Analysis of cerebral lobar microbleeds and a decreased cerebral blood flow in a memory clinic setting

Internal Medicine

Volumn 54, Issue 9, 2015, Pages 1027-1033

  Doi, Hikaru ^a   Inamizu, Saeko ^b   Saito, Ban Yu ^a   Murai, Hiroyuki ^b   Araki, Takehisa ^a   Kira, Jun Ichi ^b  

^a ATOMIC BOMB SURVIVORS HOSPITAL   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Alzheimer s disease; Cerebral blood flow; Cerebral microbleeds; Dementia with Lewy bodies; ECD SPECT

Indexed keywords

AGE; AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; FRONTAL LOBE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; PARIETAL LOBE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ALZHEIMER DISEASE; ANALOGS AND DERIVATIVES; BRAIN CIRCULATION; COGNITIVE DEFECT; COMPLICATION; DIAGNOSTIC USE; JAPAN; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; REPRODUCIBILITY; SCINTISCANNING; VERY ELDERLY;

CYSTEINE; CYSTEINE ETHYL ESTER TC 99M; TECHNETIUM COMPLEX;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; CYSTEINE; FEMALE; FRONTAL LOBE; HUMANS; INTRACRANIAL HEMORRHAGES; JAPAN; MAGNETIC RESONANCE IMAGING; MALE; ORGANOTECHNETIUM COMPOUNDS; REPRODUCIBILITY OF RESULTS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84928948177     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.54.3747     Document Type: Article

References (31)

1. Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 12: 822-828, 2013.
2. Charidimou A, Krishnan A, Werring DJ, Rolf Jäger H. Cerebral microbleeds: a guide to detection and clinical relevance in different disease settings. Neuroradiology 55: 655-674, 2010.
3. Pantoni L. Cerebral small vessel disease from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9: 689-701, 2010.
4. Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosug Psychiatry 82: 124-137, 2012.
5. Jellinger KA. Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm 109: 813-836, 2012.
6. Kalaria RN, Ballard C. Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord 13 (Suppl 3): 115-123, 1999.
7. Tanskanen M, Lindsberg PJ, Tienari PJ, et al. Cerebral amyloid angiopathy in a 95+ cohort: complement activation and apolipoprotein E (ApoE) genotype. Neuropathol Appl Neurobiol 31: 589-599, 2005.
8. Cordonnier C, van der Flier WM. Brain microbleeds and Alzheimer’s disease: innocent observation or key player? Brain 134: 335-344, 2011.
9. Pettersen JA, Sathiyamoorthy G, Gao FQ, et al. Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol 65: 790-795, 2008.
10. Rosand J, Muzikansky A, Kumar A, et al. Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 58: 459-462, 2005.
11. Poels MM, Ikram MA, van der Lugt A, et al. Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology 78: 326-333, 2012.
12. van Norden AG, van den Berg HA, de Laat KF, et al. Frontal and temporal microbleeds are related to cognitive function: the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study. Brain 42: 3382-3386, 2011.
13. van der Vlies AE, Goos JD, Barkhof F, et al. MBs do not affect rate of cognitive decline in Alzheimer disease. Neurology 79: 763-769, 2012.
14. van Es AC, van der Grond J, de Craen AJ, et al. Cerebral microbleeds and cognitive functioning in the PROSPER study. Neurology 77: 1446-1452, 2011.
15. Lei C, Lin S, Tao W, et al. Association between cerebral microbleeds and cognitive function: a systematic review. J Neurol Neurosurg Psychiatry 84: 693-697, 2013.
16. Goos JD, Kester MI, Barkhof F, et al. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke 40: 3455-3460, 2009.
17. McKhann GM, Knipman DS, Chertkov H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7: 263-269, 2011.
18. Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7: 270-279, 2011.
19. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65: 1863-1872, 2011.
20. Matsuda H, Mizumura S, Nemoto K, et al. Automatic voxel-based morphometry of structural MRI by SPM8 plus diffeomorphic anatomic registration through exponentiated lie algebra improves the diagnosis of probable Alzheimer Disease. AJNR Am J Neuroradiol 33: 1109-1114, 2012.
21. Matsuda H, Mizumura S, Nagao T, et al. Automated discrimination between very early Alzheimer disease and controls using an easy Z-score imaging system for multicenter brain perfusion single-photon emission tomography. Am J Neuroradiol 28: 731-736, 2007.
22. Mesker DJ, Poels MM, Ikram MA, et al. Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study. Arch Neurol 68: 656-659, 2011.
23. Williams O, Brust JC. Hypertensive encephalopathy. Curr Treat Options Cardiovasc Med 6: 209-216, 2004.
24. Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. Am J Neuroradiol 20: 637-642, 1999.
25. Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol 55: 306-319, 2004.
26. Price JC, Klunk WE, Lopresti BJ, et al. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 25: 1528-1547, 2005.
27. Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease. Brain 131: 1630-1645, 2008.
28. Johnson KA, Jones K, Holman BL, et al. Preclinical prediction of Alzheimer’s disease using SPECT. Neurology 50: 1563-1571, 1998.
29. Kogure D, Matsuda H, Ohnishi T, et al. Longitudinal evaluation of early Alzheimer’s disease using brain perfusion SPECT. J Nucl Med 41: 1155-1162, 2000.
30. Fukui T, Oowan Y, Yamazaki T, Kinno R. Prevalence and clinical implication of microbleeds in dementia with lewy bodies in comparison with microbleeds in Alzheimer’s disease. Dement Geriatr Cogn Disord Extra 3: 148-160, 2013.
31. Staekenborg SS, Koedam EL, Henneman WJ, et al. Progression of mild cognitive impairment to dementia: contribution of cerebrovascular disease compared with medial temporal lobe atrophy. Stroke 40: 1269-1274, 2009.