et al.: Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study. Mol Nutr Food Res 2012,56(8):1333-41. doi:10.1002/mnfr.201100719. Epub 2012 Jun 6 10.1002/mnfr.201100719
24. Kleefstra N, Houweling ST, Jansman FG, Groenier KH, Gans RO, Meyboom-de Jong B, et al.: Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006,29(3):521-5. 10.2337/diacare.29.03.06.dc05-1453
25. Król E, Krejpcio Z, Byks H, Bogdański P, Pupek-Musialik D: Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol Trace Elem Res 2011,143(2):726-37. doi:10.1007/s12011-010-8917-5. Epub 2010 Dec 18 10.1007/s12011-010-8917-5
26. Lai MH: Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus. J Clin Biochem Nutr 2008,43(3):191-8. doi:10.3164/jcbn.2008064. Epub 2008 Oct 31 10.3164/jcbn.2008064
27. Racek J, Trefil L, Rajdl D, Mudrová V, Hunter D, Senft V: Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res 2006,109(3):215-30. 10.1385/BTER:109:3:215
28. Vrtovec M, Vrtovec B, Briski A, Kocijancic A, Anderson RA, Radovancevic B: Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus. Am Heart J 2005,149(4):632-6. 10.1016/j.ahj.2004.07.021
29. Kleefstra N, Houweling ST, Bakker SJ, Verhoeven S, Gans RO, Meyboom-de Jong B, et al.: Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2007,30(5):1092-6. Epub 2007 Feb 15 10.2337/dc06-2192
30. Schwarz K, Mertz W: Chromium(III) and the glucose tolerance factor. Arch Biochem Biophys. 1959, 85:292-5. 10.1016/0003-9861(59)90479-5