The integration of social, behavioral, and biological mechanisms in models of pathogenesis

Perspectives in Biology and Medicine

Volumn 57, Issue 3, 2015, Pages 308-328

  Kelly, Michael P ^a   Kelly, Rachel S ^b   Russo, Federica ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE MEDICINE; HUMAN; ILLNESS BEHAVIOR; INTEGRATED HEALTH CARE SYSTEM; NONBIOLOGICAL MODEL; ORGANIZATION AND MANAGEMENT; PUBLIC HEALTH; SOCIAL STATUS; SOCIOECONOMICS;

COMPLEMENTARY THERAPIES; DELIVERY OF HEALTH CARE, INTEGRATED; HUMANS; ILLNESS BEHAVIOR; MODELS, ORGANIZATIONAL; PUBLIC HEALTH; SOCIAL CONDITIONS; SOCIOECONOMIC FACTORS;

EID: 84928987799     PISSN: 00315982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (104)

1. Anderson, Olivia S., Karilyn E. Sant, and Dana C. Dolinoy. 2012. “Nutrition and Epigenetics: An Interplay of Dietary Methyl Donors, One-Carbon Metabolism and DNA Methylation.” J Nutr Biochem23 (8): 853–59.
2. Antonovsky, Aaron. 1985. Health Stress and Coping. San Francisco: Jossey Bass.
3. Antonovsky, Aaron. 1987. Unravelling the Mystery of Health: How People Manage Stress and Stay Well. San Francisco: Jossey Bass.
4. Barker, David J. 1991. “The Foetal and Infant Origins of Inequalities in Health in Britain.” J Public Health Med13 (2): 64–68.
5. Barker, David J., and C. N. Martyn. 1992. “The Maternal and Foetal Origins of Cardiovascular Disease.” BMJ304: 9–11.
6. Barker, David J., and C. Osmond. 1987. “Inequalities in Health in Britain: Specific Explanations in Three Lancashire Towns.” BMJ294: 749–52.
7. Barker, David J., et al. 2013. “Support Mothers to Secure Future Public Health.” Nature504 (7479): 209–11.
8. Beaglehole, Robert, et al. 2012. “Measuring Progress on NCDs: One Goal and Five Targets.” Lancet380 (9850): 1283–85.
9. Berkman, Lisa F., et al. 2000. “From Social Integration to Health: Durkheim in the New Millennium.” Soc Sci Med51 (6): 843–57.
10. Borghol, N., et al. 2012. “Associations with Early-Life Socio-Economic Position in Adult DNA Methylation.” Int J Epidemiol41 (1): 62–74.
11. Blas, Erik, et al. 2008. “Addressing Social Determinants of Health Inequities: What Can the State and Civil Society Do?” Lancet372 (9650): 1684–89.
12. Blue, Stanley, et al. 2014. “Theories of Practice and Public Health: Understanding (Un) healthy Practices.” Crit Public Health. doi: 10.1080/09581596.2014.980396.
13. Blumenshine, Philip, et al. 2008. “Pandemic Influenza Planning in the United States from a Health Disparities Perspective.” Emerg Infect Dis14 (5): 709–15.
14. Broadbent, Alex. 2011. Epidemiology, Risk and Causation: Conceptual, Methodological Issues in Public Health Science. Cambridge: PHG Foundation.
15. Brown, George W., Maire N. Bhrolchain, and Tirril Harris. 1975. “Social Class and Psychiatric Disturbance Among Women in an Urban Population.” Sociology9 (2): 225–54.
16. Buck, David, and Francesca Frosini. 2012. Clustering of Unhealthy Behaviours over Time: Implications for Policy and Practice. London: King’s Fund.
17. Cacioppo, John T., and Stephanie Cacioppo. 2013. “Social Neuroscience.” Perspect Psychol Sci8 (6): 667–69. doi: 10.1177/1745691613507456.
18. Carter, K. Codell. 2003. The Rise of Causal Concepts of Disease: Case Histories. Aldershot: Ashgate.
19. Clarke Brendan, et al. 2014. “Mechanisms and the Evidence Hierarchy.” Topoi33: 339–60.
20. Cobb, Sidney. 1976. “Social Support as a Moderator of Life Stress.” Psychosom Med38: 300– 314.
21. Cockerham, William C. 2007. Social Causes of Health and Disease. Cambridge: Polity.
22. Commission on the Social Determinants of Health (CSDH). 2008. Closing the Gap in a Generation: Health Equity Through Action on the Social Determinants of Health. Geneva: WHO. http://whqlibdoc.who.int/publications/2008/9789241563703_eng.pdf?ua=1.
23. Davies, Sally C. 2013. The Drugs Don’t Work. London: Penguin.
24. Department of Health. 1999. Saving Lives: Our Healthier Nation. London: Stationery Office.
25. Department of Health. 2002. Tackling Health Inequalities: 2002 Cross-Cutting Review. London: Department of Health.
26. Engel, George L. 1960. “A Unified Concept of Health and Disease.” Perspect Biol Med3 (4): 459–85.
27. Engel, George L. 1981. “The Clinical Application of the Biopsychosocial Model.” J Med Philos6 (2): 101–24; originally published 1980 in Am J Psychiatry 137: 535–44.
28. Evans, Robert G., and Greg L. Stoddart. 2003. “Consuming Research, Producing Policy.” Am J Public Health93 (3): 371–79.
29. Ferguson, Thomas. 1948. The Dawn of Scottish Social Welfare: A Survey from Medieval Times to 1863. London: Nelson
30. Frazer, W. M. 1947. Duncan of Liverpool: Being an Account of the Work of Dr W. H. Duncan, Medical Officer of Health of Liverpool, 1847–63. London: Hamish Hamilton.
31. Gairdner, William Tenant. 1862. Public Health in Relation to Air and Water. Edinburgh: Edmonston and Douglas.
32. Galea, Sandro. 2007. Macrosocial Determinants of Population Health. New York: Springer.
33. Galea, Sandro, Matthew Riddle, and George A. Kaplan. 2009. “Causal Thinking and Complex System Approaches in Epidemiology.” Int J Epidemiol39 (1): 97–106.
34. Galea, Sandro, et al. 2011. “Estimated Deaths Attributable to Social Factors in the United States.” Am J Public Health101 (8): 1456–65.
35. Giddens, Anthony. 1979. Central Problems in Social Theory: Action, Structure, and Contradiction in Social Analysis. Berkeley: University of California Press.
36. Giddens, Anthony. 1982. Profiles and Critiques in Social Theory. London: Palgrave Macmillan.
37. Glass, Thomas A., and Matthew J. McAtee. 2006. “Behavioral Science at the Crossroads in Public Health: Extending Horizons, Envisioning the Future.” Soc Sci Med62: 1650–71.
38. Glier, Melissa B., Timothy J. Green, and Angela M. Devlin. 2014. “Methyl Nutrients, DNA Methylation, and Cardiovascular Disease.” Mol Nutr Food Res58 (1): 172–82. doi: 10.1002/mnfr.201200636.
39. Gochfeld, Michael. 2005. “Chronologic History of Occupational Medicine.” J Occup Environ Med47 (2): 96–114.
40. Graham, Hilary, and Michael P. Kelly. 2004. Health Inequalities: Concepts, Frameworks and Policy. London: NHS Health Development Agency. http://www.gserve.nice.org.uk/nicemedia/documents/health_inequalities_concepts.pdf.
41. Heijmans, Bastiaan T., et al. 2008. “Persistent Epigenetic Differences Associated with Prenatal Exposure to Famine in Humans.” Proc Natl Acad Sci USA105 (44): 17046–49.
42. Henderson, Lawrence J. 1935. “Physician and Patient as a Social System.” N Engl J Med212 (18): 819–23.
43. Horton, Richard. 2013. “Non-Communicable Diseases: 2015 to 2025.” Lancet381 (9866): 509–10.
44. Hunter, David John. 2005. “Gene-Environment Interactions in Human Diseases.” Nat Rev Genet6 (4): 287–98.
45. Illari, Phyllis, and Federica Russo. 2013. “Information Channels and Biomarkers of Disease.” Topoi. doi: 10.1007/s11245-013-9228-1.
46. Kandel, Eric R. 1998. “A New Intellectual Framework for Psychiatry.” Am J Psychiatry155 (4): 457–69.
47. Kant, Immanuel. 1781. The Critique of Pure Reason, trans Norman Kemp Smith. Basingstoke: Palgrave Macmillan, 2007.
48. Kelly, Michael P. 2010a. “The Individual and the Social Level in Public Health.” In Evidence- Based Public Health: Effectiveness and Efficiency, ed. Amanda Killoran and Michael P. Kelly, 425–35. Oxford: Oxford University Press. doi: 10.1093/acprof:oso/9780199563623.003.029.
49. Kelly, Michael P. 2010b. “The Axes of Social Differentiation and the Evidence Base on Health Equity.” J R So Med103 (7): 266–72. doi: 10.1258/jrsm.2010.100005.
50. Kelly, Michael P. 2010c. “A Theoretical Model of Assets: The Link Between Biology and the Social Structure.” In Health Assets in a Global Context: Theory, Methods, Action, ed. Antony Morgan, Maggie Davies, and Erio Ziglio, 41–58. New York: Springer.
51. Kelly, Michael P., and Emma Doohan. 2012 “The Social Determinants of Health.” In Global Health: Diseases, Programs, Systems, and Policies, 3rd ed., ed. Michael H. Merson, Robert E. Black, and Anne J. Mills, 75–113. Burlington, MA: Jones and Bartlett.
52. Kelly Michael P., et al. 2009. “A Conceptual Framework for Public Health: NICE’s Emerging Approach.” Public Health123 (1): e14–e20.
53. Krieger, Nancy. 1994. “Epidemiology and the Web of Causation: Has Anyone Seen the Spider?” Soc Sci Med39 (7): 887–903.
54. Krieger, Nancy. 2008a. “Proximal, Distal and the Politics of Causation: What’s Level Got to Do with It?” Am J Public Health98 (2): 221–30.
55. Krieger, Nancy. 2008b. “Ladders, Pyramids, and Champagne: The Iconography of Health Inequities.” J Epidemiol Community Health62 (12): 1098–104.
56. Lazarus, Richard S., and Susan Folkman. 1984. Stress, Appraisal and Coping. New York: Springer. Levine, Ruth, and the What Works Working Group. 2004. Millions Saved: Proven Successes in Global Health. Washington, DC: Center for Global Development.
57. Link, Bruce G., and Jo Phelan. 1995. “Social Conditions as Fundamental Causes of Disease.” J Health Soc Behav(special issue): 80–94.
58. Link, Bruce G., and Jo Phelan. 2000. “Evaluating the Fundamental Cause Explanation for Social Disparities in Health.” In The Handbook of Medical Sociology, 5th ed., ed. Chloe Bird, Peter Conrad, and Allen Fremont, 33–46. New York: Prentice Hall.
59. Lozano, Rafael, et al. 2012. “Global and Regional Mortality from 235 Causes of Death for 20 Age Groups in 1990 and 2010: A Systematic Analysis for the Global Burden of Disease Study 2010.” Lancet380 (9859): 2095–128.
60. McGuinness, Dagmara, et al. 2012. “Socio-Economic Status Is Associated with Epigenetic Differences in the pSoBid Cohort.” Int J Epidemiol41 (1): 151–60.
61. Mackenbach, J. P. 2009. “Politics Is Nothing but Medicine at a Larger Scale: Reflections on Public Health’s Biggest Idea.” J Epidemiol Community Health63: 181–84.
62. Mackenbach, J. P. 2012. “The Persistence of Health Inequalities in Modern Welfare States: The Explanation of a Paradox.” Soc Sci Med75 (4): 761–69.
63. Marmot, Michael. 2010a. Fair Society, Healthy Lives: Strategic Review of Health Inequalities in England Post 2010. London: UCL. http://www.ucl.ac.uk/gheg/marmotreview/Documents/finalreport.
64. Marmot, Michael. 2010b. Interim First Report on Social Determinants of Health and the Health Divide in the WHO European Region. Executive Summary: European Social Determinants and Health Divide Review. London: UCL/Copenhagen: WHO Regional Office for Europe. http://www.euro.who.int/__data/assets/pdf_file/0003/124464/E94370.pdf.
65. Marmot, Michael. 2008. “Global Health Equity: Evidence for Action on the Social Determinants of Health.” J Epidemiol Community Health62 (12): 1095–97.
66. Marmot, Michael, and R. Bell. 2009. “Action on Health Disparities in the United States: Commission on the Social Determinants of Health.” JAMA301 (11): 1169–71.
67. Marmot, Michael, and Richard G. Wilkinson. 2005. Social Determinants of Health, 2nd ed. Oxford: Oxford University Press.
68. Marteau, Theresa M., and Peter A. Hall. 2013. “Breadlines, Brains, and Behaviour.” BMJ347: f6750. doi: 10.1136/bmj.f6750.
69. Marteau, Theresa M., Gareth J. Hollands, and Paul C. Fletcher. 2012. “Changing Human Behavior to Prevent Disease: The Importance of Targeting Automatic Processes.” Science337 (6101): 1492–95. doi: 10.1126/science.1226918.
70. Meads, Catherine, Chris Carmona, and Michael P. Kelly. 2012. “Lesbian, Gay and Bisexual People’s Health in the UK: A Theoretical Critique and Systematic Review.” Diversity Equality Health Care9 (1): 19–32.
71. Meloni, Maurizio. 2014. “Biology Without Biologism: Social Theory in a Postgenomic Age.” Sociology48 (4): 731–46.
72. Moffitt, Terrie E., et al. 2011. “A Gradient of Childhood Self-Control Predicts Health, Wealth, and Public Safety.” Proc Natl Acad Sci USA108 (7): 2693–99. doi: 10.1073/pnas.1010076108.
73. Ottman, Ruth. 1996. “Gene-Environment Interaction: Definitions and Study Designs.” Prev Med25 (6): 764–70.
74. Packard, Chris, et al. 2011. “Early Life Socioeconomic Adversity Is Associated in Adult Life with Chronic Inflammation, Carotid Atherosclerosis, Poorer Lung Function and Decreased Cognitive Performance: A Cross-Sectional, Population-Based Study.” BMC Public Health11: 42.
75. Paneth, Nigel. 2004. “Assessing the Contribution of John Snow to Epidemiology.” Epidemiology15 (5): 514–16.
76. Parsons, Talcott. 1951. The Social System. London: Routledge and Kegan Paul.
77. Phelan, Jo, et al. 2004. “‘Fundamental Causes’ of Social Inequalities in Mortality: A Test of the Theory.” J Health Soc Behav45 (3): 265–85.
78. Pridan, Daniel. 1964. “Rudolf Virchow and Social Medicine in Historical Perspective.” Med History8 (3): 274–78.
79. Raver, C. Cybele, Clancy Blair, and Michael Willoughby. 2013. “Poverty as a Predictor of 4-Year-Olds’ Executive Function: New Perspectives on Models of Differential Susceptibility.” Dev Psychol49 (2): 292–304. doi: 10.1037/a0028343.
80. Relton, Caroline L., and George Davey Smith. 2012. “Is Epidemiology Ready for Epigenetics?” Int J Epidemiol41 (1): 5–9.
81. Rose, Geoffrey. 1990. “Preventive Cardiology: What Lies Ahead?” Prevent Med19 (1): 97–104.
82. Rose Geoffrey. 2008. Rose’s Strategy of Preventive Medicine. Oxford: Oxford University Press.
83. Russo, Federica. 2009. Causality and Causal Modelling in the Social Sciences: Measuring Variations. New York: Springer.
84. Russo, Federica. 2011. “Causal Webs in Epidemiology.” Paradigmi39: 67–98.
85. Russo, Federica, and Jon Williamson. 2007. “Interpreting Causality in the Health Sciences.” Int Stud Philos Sci21 (2): 157–70.
86. Russo, Federica, and Jon Williamson. 2011. “Epistemic Causality and Evidence-Based Medicine.” Hist Philos Life Sci33 (14): 563–81.
87. Schutz, Alfred. 1967. The Phenomenology of the Social World, trans G. Walsh and F. Lehnert. Evanston: Northwestern University Press.
88. Schutz, Alfred. 1970. On Phenomenology and Social Relations: Selected Writings, trans H. R. Wagner. Chicago: University of Chicago Press.
89. Sen, Amartya. 2009. The Idea of Justice. London: Allen Lane.
90. Solar, Orielle, and Alec Irwin. 2007. “Towards a Conceptual Framework for Analysis and Action on the Social Determinants of Health.” Geneva: WHO/Commission on Social Determinants of Health.
91. Spitz, Margaret R., and Melissa L. Bondy. 2010. “The Evolving Discipline of Molecular Epidemiology of Cancer.” Carcinogenesis31 (1): 127–34.
92. Starfield, Barbara. 2006. “State of the Art in Research on Equity and Health.” J Health Polit Policy Law31 (1): 11–32.
93. Starfield, Barbara. 2007. “Pathways of Influence on Equity in Health.” Soc Sci Med64 (7): 1355–62.
94. Strack, Fritz, and Roland Deutsch. 2004. “Reflective and Impulsive Determinants of Social Behavior.” Pers Soc Psychol Rev8 (3): 220–47.
95. Susser, Mervyn, and Ezra Susser. 1996. “Choosing a Future for Epidemiology: II. From Black Box to Chinese Boxes and Eco-Epidemiology.” Am J Public Health86 (5): 674–77.
96. Thayer, Zaneta M., and Chris W. Kuzawa. 2011. “Biological Memories of Past Environments: Epigenetic Pathways to Health Disparities.” Epigenetics6 (7): 798–803.
97. Thisted, Ronald A. 2003. “Are There Social Determinants of Health and Disease?” Perspect Biol Med46 (suppl. 3): S65–S73.
98. Taylor, Shelley E., Rena L. Repetti, and Teresa Seeman. 1997. “Health Psychology: What Is an Unhealthy Environment and How Does It Get Under the Skin?” Annu Rev Psychol48: 411–47.
99. United Nations (UN) General Assembly. 2011. Political Declaration of the High-Level Meeting of the General Assembly on the Prevention and Control of Non-Communicable Diseases. General Assembly Sixty-Sixth Session. New York: UN. http://www.un.org/en/ga/president/66/Issues/NCD/ncdindex.shtml.
100. Verma, Mukesh, Muin J. Khoury, and John P. A. Ioannidis. 2013. “Opportunities and Challenges for Selected Emerging Technologies in Cancer Epidemiology: Mitochondrial, Epigenomic, Metabolomic, and Telomerase Profiling.” Cancer Epidemiol Biomarkers Prev22 (2): 189–200.
101. Vineis, Paolo, and David Kriebel. 2006. “Causal Models in Epidemiology: Past Inheritance and Genetic Future.” Environ Health5: 21.
102. Vineis, Paolo, Silvia Stringhini, and Miguel Porta. 2014. “The Environmental Roots of Non-Communicable Diseases (NCDs) and the Epigenetic Impacts of Globalization.” Environ Res133: 424–30. doi: 10.1016/j.envres.2014.02.002.
103. Webster, Charles. 1990. The Victorian Public Health Legacy: A Challenge to the Future. London: Institution of Environmental Health Officers/Public Health Alliance.
104. World Health Organization (WHO). 2012. Action Plan for Implementation of the European Strategy for the Prevention and Control of Noncommunicable Diseases 2012–2016. Copenhagen: WHO Regional Office for Europe. http://www.euro.who.int/__data/assets/pdf_file/0019/170155/e96638.pdf?ua=1.