메뉴 건너뛰기




Volumn 16, Issue 6, 2014, Pages 463-470

Chronic Pancreatitis and Systemic Inflammatory Response Syndrome Prevent Impact of Chemotherapy with Gemcitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84929030168     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1016/j.neo.2014.05.010     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 84890446273 scopus 로고    scopus 로고
    • Pancreatic cancer death rates by race among US men and women, 1970-2009
    • Ma J, Siegel R, Jemal A Pancreatic cancer death rates by race among US men and women, 1970-2009. J Natl Cancer Inst 2013, 105:1694-1700.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1694-1700
    • Ma, J.1    Siegel, R.2    Jemal, A.3
  • 2
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997, 15:2403-2413.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 3
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • Colucci G, Giuliani F, Gebbia V, Biglietto M, Rabitti P, Uomo G, et al. Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 2002, 94:902-911.
    • (2002) Cancer , vol.94 , pp. 902-911
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3    Biglietto, M.4    Rabitti, P.5    Uomo, G.6
  • 4
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, Steward W, et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol 2009, 27:5513-5518.
    • (2009) J Clin Oncol , vol.27 , pp. 5513-5518
    • Cunningham, D.1    Chau, I.2    Stocken, D.D.3    Valle, J.W.4    Smith, D.5    Steward, W.6
  • 5
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial
    • Louvet C, Labianca R, Hammel P, Lledo G, Zampino MG, André T, et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 2005, 23:3509-3516.
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3    Lledo, G.4    Zampino, M.G.5    André, T.6
  • 6
    • 27144530079 scopus 로고    scopus 로고
    • A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unrespectable or metastatic pancreatic cancer
    • Oettle H, Richards D, Ramanathan RK, van Laethem JL, Peeters M, Fuchs M, et al. A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unrespectable or metastatic pancreatic cancer. Ann Oncol 2005, 16:1639-1645.
    • (2005) Ann Oncol , vol.16 , pp. 1639-1645
    • Oettle, H.1    Richards, D.2    Ramanathan, R.K.3    van Laethem, J.L.4    Peeters, M.5    Fuchs, M.6
  • 7
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • Rocha Lima CM, Green MR, Rotche R, Miller WH, Jeffrey GM, Cisar LA, et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 2004, 22:3776-3783.
    • (2004) J Clin Oncol , vol.22 , pp. 3776-3783
    • Rocha Lima, C.M.1    Green, M.R.2    Rotche, R.3    Miller, W.H.4    Jeffrey, G.M.5    Cisar, L.A.6
  • 9
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007, 25:1960-1966.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6
  • 11
    • 0037329813 scopus 로고    scopus 로고
    • Systemic inflammatory response predicts survival following curative resection of colorectal cancer
    • McMillan DC, Canna K, McArdle CS Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 2003, 90:215-219.
    • (2003) Br J Surg , vol.90 , pp. 215-219
    • McMillan, D.C.1    Canna, K.2    McArdle, C.S.3
  • 12
    • 85047693449 scopus 로고    scopus 로고
    • Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma
    • Ikeda M, Natsugoe S, Ueno S, Baba M, Aikou T Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma. Ann Surg 2003, 238:197-202.
    • (2003) Ann Surg , vol.238 , pp. 197-202
    • Ikeda, M.1    Natsugoe, S.2    Ueno, S.3    Baba, M.4    Aikou, T.5
  • 13
    • 0025228036 scopus 로고
    • Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6
    • Castell JV, Gomez-Lechon MJ, David M, Fabra R, Trullenque R, Heinrich PC Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 1990, 12:1179-1186.
    • (1990) Hepatology , vol.12 , pp. 1179-1186
    • Castell, J.V.1    Gomez-Lechon, M.J.2    David, M.3    Fabra, R.4    Trullenque, R.5    Heinrich, P.C.6
  • 14
    • 0033673070 scopus 로고    scopus 로고
    • Prognostic factors in patients with metastatic pancreatic adenocarcinoma receiving systemic chemotherapy
    • Ueno H, Okada S, Okusaka T, Ikeda M Prognostic factors in patients with metastatic pancreatic adenocarcinoma receiving systemic chemotherapy. Oncology 2000, 59:296-301.
    • (2000) Oncology , vol.59 , pp. 296-301
    • Ueno, H.1    Okada, S.2    Okusaka, T.3    Ikeda, M.4
  • 16
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H, Pardoll D, Jove R STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009, 9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 17
    • 4944239032 scopus 로고    scopus 로고
    • Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
    • Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, et al. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest 2004, 114:720-728.
    • (2004) J Clin Invest , vol.114 , pp. 720-728
    • Chan, K.S.1    Sano, S.2    Kiguchi, K.3    Anders, J.4    Komazawa, N.5    Takeda, J.6
  • 18
    • 23844445451 scopus 로고    scopus 로고
    • Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling
    • Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, et al. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med 2005, 11:845-852.
    • (2005) Nat Med , vol.11 , pp. 845-852
    • Jenkins, B.J.1    Grail, D.2    Nheu, T.3    Najdovska, M.4    Wang, B.5    Waring, P.6
  • 20
    • 10944236962 scopus 로고    scopus 로고
    • Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
    • Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 2004, 119:847-860.
    • (2004) Cell , vol.119 , pp. 847-860
    • Olive, K.P.1    Tuveson, D.A.2    Ruhe, Z.C.3    Yin, B.4    Willis, N.A.5    Bronson, R.T.6
  • 22
    • 77951744260 scopus 로고    scopus 로고
    • The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    • Fendrich V, Chen NM, Neef M, Waldmann J, Bucholz M, Feldmann G, et al. The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. Gut 2010, 59:630-637.
    • (2010) Gut , vol.59 , pp. 630-637
    • Fendrich, V.1    Chen, N.M.2    Neef, M.3    Waldmann, J.4    Bucholz, M.5    Feldmann, G.6
  • 23
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005, 7:469-483.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5    Hruban, R.H.6
  • 24
    • 80155134032 scopus 로고    scopus 로고
    • Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors
    • Fendrich V, Rehm J, Waldmann J, Buchholz M, Christofori G, Lauth M, et al. Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors. Ann Surg 2011, 254:818-823.
    • (2011) Ann Surg , vol.254 , pp. 818-823
    • Fendrich, V.1    Rehm, J.2    Waldmann, J.3    Buchholz, M.4    Christofori, G.5    Lauth, M.6
  • 25
    • 79951477833 scopus 로고    scopus 로고
    • Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer
    • Fendrich V, Schneider R, Maitra A, Jacobsen ID, Opfermann T, Bartsch DK Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer. Neoplasia 2011, 13:180-186.
    • (2011) Neoplasia , vol.13 , pp. 180-186
    • Fendrich, V.1    Schneider, R.2    Maitra, A.3    Jacobsen, I.D.4    Opfermann, T.5    Bartsch, D.K.6
  • 26
    • 13244284643 scopus 로고    scopus 로고
    • Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas
    • Jamieson NB, Glen P, McMillan DC, McKay CJ, Foulis AK, et al. Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas. Br J Cancer 2005, 92:21-23.
    • (2005) Br J Cancer , vol.92 , pp. 21-23
    • Jamieson, N.B.1    Glen, P.2    McMillan, D.C.3    McKay, C.J.4    Foulis, A.K.5
  • 27
    • 34447620154 scopus 로고    scopus 로고
    • Prognostic factors in patients with gemcitabine-refractory pancreatic cancer
    • Nakachi K, Furuse J, Ishii H, Suzuki E, Yoshino M Prognostic factors in patients with gemcitabine-refractory pancreatic cancer. Jpn J Clin Oncol 2007, 37:114-120.
    • (2007) Jpn J Clin Oncol , vol.37 , pp. 114-120
    • Nakachi, K.1    Furuse, J.2    Ishii, H.3    Suzuki, E.4    Yoshino, M.5
  • 28
    • 34248579658 scopus 로고    scopus 로고
    • Predictive factors in pancreatic ductal adenocarcinoma: role of the inflammatory response
    • Tingstedt B, Johansson P, Andersson B, Andersson R Predictive factors in pancreatic ductal adenocarcinoma: role of the inflammatory response. Scand J Gastroenterol 2007, 42:754-759.
    • (2007) Scand J Gastroenterol , vol.42 , pp. 754-759
    • Tingstedt, B.1    Johansson, P.2    Andersson, B.3    Andersson, R.4
  • 30
    • 0042825695 scopus 로고    scopus 로고
    • Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer
    • Scholz A, Heinze S, Detjen KM, Peters M, Welzel M, Hauff P, et al. Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 2003, 125:891-905.
    • (2003) Gastroenterology , vol.125 , pp. 891-905
    • Scholz, A.1    Heinze, S.2    Detjen, K.M.3    Peters, M.4    Welzel, M.5    Hauff, P.6
  • 31
    • 0142122338 scopus 로고    scopus 로고
    • Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer
    • Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, et al. Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. Cancer Lett 2003, 01:107-116.
    • (2003) Cancer Lett , vol.1 , pp. 107-116
    • Toyonaga, T.1    Nakano, K.2    Nagano, M.3    Zhao, G.4    Yamaguchi, K.5    Kuroki, S.6
  • 32
    • 22744433845 scopus 로고    scopus 로고
    • The transcription factor Stat3 is dispensable for pancreatic beta-cell development and function
    • Lee JY, Hennighausen L The transcription factor Stat3 is dispensable for pancreatic beta-cell development and function. Biochem Biophys Res Commun 2005, 334:764-768.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 764-768
    • Lee, J.Y.1    Hennighausen, L.2
  • 33
    • 33744813002 scopus 로고    scopus 로고
    • Persistent expression of PDX-1 in the pancreas causes acinarto- ductal metaplasia through Stat3 activation
    • Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, et al. Persistent expression of PDX-1 in the pancreas causes acinarto- ductal metaplasia through Stat3 activation. Genes Dev 2006, 20:1435-1440.
    • (2006) Genes Dev , vol.20 , pp. 1435-1440
    • Miyatsuka, T.1    Kaneto, H.2    Shiraiwa, T.3    Matsuoka, T.A.4    Yamamoto, K.5    Kato, K.6
  • 34
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • Fukuda A, Wang SC, Morris JP, Folias AE, Liou A, Kim GE, et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell 2011, 19:441-455.
    • (2011) Cancer Cell , vol.19 , pp. 441-455
    • Fukuda, A.1    Wang, S.C.2    Morris, J.P.3    Folias, A.E.4    Liou, A.5    Kim, G.E.6
  • 35
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011, 19:456-469.
    • (2011) Cancer Cell , vol.19 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3    Rose-John, S.4    Treiber, M.5    Klöppel, G.6
  • 36
    • 84869192369 scopus 로고    scopus 로고
    • Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction
    • Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, Uemura A, et al. Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction. Am J Pathol 2012, 181:2105-2113.
    • (2012) Am J Pathol , vol.181 , pp. 2105-2113
    • Shigekawa, M.1    Hikita, H.2    Kodama, T.3    Shimizu, S.4    Li, W.5    Uemura, A.6
  • 37
    • 33847414390 scopus 로고    scopus 로고
    • A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers
    • Murtaugh LC, Leach SD A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers. Cancer Cell 2007, 1:211-213.
    • (2007) Cancer Cell , vol.1 , pp. 211-213
    • Murtaugh, L.C.1    Leach, S.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.