Peripheral arterial disease and critical limb ischaemia: Still poor outcomes and lack of guideline adherence

European Heart Journal

Volumn 36, Issue 15, 2015, Pages 932-938

  Reinecke, Holger ^a   Unrath, Michael ^b,c   Freisinger, Eva ^a   Bunzemeier, Holger ^a   Meyborg, Matthias ^a   Luders, Florian ^a   Gebauer, Katrin ^a   Roeder, Norbert ^a   Berger, Klaus ^b   Malyar, Nasser M ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF OSNABRÜCK   (Germany)

Author keywords

Amputation; Critical limb ischaemia; Endovascular; Mortality; Peripheral arterial disease

Indexed keywords

AGED; ANGIOCARDIOGRAPHY; ARTICLE; BRAIN ISCHEMIA; CARDIAC PATIENT; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CRITICAL LIMB ISCHEMIA; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; FOLLOW UP; GERMANY; HEART FAILURE; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HOSPITAL PATIENT; HOSPITALIZATION; HOSPITALIZATION COST; HUMAN; HYPERTENSION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRACTICE GUIDELINE; PRIORITY JOURNAL; REIMBURSEMENT; RETROSPECTIVE STUDY; RISK FACTOR; SMOKING; AMPUTATION; ENDOVASCULAR SURGERY; ISCHEMIA; LEG; MIDDLE AGED; PERIPHERAL ARTERIAL DISEASE; RADIOGRAPHY; REPERFUSION; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME; VASCULARIZATION;

AMPUTATION; ENDOVASCULAR PROCEDURES; FEMALE; GUIDELINE ADHERENCE; HOSPITALIZATION; HUMANS; ISCHEMIA; LOWER EXTREMITY; MALE; MIDDLE AGED; PERIPHERAL ARTERIAL DISEASE; PRACTICE GUIDELINES AS TOPIC; REPERFUSION; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84929079755     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehv006     Document Type: Article

References (31)

1. ACCF/AHA TASK FORCE MEMBERS. 2011 ACCF/AHA Focused Update of the Guideline for the Management of patients with peripheral artery disease (Updating the 2005 Guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 2011; 124:2020-2045.
2. Rooke TW, Hirsch AT, Misra S, Sidawy AN, Beckman JA, Findeiss L, Golzarian J, Gornik HL, Jaff MR, Moneta GL, Olin JW, Stanley JC, White CJ, White JV, Zierler RE; American College of Cardiology Foundation Task Force; American Heart Association Task Force. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA Guideline Recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;61:1555-1570.
3. European Stroke Organisation, Tendera M, Aboyans V, Bartelink ML, Baumgartner I, Clement D, Collet JP, Cremonesi A, De Carlo M, Erbel R, Fowkes FG, Heras M, Kownator S, Minar E, Ostergren J, Poldermans D, Riambau V, Roffi M, Röther J, Sievert H, van Sambeek M, Zeller T; ESC Committee for Practice Guidelines. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC). Eur Heart J 2011;32:2851-2906.
4. Hirsch AT. Treatment of peripheral arterial disease-extending 'intervention' to 'therapeutic choice'. N Engl J Med 2006;354:1944-1947.
5. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG; TASC II, Working Group, Bell K, Caporusso J, Durand-Zaleski I, Komori K, Lammer J, Liapis C, Novo S, Razavi M, Robbs J, Schaper N, Shigematsu H, Sapoval M, White C, White J, Clement D, Creager M, Jaff M, Mohler E 3rd, Rutherford RB, Sheehan P, Sillesen H, Rosenfield K Inter-society consensus for the management of peripheral arterial disease (TASC II). EurJVascEndovasc Surg 2007;33(S1):S1-S75.
6. Diehm C, Allenberg JR, Pittrow D, Mahn M, Tepohl G, Haberl RL, Darius H, Burghaus I, Trampisch HJ; German Epidemiological Trial on Ankle Brachial Index Study Group. Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation 2009;120:2053-2061.
7. Becker F, Robert-Ebadi H, Ricco JB, Setacci C, Cao P, de Donato G, Eckstein HH, De Rango P, Diehm N, Schmidli J, Teraa M, Moll FL, Dick F, Davies AH, Lepäntalo M, Apelqvist J. Chapter I: definitions, epidemiology, clinical presentation and prognosis. EurJ Vasc Endovasc Surg 2011;42(S2):S4-S12.
8. Hirsch AT, Duval S. Effective vasculartherapeutics for critical limb ischemia: a role for registry-based clinical investigation. Circ Cardiovasc Interv2013;6:8-11.
9. Norgren L, Hiatt WR, Dormandy JA, Hirsch AT, Jaff MR, Diehm C, Baumgartner I, Belch JJ. The next 10 years in the management of peripheral artery disease: perspectivesfrom the 'PAD 2009' Conference. EurJ Vasc Endovasc Surg 2010;40:375-380.
10. Malyar N, Fürstenberg T, Wellmann J, Meyborg M, Lüders F, Gebauer K, Bunzemeier H, Roeder N, Reinecke H. Recent trends in morbidity and in-hospital outcomes of in-patients with peripheral arterial disease: a nationwide population-based analysis. Eur HeartJ 2013;34:2706-2714.
11. Creager MA, Kaufman JA, Conte MS. Clinical practice. Acute Limb Ischemia. N Engl J Med 2012;366:2198-2206.
12. Adam DJ, Beard JD, Cleveland T, Bell J, Bradbury AW, Forbes JF, Fowkes FG, Gillepsie I, Ruckley CV, Raab G, Storkey H; BASILTrial Participants. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial. Lancet 2005;366:1925-1934.
13. Steg PG, Bhatt DL, Wilson PW, D'Agostino R Sr, Ohman EM, Röther J, Liau CS, Hirsch AT, Mas JL, Ikeda Y, Pencina MJ, Goto S; REACH Registry Investigators. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA 2007;297:1197-1206.
14. Alberts MJ, Bhatt DL, Mas JL, Ohman EM, Hirsch AT, Röther J, Salette G, Goto S, Smith SC Jr, Liau CS, Wilson PW, Steg PG; REduction of Atherothrombosis for Continued Health Registry Investigators. Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry. Eur Heart J 2009;30:2318-2326.
15. Rastan A, Brechtel K, Krankenberg H, Zahorsky R, Tepe G, Noory E, Schwarzwälder U, Macharzina R, Schwarz T, Bürgelin K, Sixt S, Tübler T, Neumann FJ, Zeller T. Sirolimus-eluting stents for treatment of infrapopliteal arteries reduce clinical event rate compared to bare-metal stents: long-term results from a randomized trial. J Am Coll Cardiol 2012;60:587-591.
16. Liistro F, Porto I, Angioli P, Grotti S, Ricci L, Ducci K, Falsini G, Ventoruzzo G, Turini F, Bellandi G, Bolognese L. Drug-eluting balloon in peripheral intervention for below the knee angioplasty evaluation (DEBATE-BTK): a randomized trial in diabetic patients with critical limb ischemia. Circulation 2013;128:615-621.
17. Slovut DP, Sullivan TM. Critical limb ischemia: medical and surgical management. Vasc Med 2008;13:281-291.
18. Deutsche Gesellschaft für Angiologie. Leitlinien zur Diagnostik und Therapie der peripheren arteriellen Verschlusskrankheit (pAVK). S3 Leitlinie. AWMF 065-003; April 27 2009. http://www.awmf.org/uploads/tx-szleitlinien/065-003-S3- Diagnostik-und-Therapie-der-peripheren-arteriellen-Verschlusskran kheit-PAVK-03-2009-05-2012.pdf (9 Dec 2013).
19. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996;348:1329-1339.
20. Warfarin Antiplatelet Vascular Evaluation Trial Investigators, Anand S, Yusuf S, Xie C, Pogue J, Eikelboom J, Budaj A, Sussex B, Liu L, Guzman R, Cina C, Crowell R, Keltai M, Gosselin G.Oral anticoagulant and antiplatelet therapyand peripheral arterial disease. N Engl J Med 2007;357:217-227.
21. Pohlen M, Bunzemeier H, Husemann W, Roeder N, Breithardt G, Reinecke H. Risk predictors for adverse outcomes after percutaneous coronary interventions and their related costs. Clin Res Cardiol 2008;97:441-448.
22. Fiori W, Renner SP, Siam K, Babapirali J, Roeder N, Dausch E, Hildebrandt T, Hillemanns P, Nehmzow M, Zygmunt M, Piroth D, Schem C, Schwenzer T, Friese K, Wallwiener D, Beckmann MW. Shaping the system-the DRG evaluation project of the German Society for Gynaecology and Obestetrics. Geburtsh Frauen-heilk 2013;73:776-782.
23. Hagel S, Brunkhorst FM. Sepsis. Intensivmed 2011;48:57-73.
24. Rollins KE, Jackson D, Coughlin PA. Meta-analysis of contemporary short-and longterm mortality rates in patients diagnosed with critical leg ischaemia. Br J Surg 2013; 100:1002-1008.
25. Abola MT, Bhatt DL, Duval S, Cacoub PP, Baumgartner I, Keo H, Creager MA, Brennan DM, Steg PG, Hirsch AT; REACH Investigators. Fate of individuals with ischemic amputations in the REACH Registry: three-year cardiovascular and limb-related outcomes. Atherosclerosis 2012;221:527-535.
26. Siegel R, Naishadham D, Jemal A. Cancer statistics 2013. CA Cancer J Clin 2013;63: 11-30.
27. Faglia E, Clerici G, Clerissi J, Gabrielli L, Losa S, Mantero M, Caminiti M, Curci V, Quarantiello A, Lupattelli T, Morabito A. Long-term prognosis of diabetic patients with critical limb ischemia: a population-based cohort study. Diabetes Care 2009; 32:822-827.
28. Rowe VL, Lee W, Weaver FA, Etzioni D. Patterns oftreatment for peripheral arterial disease in the United States: 1996-2005. J Vasc Surg 2009;49:910-917.
29. Sachs T, Pomposelli F, Hamdan A, Wyers M, Schermerhorn M.Trends inthe national outcomes and costs for claudication and limb threatening ischemia: angioplasty vs bypass graft. J Vasc Surg 2011;54:1021-1031.
30. Goodney PP, Travis LL, Nallamothu BK, Holman K, Suckow B, Henke PK, Lucas FL, Goodman DC, Birkmeyer JD, Fisher ES. Variation in the use of lower extremity vascular procedures for critical limb ischemia. Circ Cardiovasc Qual Outcomes 2012;5: 94-102.
31. Holman KH, Henke PK, Dimick JB, Birkmeyer JD. Racial disparities in the use of re-vascularization before leg amputation in Medicare patients. J Vasc Surg 2011;54: 420-426.