Hypertension: Renal denervation-promising data from the DENERHTN trial

Nature Reviews Nephrology

Volumn 11, Issue 5, 2015, Pages 258-259

  Yang, Wen Yi ^a   Staessen, Jan A ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; BISOPROLOL; INDAPAMIDE; IRBESARTAN; PRAZOSIN; RAMIPRIL; RILMENIDINE; SPIRONOLACTONE; ANTIHYPERTENSIVE AGENT;

AMBULATORY MONITORING; ANTIHYPERTENSIVE THERAPY; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; HOME MONITORING; HUMAN; KIDNEY DENERVATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESISTANT HYPERTENSION; SHORT SURVEY; STANDARDIZED STEPPED CARE ANTIHYPERTENSIVE TREATMENT; SYSTOLIC BLOOD PRESSURE; CATHETER ABLATION; DENERVATION; FEMALE; HYPERTENSION; MALE; PROCEDURES;

ANTIHYPERTENSIVE AGENTS; CATHETER ABLATION; DENERVATION; FEMALE; HUMANS; HYPERTENSION; MALE;

EID: 84929129658     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2015.28     Document Type: Short Survey

References (10)

1. Azizi, M. et al. Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial. Lancet 26, http://dx.doi.org/10.1016/S0140-6736(14)61942-5.
2. Bhatt, D. L. et al. A controlled trial of renal denervation for resistant hypertension. N. Engl. J. Med. 370, 1393-1401 (2014).
3. Symplicity HTN-2 Investigators et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376, 1903-1909 (2010).
4. Fadl Elmula, F. E. M. et al. Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension. Hypertension 63, 691-699 (2014).
5. Rosa, J. et al. Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 study. Hypertension 65, 407-413 (2014).
6. Staessen, J. A. et al. Antihypertensive treatment based on blood pressure measurement at home or in the physician's office. A randomized controlled trial. JAMA 291, 955-964 (2004).
7. Colloca, L. & Finniss, D. Nocebo effects, patient-clinician communication, and therapeutic outcomes. JAMA 307, 567-568 (2012).
8. Kjeldsen, S. E., Flaaten, B., Eide, I., Helgeland, A. & Leren, P. Increased peripheral release of noradrenaline and uptake of adrenaline in essential hypertension? Clin. Sci. (Lond.) 61 (Suppl. 7), 215s-217s (1981).
9. Gal, P. et al. Blood pressure response to renal nerve stimulation in patients undergoing renal denervation: a feasibility study. J. Hum. Hypertens. http://dx.doi.org/10.1038/jhh.2014.91.
10. Symplicity HTN-1 Investigators. Catheter-based renal sympathetic denervation for resistant hypertension. Durability of blood pressure reduction out to 24 months. Hypertension 57, 911-917 (2011).