Recent HIV-1 outbreak among intravenous drug users in Romania: Evidence for cocirculation of CRF14-BG and Subtype F1 Strains

AIDS Research and Human Retroviruses

Volumn 31, Issue 5, 2015, Pages 488-495

  Niculescu, Iulia ^a   Paraschiv, Simona ^a   Paraskevis, Dimitrios ^b   Abagiu, Adrian ^a   Batan, Ionelia ^a   Banica, Leontina ^a   Otelea, Dan ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Romania)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; DIAMORPHINE; PSYCHOSTIMULANT AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EPIDEMIOLOGICAL DATA; FEMALE; HEPATITIS C VIRUS; HIGH RISK POPULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; INTRAVENOUS DRUG ABUSE; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MOLECULAR PHYLOGENY; PRIORITY JOURNAL; ROMANIA; SEXUALLY TRANSMITTED DISEASE; TROPISM; VIROTHERAPY; VIRUS STRAIN; CLASSIFICATION; CLUSTER ANALYSIS; COMPLICATION; DNA SEQUENCE; DRUG USE; EPIDEMIC; GENETICS; GENOTYPE; HEPATITIS C; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOLECULAR GENETICS; PHYLOGENY; PREVALENCE; SUBSTANCE ABUSE; TRANSMISSION; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CLUSTER ANALYSIS; CROSS-SECTIONAL STUDIES; DISEASE OUTBREAKS; DRUG USERS; FEMALE; GENOTYPE; HEPATITIS C; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOLECULAR SEQUENCE DATA; PHYLOGENY; PREVALENCE; ROMANIA; SEQUENCE ANALYSIS, DNA; SUBSTANCE ABUSE, INTRAVENOUS; YOUNG ADULT;

EID: 84928940877     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2014.0189     Document Type: Article

References (37)

1. HIV/AIDS Surveillance in Europe 2012, p. 7, available at www.ecdc.europa.eu/en/publications/Publications/hiv-Aidssurveillance-report-2012-20131127.pdf. Accessed June 6, 2014.
2. Mathers BM, Degenhardt L, Phillips B, Wiessing L, et al.: Global epidemiology of injecting drug use and HIV among people who inject drugs: A systematic review. Lancet 2008;15:372(9651):1733-1745.
3. Mathers BM, Degenhardt L, Bucello C, Lemon J, Wiessing L, and Hickman M: Mortality among people who inject drugs: A systematic review and meta-Analysis. Bull World Health Organ 2013;91(2):102-123.
4. Hersh BS, Popovici, F, Jezek, et al.: Risk factors for HIV infection among abandoned Romanian children. AIDS 1993;7(12):1617-1624.
5. Romanian HIV/AIDS National Committee Report, 2013, p. 4, available at www.cnlas.ro/images/doc/rom-30-iunie2013eng.pdf. Accessed June 6, 2014.
6. Guimarães ML, Vicente AC, Otsuki K, et al.: Close phylogenetic relationship between Angolan and Romanian HIV-1 subtype F1 isolates. Retrovirology 2009;22(6):39.
7. Mehta SR, Wertheim JO, Delport W, et al.: Using phylogeography to characterize the origins of the HIV-1 subtype F epidemic in Romania. Infect Genet Evol 2011;11(5): 975-979.
8. Florea D, Paraschiv S, Fratila M, and Otelea D: Human immunodeficiency virus F1 subtype is associated with late presentation in newly diagnosed Romanian patients. Clin Microbiol Infect 2010;Supp 1:abstract 1213.
9. Romanian HIV/AIDS National Committee Report, 2013, p. 17, available at www.cnlas.ro/images/doc/rom-31122013 .pdf. Accessed June 6, 2014.
10. Botescu A: Risk assessment of new psychoactive substances consumption among children and youth in Romania, 2012, pp. 16-18, available at www.rhrn.ro/public/uploads/file/227/risk-Assessment-of-new-psychoactive-substancesconsumption-Among-children-And-youth-in-romania.pdf. Accessed February 4, 2014.
11. 2012 National Report (2011 data) to the EMCCDDA by the Reitox National Focus Point, Romania: New Developments, trends and in-depth information on selected issues, pp. 52-53, available at www.ana.gov.ro/rapoarte%20nationale/en/National%20Report%20on%20Drugs%202012.pdf.
12. Romanian HIV/AIDS National Committee Report, 2013, p. 23, available at www.cnlas.ro/images/doc/rom-31122013 .pdf. Accessed June 6, 2014.
13. REGA HIV-1&2 automated subtyping tool version 2.0 available at http://jose.med.kuleuven.be/genotypetool/html/indexhiv.html.
14. SimPlot v3.5.1 software available at http://sray.med.som .jhmi.edu/SCRoftware/simplot/.
15. Hypermut 2.0-Analysis & Detection of APOBEC-induced Hypermutation, available at www.hiv.lanl.gov/content/sequence/HYPERMUT/hypermut.html.
16. Demetriou VL, van de Vijver DA, Kousiappa I, Balotta C, Clotet B, and Grossman Z: Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe. PLoS One 2010;5(6):e10976.
17. Lengauer T, Sander O, Sierra S, Thielen A, and Kaiser R: Bioinformatics prediction of HIV coreceptor usage. Nat Biotechnol 2007;25(12):1407-1410.
18. Vandekerckhove LP, Wensing AM, Kaiser R, et al.: European Consensus Group on clinical management of tropism testing. Lancet Infect Dis 2011;11(5):394-407.
19. Swofford DL: PAUP. Phylogenetic Analysis Using Parsimony (and Other Methods), Version 4. Sinauer Associates, Sunderland, MA, 1998.
20. FigTree software version 1.2.3 available at http://tree.bio .ed.ac.uk/software/figtree/.
21. Drummond AJ, Suchard MA, Xie D, and Rambaut A: Bayesian phylogenetics with BEAUti and the BEAST 1.7 Mol Biol Evol 2012;29:1969-1973.
22. Tracer software v1.4 available at http://tree.bio.ed.ac.uk/software/tracer/.
23. Salminen M: Letter to the editor: HIV-1 outbreak among injecting drug users in Greece, 2011: A preliminary report. Eurosurveillance 2011;16(41), available atwww.eurosurveillance.org/ViewArticle.aspx?ArticleId=19986.Accessed February 4, 2014.
24. EMCDDA: News updates 2012-Outbreaks of HIV among IDUs in Greece and Romania: Preliminary data suggest no signs of a slowing down in 2012. www.emcdda.europa.eu/news/2012/HIV-outbreaks. Accessed June 6, 2014.
25. Botescu A, Abagiu A, Mardarescu M, and Ursan M: HIV/AIDS among injecting drug users in Romania. Report of a recent outbreak and initial response policies, 2012, pp. 5-14 available at www.emcdda.europa.eu/attachements.cfm/att-192024-EN-HIV-outbreak-Romania-2012.pdf. Accessed February 4, 2014.
26. Vickerman P, Hickman M, May M, Kretzschmar M, and Wiessing L: Can hepatitis C virus prevalence be used as a measure of injection-related human immunodeficiency virus risk in populations of injecting drug users? An ecological analysis. Addiction 2009;105(2):311-318.
27. Kwon JA, Iversen J, Maher L, Law MG, and Wilson DP: The impact of needle and syringe programs on HIV and HCV transmissions in injecting drug users in Australia: A model-based analysis. J Acquir Immune Defic Syndr 2009;51:462-469.
28. Paraskevis D, Nikolopoulos G, et al.: Economic recession and emergence of an HIV-1 outbreak among drug injectors in Athens metropolitan area: A longitudinal study. PLoS One 2013;8(11):e78941.
29. Bártolo I, Abecasis AB, Borrego P, et al.: Origin and epidemiological history of HIV-1 CRF14-BG. PLoS One 2011;6(9):e24130.
30. Pérez-Á lvarez L, Delgado E, Vega Y, et al.: Predominance of CXCR4 tropism in HIV-1 CRF14-BG strains from newly diagnosed infections. J Antimicrob Chemother 2014;69(1):246-253.
31. Romanian HIV/AIDS National Committee Report, 2013, p. 36, available at http://cnlas.ro/images/doc/rom-31122013en .pdf. Accessed June 6, 2014.
32. Abagiu A and Botescu A: Update on country situation: Romania; 2nd meeting on detecting and responding to outbreaks of HIV among IDUs, 2012, p. 11, available at www.emcdda.europa.eu/attachements.cfm/att-195213-EN-02%20Romania.pdf. Accessed February 4, 2014.
33. European Monitoring Centre for Drugs and Drug Addiction, National Anti-drug Agency, 2013 NATIONAL REPORT (2012 data) TO THE EMCDDA by the Reitox National Focal Point National Report on drug situation in Romania, p. 45, available at www.ana.gov.ro/rapoarte% 20nationale/en/National%20Report%20on%20Drugs%202013 .pdf. Accessed June 10, 2014.
34. Stanojevic M, Alexiev I, Beshkov D, et al.: HIV-1 molecular epidemiology in the Balkans: A melting pot for high genetic diversity. AIDS Rev 2012;14(1):28-36.
35. Paraschiv S, Otelea D, Batan I, Baicus C, Magiorkinis G, and Paraskevis D: Molecular typing of the recently expanding subtype B HIV-1 epidemic in Romania: Evidence for local spread among MSMs in Bucharest area. Infect Genet Evol 2012;12(5):1052-1057.
36. Paraschiv S, Batan I, Banica L, et al.: Recombination analysis for subtyping unclassified HIV-1 isolates in Romania. Ther Pharmacol Clin Toxicol 2012;XVI(3):163-167.
37. Cuevas MT, Fernandez-Garcia A, Pinilla M, et al.: Short communication: Biological and genetic characterization of HIV type 1 subtype B and nonsubtype B transmitted viruses: Usefulness for vaccine candidate assessment. AIDS Res Hum Retroviruses 2010;26:1019-1025.