Lesion load may predict long-term cognitive dysfunction in multiple sclerosis patients

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Patti, Francesco ^a   De Stefano, Manuela ^b   Lavorgna, Luigi ^b   Messina, Silvia ^a   Chisari, Clara Grazia ^a   Ippolito, Domenico ^b   Lanzillo, Roberta ^c   Vacchiano, Veria ^c   Realmuto, Sabrina ^d   Valentino, Paola ^e   Coniglio, Gabriella ^f   Buccafusca, Maria ^g   Paolicelli, Damiano ^h   D'Ambrosio, Alessandro ^b   Montella, Patrizia ^b   Morra, Vincenzo Brescia ^c   Savettieri, Giovanni ^d   Alfano, Bruno ⁱ   Gallo, Antonio ^b   Simone, Isabella ^h   Viterbo, Rosa ^h   Zappia, Mario ^a   Bonavita, Simona ^b,j   Tedeschi, Gioacchino ^b   more..

^a UNIVERSITY OF CATANIA   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF PALERMO   (Italy)

^e UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^f MADONNA DELLE GRAZIE HOSPITAL   (Italy)

^g UNIVERSITY OF MESSINA   (Italy)

^h UNIVERSITY OF BARI   (Italy)

ⁱ CNR   (Italy)

^j Neurological Institute for Diagnosis and Care Hermitage Capodimonte   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATTENTION; BRAIN SIZE; CEREBROSPINAL FLUID; COGNITIVE DEFECT; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; GRAY MATTER; HUMAN; MAJOR CLINICAL STUDY; MALE; MODIFIED CARD SORTING TEST; MULTIPLE SCLEROSIS; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PACED AUDITORY SERIAL ADDITION TEST; PREDICTIVE VALUE; RECALL; SEMANTICALLY RELATED WORD LIST TEST; SYMBOL DIGIT MODALITIES TEST; VERBAL MEMORY; WHITE MATTER; WORKING MEMORY; ADULT; BRAIN; COGNITION DISORDERS; COHORT ANALYSIS; COMPLICATION; DISEASE COURSE; FOLLOW UP; MIDDLE AGED; MYELINATED NERVE; PATHOLOGY; PROGNOSIS; SHORT TERM MEMORY;

ADULT; BRAIN; COGNITION DISORDERS; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GRAY MATTER; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE FIBERS, MYELINATED; NEUROPSYCHOLOGICAL TESTS; PROGNOSIS;

EID: 84928892304     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120754     Document Type: Article

References (38)

1. Patti F. Cognitive impairment in multiple sclerosis. Mult Scler. 2009;15(1):2-8. doi: 10.1177/1352458508096684 PMID: 18805842
2. Pirko I, Lucchinetti CF, Sriram S, Bakshi R. Gray matter involvement in multiple sclerosis. Neurology. 2007;68(9):634-42. PMID: 17325269
3. Morgen K, Sammer G, Courtney SM, Wolters T, Melchior H, Blecker CR, et al. Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS. NeuroImage. 2006;30(3):891-8. PMID: 16360321
4. Deloire MS, Ruet A, Hamel D, Bonnet M, Dousset V, Brochet B. MRI predictors of cognitive outcome in early multiple sclerosis. Neurology. 2011;76(13):1161-7. doi: 10.1212/WNL.0b013e318212a8be PMID: 21444901
5. Summers M, Fisniku L, Anderson V, Miller D, Cipolotti L, Ron M. Cognitive impairment in relapsing-remitting multiple sclerosis can be predicted by imaging performed several years earlier. Mult Scler. 2008;14(2):197-204. PMID: 17986503
6. Fulton JC, Grossman RI, Udupa J, Mannon LJ, Grossman M, Wei L, et al. MR lesion load and cognitive function in patients with relapsing-remitting multiple sclerosis. AJNR Am J Neuroradiol. 1999;20(10):1951-5. PMID: 10588124
7. Rovaris M, Comi G, Filippi M. MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction. J Neurol Sci. 2006;245(1-2):111-6. PMID: 16674978
8. Zivadinov R, Sepcic J, Nasuelli D, De Masi R, Bragadin LM, Tommasi MA, et al. A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry. 2001;70(6):773-80. PMID: 11385012
9. Alfano B, Brunetti A, Larobina M, Quarantelli M, Tedeschi E, Ciarmiello A, et al. Automated segmentation and measurement of global white matter lesion volume in patients with multiple sclerosis. Journal of magnetic resonance imaging: JMRI. 2000;12(6):799-807. PMID: 11105017
10. Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, et al. Brain atrophy and lesion load in a large population of patients with multiple sclerosis. Neurology. 2005;65(2):280-5. PMID: 16043800
11. Lavorgna L, Bonavita S, Ippolito D, Lanzillo R, Salemi G, Patti F, et al. Clinical and magnetic resonance imaging predictors of disease progression in multiple sclerosis: a nine-year follow-up study. Mult Scler. 2013.
12. Prinster A, Quarantelli M, Orefice G, Lanzillo R, Brunetti A, Mollica C, et al. Grey matter loss in relapsingremitting multiple sclerosis: a voxel-based morphometry study. Neuroimage. 2006;29(3):859-67. PMID: 16203159
13. Smith A. Symbol digit modalities test1991.
14. Mauri M. Archivio di Psicologia, Neurologia e Psichiatria. 1997;58(5-6):621-45.
15. Nelson HE. A modified card sorting test sensitive to frontal lobe defects. Cortex. 1976;12(4):313-24. PMID: 1009768
16. Gronwall DM. Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills. 1977;44(2):367-73. PMID: 866038
17. Amato MP, Portaccio E, Goretti B, Zipoli V, Ricchiuti L, De Caro MF, et al. The Rao's Brief Repeatable Battery and Stroop Test: normative values with age, education and gender corrections in an Italian population. Mult Scler. 2006;12(6):787-93. PMID: 17263008
18. Nocentini U, Di Vincenzo S, Panella P, Pasqualetti P, Caltagirone C. La valutazione delle funzioni esecutive nella pratica neuropsicologica: dal Modified Card Sorting Test al Modified Card Sorting Test-Roma version. Dati di standardizzazione. NUOVA RIVISTA DI NEUROLOGIA. 2002.
19. Camp SJ, Stevenson VL, Thompson AJ, Miller DH, Borras C, Auriacombe S, et al. Cognitive function in primary progressive and transitional progressive multiple sclerosis: a controlled study with MRI correlates. Brain. 1999;122(Pt 7):1341-8. PMID: 10388799
20. Benedict RH, Weinstock-Guttman B, Fishman I, Sharma J, Tjoa CW, Bakshi R. Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden. Arch Neurol. 2004;61(2):226-30. PMID: 14967771
21. Benedict RH, Bruce JM, Dwyer MG, Abdelrahman N, Hussein S, Weinstock-Guttman B, et al. Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis. Arch Neurol. 2006;63(9):1301-6. PMID: 16966509
22. Amato MP, Portaccio E, Goretti B, Zipoli V, Battaglini M, Bartolozzi ML, et al. Association of neocortical volume changes with cognitive deterioration in relapsing-remitting multiple sclerosis. Arch Neurol. 2007;64(8):1157-61. PMID: 17698706
23. Papadopoulou A, Muller-Lenke N, Naegelin Y, Kalt G, Bendfeldt K, Kuster P, et al. Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis. Mult Scler. 2013.
24. Bendfeldt K, Blumhagen JO, Egger H, Loetscher P, Denier N, Kuster P, et al. Spatiotemporal distribution pattern of white matter lesion volumes and their association with regional grey matter volume reductions in relapsing-remitting multiple sclerosis. Hum Brain Mapp. 2010;31(10):1542-55. doi: 10. 1002/hbm.20951 PMID: 20108225
25. Tozer DJ, Chard DT, Bodini B, Ciccarelli O, Miller DH, Thompson AJ, et al. Linking white matter tracts to associated cortical grey matter: a tract extension methodology. Neuroimage. 2012;59(4):3094-102. doi: 10.1016/j.neuroimage.2011.10.088 PMID: 22100664
26. Leone C, Patti F, Feys P. Measuring the cost of cognitive-motor dual tasking during walking in multiple sclerosis. Mult Scler. 2014.
27. Wills S, Leathem J. The effects of test anxiety, age, intelligence level, and arithmetic ability on Paced Auditory Serial Addition Test performance. Appl Neuropsychol. 2004;11(4):180-7. PMID: 15673489
28. Parmenter BA, Zivadinov R, Kerenyi L, Gavett R, Weinstock-Guttman B, Dwyer MG, et al. Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis. J Clin Exp Neuropsychol. 2007;29(2):215-23. PMID: 17365256
29. Ruet A, Deloire M, Charre-Morin J, Hamel D, Brochet B. Cognitive impairment differs between primary progressive and relapsing-remitting MS. Neurology. 2013;80(16):1501-8. doi: 10.1212/WNL. 0b013e31828cf82f PMID: 23516324
30. Amato MP, Bartolozzi ML, Zipoli V, Portaccio E, Mortilla M, Guidi L, et al. Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment. Neurology. 2004;63(1):89-93. PMID: 15249616
31. Guimaraes J, Sa MJ. Cognitive dysfunction in multiple sclerosis. Front Neurol. 2012;3:74. doi: 10. 3389/fneur.2012.00074 PMID: 22654782
32. Amato MP, Portaccio E, Stromillo ML, Goretti B, Zipoli V, Siracusa G, et al. Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosis. Neurology. 2008;71(9):632-8. doi: 10.1212/01.wnl.0000324621.58447.00 PMID: 18725589
33. Bastianello S, Giugni E, Amato MP, Tola MR, Trojano M, Galletti S, et al. Changes in magnetic resonance imaging disease measures over 3 years in mildly disabled patients with relapsing-remitting multiple sclerosis receiving interferon beta-1a in the COGnitive Impairment in MUltiple Sclerosis (COGIMUS) study. BMC neurology. 2011;11(1):125.
34. Patti F, Amato MP, Trojano M, Bastianello S, Tola MR, Goretti B, et al. Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study. Mult Scler. 2009;15(7):779-88. doi: 10.1177/1352458509105544 PMID: 19542262
35. Bomboi G, Ikonomidou VN, Pellegrini S, Stern SK, Gallo A, Auh S, et al. Quality and quantity of diffuse and focal white matter disease and cognitive disability of patients with multiple sclerosis. J Neuroimaging. 2011;21(2):e57-63. doi: 10.1111/j.1552-6569.2010.00488.x PMID: 20626570
36. Tiberio M, Chard DT, Altmann DR, Davies G, Griffin CM, Rashid W, et al. Gray and white matter volume changes in early RRMS: a 2-year longitudinal study. Neurology. 2005;64(6):1001-7. PMID: 15781816
37. Filippi M, Preziosa P, Copetti M, Riccitelli G, Horsfield MA, Martinelli V, et al. Gray matter damage predicts the accumulation of disability 13 years later in MS. Neurology. 2013;81(20):1759-67. doi: 10. 1212/01.wnl.0000435551.90824.d0 PMID: 24122185
38. Fischer M, Kunkel A, Bublak P, Faiss JH, Hoffmann F, Sailer M, et al. How reliable is the classification of cognitive impairment across different criteria in early and late stages of multiple sclerosis? J Neurol Sci. 2014;343(1-2):91-9.