Mechanism of curcumin analog MHMD-induced cell death in A549 lung cancer cells

European Review for Medical and Pharmacological Sciences

Volumn 18, Issue 20, 2014, Pages 3134-3138

  Zhou, G Z ^a   Cao, F K ^a   Chang, J M ^b   Sun, G C ^a   Chen, X B ^c  

^a HENAN UNIVERSITY OF TECHNOLOGY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c ZHENGZHOU UNIVERSITY   (China)

Author keywords

Anticancer; Apoptosis; Curcumin analog; Necrosis

Indexed keywords

ACRIDINE ORANGE; CURCUMIN;

A549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BINDING AFFINITY; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE MICROSCOPE; IC50; LUNG CANCER; LYSOSOME; MTT ASSAY; NECROSIS; NUCLEOLUS; STAINING; ANALOGS AND DERIVATIVES; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; HUMAN; LUNG NEOPLASMS; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LUNG NEOPLASMS;

EID: 84928953401     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. RAVINDRAN J, PRASAD S, AGGARWAL BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J 2009; 11: 495-510.
2. VIOLA G, BORTOLOZZI R, HAMEL E, MORO S, BRUN P, CASTAGLIUOLO I, FERLIN MG, BASSO G. MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol 2012; 83: 16-26.
3. SHINOJIMA N, YOKOYAMA T, KONDO S, KONDO Y. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 2007; 3: 635-637.
4. ) THOMAS SL, ZHONG D, ZHOU W, MALIK S, LIOTTA D, SNYDER JP, HAMEL E, GIANNAKAKOU P. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle 2008; 7: 2409-2417.
5. SATO A, KUDO C, YAMAKOSHI H, UEHARA Y, OHORI H, ISHIOKA C, IWABUCHI Y, SHIBATA H. Curcumin analog GO-Y030 is a novel inhibitor of IKKbeta that suppresses NF-kappaB signaling and induces apopt osis. Cancer Sci 2011; 102: 1045-1051.
6. KANWAR SS, YU Y, NAUTIYAL J, PATEL BB, PADHYE S, SARKAR FH, MAJUMDAR AP. Difluorinated-curcumin (CDF): a novel curcumin analog is a potent i nhibitor of colon cancer stem-like cells. Pharm Res 2011; 28: 827-838.
7. FAIAO-FLORES F,SUAREZ JA,PARDI PC,MARIA DA. DM-1, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate: a curcumin analog with a synergic effect in combination with paclitaxel in breast cancer treatment. Tumour Biol 2012 33 775-785.
8. SHIBATA H, YAMAKOSHI H, SATO A, OHORI H, KA KUDO Y, KUDO C, TAKAHASHI Y, WATANABE M, TAKANO H, ISHIOKA C, NODA T, IWABUCHI Y. Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo. Cancer Sci 2009; 100: 956-960.
9. MUKHOPADHYAY A, BANERJEE S, STAFFORD LJ, XIA C, LIU M, AGGARWAL BB. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediate d retinoblastoma protein phosphorylation. Oncogene 2002; 21: 8852-8861.
10. O'SULLIVAN-COYNE G, O'SULLIVAN GC, O'DONOVAN TR, PIWOCKA K, MCKENNA SL. Curcumin induces apoptosis-independent deat h in oesophageal cancer cells. Br J Cancer 2009; 101: 1585-1595.
11. HANAHAN D, WEINBERG RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.