Immune response, safety, and survival and quality of life outcomes for advanced colorectal cancer patients treated with dendritic cell vaccine and cytokine-induced killer cell therapy

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Zhu, Hui ^a   Yang, Xuejing ^b   Li, Jiali ^a   Ren, Yanjie ^b   Zhang, Tianyu ^b   Zhang, Chunze ^a   Zhang, Jintai ^a   Li, Jing ^a   Pang, Yan ^a  

^a Tianjin Union Medicine Centre   (China)

^b Shanghai Claison Biotechnology Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CANCER VACCINE; CD3 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CD83 ANTIGEN; DENDRITIC CELL VACCINE;

ADULT; ADVANCED CANCER; AGED; ANOREXIA; APPETITE; ARTHRALGIA; ARTICLE; BODY WEIGHT; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CELLULAR IMMUNITY; COLORECTAL CANCER; CONTROLLED STUDY; CYTOKINE INDUCED KILLER CELL; DELAYED HYPERSENSITIVITY; DRUG SAFETY; FEMALE; FEVER; FOLLOW UP; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; OVERALL SURVIVAL; PARALLEL DESIGN; PHYSICAL CAPACITY; QUALITY OF LIFE; RASH; RETROSPECTIVE STUDY; SLEEP; ADVERSE DRUG REACTION; BIOLOGICAL THERAPY; CLINICAL TRIAL; COLORECTAL NEOPLASMS; DENDRITIC CELL; GENETICS; IMMUNOLOGY; KAPLAN MEIER METHOD; MIDDLE AGED; PATHOLOGY; TREATMENT OUTCOME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CANCER VACCINES; CELL- AND TISSUE-BASED THERAPY; COLORECTAL NEOPLASMS; CYTOKINE-INDUCED KILLER CELLS; DENDRITIC CELLS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; HUMANS; IMMUNITY, CELLULAR; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 84929057176     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/603871     Document Type: Article

References (32)

1. P. Boyle and M. E. Leon, "Epidemiology of colorectal cancer, " The British Medical Bulletin, vol. 64, pp. 1-25, 2002.
2. E. T. Hawk, P. J. Limburg, and J. L. Viner, "Epidemiology and prevention of colorectal cancer, " Surgical Clinics of North America, vol. 82, no. 5, pp. 905-941, 2002.
3. A. Shin, K. Z. Kim, K. W. Jung et al. , "Increasing trend of colorectal cancer incidence in Korea, 1999-2009, " Cancer Research and Treatment, vol. 44, no. 4, pp. 219-226, 2012.
4. D. C. Damin and R. A. Lazzaron, "Evolving treatment strategies for colorectal cancer: a critical review of current therapeutic options, " World Journal of Gastroenterology, vol. 20, no. 4, pp. 877-887, 2014.
5. T.-W. Ke, Y.-M. Liao, H.-C. Chiang et al. , "Effectiveness of neoadjuvant concurrent chemoradiotherapy versus up-front proctectomy in clinical stage II-III rectal cancer: a populationbased study, " Asia-Pacific Journal of Clinical Oncology, 2014.
6. M. Laurent, E. Paillaud, C. Tournigand et al. , "Assessment of solid cancer treatment feasibility in older patients: a prospective cohort study, " Oncologist, vol. 19, no. 3, pp. 275-282, 2014.
7. M. Z. Ratajczak, T. Jadczyk, G. Schneider, S. S. Kakar, and M. Kucia, "Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy, " Journal ofOvarian Research, vol. 6, no. 1, article 95, 2013.
8. P. C. Kurniali, L. G. Luo, and A. B. Weitberg, "Role of calcium/ magnesium infusion in oxaliplatin-based chemotherapy for colorectal cancer patients, " Oncology, vol. 24, no. 3, pp. 289-292, 2010.
9. D. J. Gallagher and N. Kemeny, "Metastatic colorectal cancer: fromimproved survival to potential cure, " Oncology, vol. 78, no. 3-4, pp. 237-248, 2010.
10. S. Koido, T. Ohkusa, S. Homma et al. , "Immunotherapy for colorectal cancer, "World Journal of Gastroenterology, vol. 19, no. 46, pp. 8531-8542, 2013.
11. E. Ellebaek, M. H. Andersen, I. M. Svane, and P. T. Straten, "Immunotherapy for metastatic colorectal cancer: present status and new options, " Scandinavian Journal of Gastroenterology, vol. 47, no. 3, pp. 315-324, 2012.
12. B. Xiang, A. E. Snook, M. S. Magee, and S. A. Waldman, "Colorectal cancer immunotherapy, " Discovery Medicine, vol. 15, no. 84, pp. 301-308, 2013.
13. P. G. Toomey, N. A. Vohra, T. Ghansah, A. A. Sarnaik, and S. A. Pilon-Thomas, "Immunotherapy for gastrointestinal malignancies, " Cancer Control, vol. 20, no. 1, pp. 32-42, 2013.
14. A. Amedei, E. Niccolai, and M. M. DElios, "T cells and adoptive immunotherapy: recent developments and future prospects in gastrointestinal oncology, " Clinical and Developmental Immunology, vol. 2011, Article ID 320571, 17 pages, 2011.
15. Y. Cui, X. Yang, W. Zhu, J. Li, X. Wu, and Y. Pang, "Immune response, clinical outcome and safety of dendritic cell vaccine in combination with cytokine-induced killer cell therapy in cancer patients, " Oncology Letters, vol. 6, no. 2, pp. 537-541, 2013.
16. M. N. Ĺopez, C. Pereda, G. Segal et al. , "Prolonged survival of dendritic cell-vaccinated melanoma patients correlates with tumor-specific delayed type IV hypersensitivity response and reduction of tumor growth factor β-expressing T cells, " Journal of Clinical Oncology, vol. 27, no. 6, pp. 945-952, 2009.
17. P. A. Burch, J. K. Breen, J. C. Buckner et al. , "Priming tissuespecific cellular immunity in a phase I trial of autologous dendritic cells for prostate cancer, " Clinical Cancer Research, vol. 6, no. 6, pp. 2175-2182, 2000.
18. Y. Liu, W. Zhang, B. Zhang, X. Yin, and Y. Pang, "DC vaccine therapy combined concurrently with oral capecitabine in metastatic colorectal cancer patients, "Hepato-Gastroenterology, vol. 60, no. 122, pp. 23-27, 2013.
19. A. D. Garg, A. M. Dudek, and P. Agostinis, "utophagydependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity, " Oncoimmunology, vol. 2, no. 10, Article IDe26260, 2013.
20. L. Galluzzi, L. Senovilla, E. Vacchelli et al. , "Trial watch: dendritic cell-based interventions for cancer therapy, " Oncoimmunology, vol. 1, no. 7, pp. 1111-1134, 2012.
21. H. Ragde, W. A. Cavanagh, and B. A. Tjoa, "Dendritic cell based vaccines: progress in immunotherapy studies for prostate cancer, " Journal of Urology, vol. 172, no. 6, pp. 2532-2538, 2004.
22. K. F. Bol, J. Tel, I. J. de Vries, and C. G. Figdor, "Naturally circulating dendritic cells to vaccinate cancer patients, " Oncoimmunology, vol. 2, no. 3, Article ID e23431, 2013.
23. J. Tel, E. L. Smits, S. Anguille, R. N. Joshi, C. G. Figdor, and I. J. M. de Vries, "Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities, " Blood, vol. 120, no. 19, pp. 3936-3944, 2012.
24. X. Wang, W. H. Yu, J. Li et al. , "Can the dual-functional capability of CIK cells be used to improve antitumor effects?" Cellular Immunology, vol. 287, no. 1, pp. 18-22, 2014.
25. C. E. Jäkel, S. Hauser, S. Rogenhofer, S. C. Müller, P. Brossart, and I. G. H. Schmidt-Wolf, "Clinical studies applying cytokineinduced killer cells for the treatment of renal cell carcinoma, " Clinical and Developmental Immunology, vol. 2012, Article ID 473245, 7 pages, 2012.
26. J. Yu, X. Ren, H. Li et al. , "Synergistic effect of CH-296 and interferon gamma on cytokine-induced killer cells expansion for patients with advanced-stage malignant solid tumors, " Cancer Biotherapy & Radiopharmaceuticals, vol. 26, no. 4, pp. 485-494, 2011.
27. G. Mesiano, M. Todorovic, L. Gammaitoni et al. , "Cytokineinduced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors, " Expert Opinion on BiologicalTherapy, vol. 12, no. 6, pp. 673-684, 2012.
28. S. Shi, R. Wang, Y. Chen, H. Song, L. Chen, and G. Huang, "Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models, " PLoS ONE, vol. 8, no. 6, Article ID e65757, 2013.
29. K. Hasumi, Y. Aoki, R. Wantanabe, and D. L. Mann, "Clinical response of advanced cancer patients to cellular immunotherapy and intensity-modulated radiation therapy, " Oncoimmunology, vol. 2, no. 10, Article IDe26381, 2013.
30. R. Zhong, J. Teng, B. Han, and H. Zhong, "Dendritic cells combining with cytokine-induced killer cells synergize chemotherapy in patients with late-stage non-small cell lung cancer, " Cancer Immunology, Immunotherapy, vol. 60, no. 10, pp. 1497-1502, 2011.
31. H. Zhan, X. Gao, X. Pu et al. , "A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokineinduced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma, " Chinese Medical Journal, vol. 125, no. 21, pp. 3771-3777, 2012.
32. L. Yin, S. Wang, L. Zhang et al. , "Efficacy of dendritic cells/cytokine induced killer cells adoptive immunotherapy combined with chemotherapy in treatment of metastatic colorectal cancer, " Chinese Journal of Cancer Biotherapy, vol. 20, no. 2, pp. 217-224, 2013.