Randomized, Double-Blinded, Clinical Trial of Propofol, 1:1 Propofol/Ketamine, and 4:1 Propofol/Ketamine for Deep Procedural Sedation in the Emergency Department

Annals of Emergency Medicine

Volumn 65, Issue 5, 2015, Pages

  Miner, James R ^a   Moore, Johanna C ^a   Austad, Erin J ^a   Plummer, David ^a   Hubbard, Laura ^a   Gray, Richard O ^a  

^a HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEMETIC AGENT; ATROPINE; DIPHENHYDRAMINE; HYDROMORPHONE; KETAMINE; MORPHINE; PROPOFOL; ANESTHETIC AGENT; DRUG COMBINATION; HYPNOTIC SEDATIVE AGENT;

ADULT; AGED; AGITATION; ANALGESIA; ANESTHESIA LEVEL; ANESTHETIC RECOVERY; ARTICLE; ASSISTED VENTILATION; CENTRAL APNEA; CLINICAL TRIAL; CONTROLLED STUDY; DEEP PROCEDURAL SEDATION; DEEP SEDATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED DISEASE; DYSTONIA; EMERGENCY WARD; FEMALE; HUMAN; HYPOXIA; MAJOR CLINICAL STUDY; MALE; MEDICAL PARAMETERS; NECK RASH; OXYGEN SATURATION; OXYGEN THERAPY; PAIN; PAROTID SWELLING; PATIENT SATISFACTION; PRIORITY JOURNAL; PROCEDURAL RECALL; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; URTICARIA; VERY ELDERLY; VOMITING; ADOLESCENT; ADVERSE EFFECTS; CHEMICALLY INDUCED; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG COMBINATION; EMERGENCY HEALTH SERVICE; MIDDLE AGED; OUTCOME ASSESSMENT; PROCEDURES; RESPIRATION DISORDERS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANESTHETICS, DISSOCIATIVE; DEEP SEDATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; KETAMINE; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PROPOFOL; RESPIRATION DISORDERS; YOUNG ADULT;

EID: 84929031620     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2014.08.046     Document Type: Article

References (43)

1. R.E. O'Connor, A. Sama, J.H. Burton, et al. Procedural sedation and analgesia in the emergency department: recommendations for physician credentialing, privileging, and practice Ann Emerg Med 58 2011 365 370
2. K.E. Bassett, J.L. Anderson, C.G. Pribble, et al. Propofol for procedural sedation in children in the emergency department Ann Emerg Med 42 2003 773 782
3. J.R. Miner, M. Biros, S. Krieg, et al. Randomized clinical trial of propofol versus methohexital for procedural sedation during fracture and dislocation reduction in the emergency department Acad Emerg Med 10 2003 931 937
4. J.R. Miner, and J.H. Burton Clinical practice advisory: emergency department procedural sedation with propofol Ann Emerg Med 50 2007 182 187 187.e181
5. J.R. Miner, M. Danahy, A. Moch, et al. Randomized clinical trial of etomidate versus propofol for procedural sedation in the emergency department Ann Emerg Med 49 2007 15 22
6. J.R. Miner, R.O. Gray, J. Bahr, et al. Randomized clinical trial of propofol versus ketamine for procedural sedation in the emergency department Acad Emerg Med 17 2010 604 611
7. J.R. Miner, R.O. Gray, D. Stephens, et al. Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department Acad Emerg Med 16 2009 825 834
8. S.M. Green, M.G. Roback, R.M. Kennedy, et al. Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update Ann Emerg Med 57 2011 449 461
9. S.M. Green, and B. Krauss Clinical practice guideline for emergency department ketamine dissociative sedation in children Ann Emerg Med 44 2004 460 471
10. S.M. Green, and B. Krauss Ketamine is a safe, effective, and appropriate technique for emergency department paediatric procedural sedation Emerg Med J 21 2004 271 272
11. M.J. Alletag, M.A. Auerbach, and C.R. Baum Ketamine, propofol, and ketofol use for pediatric sedation Pediatr Emerg Care 28 2012 1391 1395 quiz 1396-1398
12. S.M. Green, M.G. Roback, B. Krauss, et al. Predictors of airway and respiratory adverse events with ketamine sedation in the emergency department: an individual-patient data meta-analysis of 8,282 children Ann Emerg Med 54 2009 158 168 e151-154
13. S.M. Green, M.G. Roback, B. Krauss, et al. Predictors of emesis and recovery agitation with emergency department ketamine sedation: an individual-patient data meta-analysis of 8,282 children Ann Emerg Med 54 2009 171 180 e171-174
14. G. Andolfatto, R.B. Abu-Laban, P.J. Zed, et al. Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial Ann Emerg Med 59 2012 504 512 e501-502
15. G. Andolfatto, and E. Willman A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol) Acad Emerg Med 17 2010 194 201
16. G. Andolfatto, and E. Willman A prospective case series of single-syringe ketamine-propofol (ketofol) for emergency department procedural sedation and analgesia in adults Acad Emerg Med 18 2011 237 245
17. S. Arora Combining ketamine and propofol ("ketofol") for emergency department procedural sedation and analgesia: a review West J Emerg Med 9 2008 20 23
18. P.S. da Silva, V.E. de Aguiar, D.R. Waisberg, et al. Use of ketofol for procedural sedation and analgesia in children with hematological diseases Pediatr Int 53 2011 62 67
19. G. Erdogan Kayhan, A. Yucel, Y.Z. Colak, et al. Ketofol (mixture of ketamine and propofol) administration in electroconvulsive therapy Anaesth Intensive Care 40 2012 305 310
20. M.A. Erdogan, Z. Begec, M.S. Aydogan, et al. Comparison of effects of propofol and ketamine-propofol mixture (ketofol) on laryngeal mask airway insertion conditions and hemodynamics in elderly patients: a randomized, prospective, double-blind trial J Anesth 27 2013 12 17
21. S.M. Green, G. Andolfatto, and B. Krauss Ketofol for procedural sedation? pro and con Ann Emerg Med 57 2011 444 448
22. G. Loh, and D. Dalen Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department Ann Pharmacother 41 2007 485 492
23. A. Nejati, R.S. Moharari, H. Ashraf, et al. Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial Acad Emerg Med 18 2011 800 806
24. W. Phillips, A. Anderson, M. Rosengreen, et al. Propofol versus propofol/ketamine for brief painful procedures in the emergency department: clinical and bispectral index scale comparison J Pain Palliat Care Pharmacother 24 2010 349 355
25. D.A. Rapeport, J.W. Martyr, and L.P. Wang The use of "ketofol" (ketamine-propofol admixture) infusion in conjunction with regional anaesthesia Anaesth Intensive Care 37 2009 121 123
26. B.D. Shy, R.J. Strayer, and M.A. Howland Independent dosing of propofol and ketamine may improve procedural sedation compared with the combination "ketofol." Ann Emerg Med 61 2013 257
27. N.J. Smischney, M.L. Beach, R.W. Loftus, et al. Ketamine/propofol admixture (ketofol) is associated with improved hemodynamics as an induction agent: a randomized, controlled trial J Trauma Acute Care Surg 73 2012 94 101
28. A. Weatherall, and R. Venclovas Experience with a propofol-ketamine mixture for sedation during pediatric orthopedic surgery Paediatr Anaesth 20 2010 1009 1016
29. E.V. Willman, and G. Andolfatto A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department Ann Emerg Med 49 2007 23 30
30. S. Yalcin, H. Aydogan, S. Selek, et al. Ketofol in electroconvulsive therapy anesthesia: two stones for one bird J Anesth 26 2012 562 567
31. A. Zonca, G. Ravasio, M. Gallo, et al. Pharmacokinetics of ketamine and propofol combination administered as ketofol via continuous infusion in cats J Vet Pharmacol Ther 35 2012 580 587
32. H. David, and J. Shipp A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation Ann Emerg Med 57 2011 435 441
33. M. Daabiss, M. Elsherbiny, and R. Alotibi Assesment of different concentration of ketofol in procedural operation Br J Med Practitioners 2 2009 27 31
34. American Society of Anesthesiologists. Physical status classification system. Available at: http://www.asahq.org/clinical/physicalstatus.htm. Accessed March 30, 2004.
35. M.N. Avramov, and P.F. White Methods for monitoring the level of sedation Crit Care Clin 11 1995 803 826
36. J.H. Burton, J.D. Harrah, C.A. Germann, et al. Does end-tidal carbon dioxide monitoring detect respiratory events prior to current sedation monitoring practices? Acad Emerg Med 13 2006 500 504
37. J.R. Miner, M.H. Biros, W. Heegaard, et al. Bispectral electroencephalographic analysis of patients undergoing procedural sedation in the emergency department Acad Emerg Med 10 2003 638 643
38. J.R. Miner, M.H. Biros, T. Seigel, et al. The utility of the bispectral index in procedural sedation with propofol in the emergency department Acad Emerg Med 12 2005 190 196
39. J.R. Miner, W. Heegaard, and D. Plummer End-tidal carbon dioxide monitoring during procedural sedation Acad Emerg Med 9 2002 275 280
40. C. Kerssens, J. Klein, and B. Bonke Awareness: monitoring versus remembering what happened Anesthesiology 99 2003 570 575
41. M. Bhatt, R.M. Kennedy, M.H. Osmond, et al. Consensus-based recommendations for standardizing terminology and reporting adverse events for emergency department procedural sedation and analgesia in children Ann Emerg Med 53 2009 426 435 e424
42. J.R. Miner, A. Bachman, L. Kosman, et al. Assessment of the onset and persistence of amnesia during procedural sedation with propofol Acad Emerg Med 12 2005 491 496
43. J.R. Miner, J.C. Moore, D. Plummer, et al. Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines Acad Emerg Med 20 2013 330 337