Immunoadsorption can improve cardiac function in transplant candidates with non-ischemic dilated cardiomyopathy associated with diabetes mellitus

Atherosclerosis Supplements

Volumn 18, Issue , 2015, Pages 124-133

  Dandel, Michael ^a   Englert, Angela ^a   Wallukat, Gerd ^a   Riese, Andrea ^a   Knosalla, Christoph ^a   Stein, Julia ^a   Hetzer, Roland ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Autoantibodies; Cardiomyopathy; Diabetes; Immunoadsorption; 1 receptors

Indexed keywords

ADSORBENT; AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CARDIOVASCULAR AGENT; CARVEDILOL; DIGOXIN; FUROSEMIDE; GLOBAFFIN; IMMUNOGLOBULIN; IMMUNOLOGIC AGENT; INSULIN; LISINOPRIL; LOSARTAN; METOPROLOL; RAMIPRIL; SPIRONOLACTONE; SYNTHETIC PEPTIDE; TORASEMIDE; UNCLASSIFIED DRUG; ADRB1 PROTEIN, HUMAN; BIOLOGICAL MARKER;

ADULT; ANTIBODY BLOOD LEVEL; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; COMPARATIVE EFFECTIVENESS; CONGESTIVE CARDIOMYOPATHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE ASSOCIATION; DISEASE DURATION; DIURETIC THERAPY; DRUG EFFICACY; DRUG SUBSTITUTION; EXERCISE TOLERANCE; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE OXYGEN CONSUMPTION; HEART TRANSPLANTATION; HEART VENTRICLE SIZE; HUMAN; IMMUNOADSORBENT; IMMUNOADSORPTION; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEW YORK HEART ASSOCIATION CLASS; PREVALENCE; PRIORITY JOURNAL; SURVIVAL RATE; TREATMENT RESPONSE; ADVERSE EFFECTS; APHERESIS; BLOOD; CARDIOMYOPATHY, DILATED; CASE CONTROL STUDY; COLOR DOPPLER ECHOCARDIOGRAPHY; CONVALESCENCE; DIABETIC CARDIOMYOPATHIES; DISEASE FREE SURVIVAL; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; HOSPITAL ADMISSION; IMMUNOLOGY; KAPLAN MEIER METHOD; MORTALITY; PATHOPHYSIOLOGY; PROCEDURES; RISK FACTOR; TIME FACTOR; TREATMENT OUTCOME;

ADULT; AUTOANTIBODIES; BIOMARKERS; BLOOD COMPONENT REMOVAL; CARDIOMYOPATHY, DILATED; CASE-CONTROL STUDIES; DIABETIC CARDIOMYOPATHIES; DISEASE-FREE SURVIVAL; ECHOCARDIOGRAPHY, DOPPLER, COLOR; EXERCISE TOLERANCE; FEMALE; HEART TRANSPLANTATION; HUMANS; IMMUNOSORBENT TECHNIQUES; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; RECEPTORS, ADRENERGIC, BETA-1; RECOVERY OF FUNCTION; RISK FACTORS; STROKE VOLUME; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT; WAITING LISTS;

EID: 84928880388     PISSN: 15675688     EISSN: 18785050     Source Type: Journal    
DOI: 10.1016/j.atherosclerosissup.2015.02.023     Document Type: Article

References (27)

1. Taylor D.O., Stehlik J., Edwards L.B., Aurora P., Christie J.D., Dobbels F., et al. Registry of the International Society for Heart and Lung Transplantation: twenty-sixth official adult heart transplant report-2009. J Heart Lung Transplant 2009, 28(10):1007-1022.
2. Bertoni A.G., Tsai A., Kasper E.K., Brancati F.L. Diabetes and idiopathic cardiomyopathy: a nationwide case-control study. Diabetes Care 2003, 26:2791-2795.
3. Murarka S., Movaed M.R. Diabetic cardiomyopathy. J Card Failure 2010, 16:971-979.
4. Ernande L., Derumeaux G. Diabetic cardiomyopathy, myth or reality?. Arch Cardiovasc Dis 2012, 105(4):218-225.
5. Gerli R., Rambotti P., Spinozzi F., Bertotto A., Chiodini V., Solinas P., et al. Immunologic studies of peripheral blood from patients with idiopathic dilated cardiomyopathy. Am Heart J 1986, 112:350-355.
6. Fu L.X., Magnusson Y., Bergh C.H., Liljeqvist J.A., Waagstein F., Hjalmarson A., et al. Location of functional autoimmune epitope on muscarinic acetylcholine receptor-2 in patients with idiopathic dilated cardiomyopathy. J Clin Invest 1993, 91(5):1964-1968.
7. Magnusson Y., Wallukat G., Waagstein F., Hjalmarson A., Hoebeke J. Autoimmunity in idiopathic dilated cardiomyopathy: characterization of antibodies against the beta-1-adrenoceptor with positive chronotropic effect. Circulation 1994, 89:2760-2767.
8. Wallukat G., Wollenberger A., Morwinski R., Pitschner H.F. Anti-β1-adrenoceptor antibodies with chronotropic activity from serum of patients with dilated cardio-myopathy: mapping of epitopes in the first and second extracellular loops. J Mol Cell Cardiol 1995, 27(1):397-406.
9. Müller J., Wallukat G., Weng Y., Dandel M., Spiegelsberger S., Semrau S., et al. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation 1997, 96:542-549.
10. Jahns R., Boivin V., Siegmund C., Inselmann G., Lohse M.J., Boege F. Autoantibodies activating human beta adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation 1999, 99:649-654.
11. Dandel M., Wallukat G., Potapov E., Hetzer R. Role of β1-adrenoceptor autoantibodies in the pathogenesis of dilated cardiomyopathy. Immunobiology 2012, 217(5):511-520.
12. Jahns R., Boivin V., Hein L., Triebel S., Angermann C.E., Ertl G., Lohse M.J. Direct evidence for beta-1 adrenergic receptor directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 2004, 113:1419-1429.
13. Dandel M., Wallukat G., Englert A., Lehmkuhl H.B., Knosalla C., Hetzer R. Long-term benefits of immunoadsorption in beta-1 adrenoreceptor autoantibody positive transplant candidates with dilated cardiomyopathy. Eur J Heart Fail 2012, 14(12):1374-1388.
14. Wallukat G., Reinke P., Dörffel W.V., Luther H.P., Bestvater K., Felix S.B., et al. Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption. Int J Cardiol 1996, 54:91-95.
15. Dörfel W.V., Felix S.B., Wallukat G., Brehme S., Bestvater K., Hofmann T., et al. Short term hemodynamic effects of immunoadsorption in dilated cardiomyopathy. Circulation 1997, 95:1994-1997.
16. Felix S.B., Staudt A., Dörffel W.V., Stangl V., Merkel K., Pohl M., et al. Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three month results from a randomized study. J Am Coll Cardiol 2000, 35(6):1590-1598.
17. Mobini R., Staudt A., Felix S.B., Baumann G., Wallukat G., Deinum J., et al. Hemodynamic improvement and removal of autoantibodies aganst beta-1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy. J Autoimmun 2003, 20:345-350.
18. Herda L.R., Trimpert C., Nauke U., Landsberger M., Hummel A., Beug D., et al. Effects of immunoadsorption and subsequent immunoglobulin G substitution on cardiopulmonary exercise capacity in patients with dilated cardiomyopathy. Am Heart J 2010, 159(5):809-816.
19. Staudt A., Hummel A., Ruppert J., Dörr M., Trimpert C., Birkenmeier K., et al. Immunoadsorption in dilated cardiomyopathy: 6 months results from a randomized study. Am Heart J 2006, 152. 712.el-712.e16.
20. Dandel M., Wallukat G., Englert A., Hetzer R. Immunoadsorption therapy for dilated cardiomyopathy and pulmonary arterial hypertension. Atherosclerosis Suppl 2013, 14:203-211.
21. Schwartz J., Winters J.L., Padmanabhan A., Balogun R.A., Delaney M., Linenberger M.L., et al. Guidelines on the use of therapeutic apheresis in clinical practice - evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue. J Clin Apheresis 2013, 28:145-284.
22. Hempel P., Karczewski P., Kohnert K.D., Raabe J., Lemke B., Kunze R., et al. Sera from patients with type 2 diabetes contain agonistic antibodies against G protein-couplet receptors. Scand J Immunol 2009, 70:159-160.
23. Zhao L.S., Liao Y.H., Xiang G.D., Wang M., Yue L., Zhou Z.H., et al. Positive rate of auto-antibodies against adrenergic receptors beta1 and angiotensin II type 1 receptors in the type 2 diabetes mellitus with or without hypertension. Zhonghua Xin Xue Guan Bing Za Zhi 2010, 38:139-142.
24. Ryden L., Grant P.J., Anker S.D., Berne C., Cosentino F., Danchin N., et al. Guidelines on diabetes, pre diabetes and cardiovascular diseases development in collaboration with the EASD: the Task Force on diabetes, pre diabetes and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the study of Diabetes (EASD). Eur Heart J 2013, 34:3035-3087.
25. McGuire D.K. Diabetes and the cardiovascular system. Braunwald's Heart Disease 2012, 1392-1409. Elsevier Saunders, Philadelphia. 9th ed. R.O. Bonow, D.L. Mann, D.P. Zipes, P. Libby (Eds.).
26. Stratton I.M., Adler A.I., Neil H.A., Matthews D.R., Manley S.E., Cull C.A., et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000, 321:405-412.
27. Litwin S.E. Diabetes and the heart: is there objective evidence of human diabetic cardiomyopathy?. Diabetes 2013, 62:3329-3330.