메뉴 건너뛰기




Volumn 12, Issue 5, 2015, Pages 296-301

Ki67 - No evidence for its use in node-positive breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR; KI 67 ANTIGEN; TAMOXIFEN; TUMOR MARKER;

EID: 84928825165     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2015.46     Document Type: Review
Times cited : (59)

References (40)
  • 1
    • 84856636292 scopus 로고    scopus 로고
    • Comparisons between different polychemotherapy regimens for early breast cancer: Meta-Analyses of long-Term outcome 100,000 women in 123 randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG).
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Comparisons between different polychemotherapy regimens for early breast cancer: meta-Analyses of long-Term outcome 100,000 women in 123 randomised trials. Lancet 370, 432-444 (2012).
    • (2012) Lancet , vol.370 , pp. 432-444
  • 2
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2012).
    • (2012) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 3
    • 0042838307 scopus 로고    scopus 로고
    • Breast cancer classification and prognosis based on gene expression profiles from a population-based study
    • Sotiriou, C. et al. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc. Natl Acad. Sci. USA 100, 10393-10398 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 10393-10398
    • Sotiriou, C.1
  • 4
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou, C. & Pusztai, L. Gene-expression signatures in breast cancer. N. Engl. J. Med. 360, 790-800 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 5
    • 84878344513 scopus 로고    scopus 로고
    • Ki67 and proliferation in breast cancer
    • Pathmanathan, N. & Balleine, R. L. Ki67 and proliferation in breast cancer. J. Clin. Pathol. 66, 512-516 (2013).
    • (2013) J. Clin. Pathol. , vol.66 , pp. 512-516
    • Pathmanathan, N.1    Balleine, R.L.2
  • 6
    • 66849140730 scopus 로고    scopus 로고
    • Ki-67 index, Her2 status, and prognosis of patients with luminal B breast cancer
    • Cheang, M. C. et al. Ki-67 index, Her2 status, and prognosis of patients with luminal B breast cancer. J. Natl Cancer Inst. 101, 736-750 (2009).
    • (2009) J. Natl Cancer Inst. , vol.101 , pp. 736-750
    • Cheang, M.C.1
  • 7
    • 34248595234 scopus 로고    scopus 로고
    • Ki-67 as prognostic marker in early breast cancer: A meta-Analysis of published studies involving 12,155 patients
    • de Azambuja, E. et al. Ki-67 as prognostic marker in early breast cancer: a meta-Analysis of published studies involving 12,155 patients. Br. J. Cancer 96, 1504-1513 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 1504-1513
    • De Azambuja, E.1
  • 8
    • 84928823962 scopus 로고    scopus 로고
    • Clinical significance of therapeutic Ki-67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer: Is it equally useful across tumour subtypes?
    • Sueta, A. et al. Clinical significance of therapeutic Ki-67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer: is it equally useful across tumour subtypes? Surgery 155, 923-935 (2014).
    • (2014) Surgery , vol.155 , pp. 923-935
    • Sueta, A.1
  • 9
    • 84888246639 scopus 로고    scopus 로고
    • Randomized trial of preoperative docetaxel with or without capecitabine after 4 cycles of 5-fluorouracil-epirubicin-cyclophosphamide (FEC) in early-stage breast cancer: Exploratory analyses identify Ki-67 as a predictive biomarker for response to neoadjuvant chemotherapy
    • Ohno, S. et al. Randomized trial of preoperative docetaxel with or without capecitabine after 4 cycles of 5-fluorouracil-epirubicin-cyclophosphamide (FEC) in early-stage breast cancer: exploratory analyses identify Ki-67 as a predictive biomarker for response to neoadjuvant chemotherapy. Breast Cancer Res. Treat. 142, 69-80 (2013).
    • (2013) Breast Cancer Res. Treat. , vol.142 , pp. 69-80
    • Ohno, S.1
  • 10
    • 84883325272 scopus 로고    scopus 로고
    • Personalizing the treatment of women with early breast cancer: Highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2013
    • Goldhirsch, A. et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2013. Ann. Oncol. 24, 2206-2223 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 2206-2223
    • Goldhirsch, A.1
  • 11
    • 84885366396 scopus 로고    scopus 로고
    • Primary breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Senkus, E. et al. Primary breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 24 (Suppl. 6), vi7-vi23 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. vi7-vi23
    • Senkus, E.1
  • 12
    • 73249140371 scopus 로고    scopus 로고
    • Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: A retrospective analysis of a randomised trial
    • Albain, K. S. et al. Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol. 11, 55-65 (2010).
    • (2010) Lancet Oncol. , vol.11 , pp. 55-65
    • Albain, K.S.1
  • 13
    • 77951637777 scopus 로고    scopus 로고
    • Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenauposal patients with breast cancer treated with anastrozole or tamoxifen: A TransATAC study
    • Dowsett, M. et al. Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenauposal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study. J. Clin. Oncol. 28, 1829-1834 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1829-1834
    • Dowsett, M.1
  • 14
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine. [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01272037?term=NCT01272037&rank=1 (2015).
    • (2015) ClinicalTrials.gov
  • 15
    • 59849127767 scopus 로고    scopus 로고
    • Recommendations from the EGAPP Working Group: Can tumour gene expression profiling improve outcomes in patients with breast cancer?
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group.
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group. Recommendations from the EGAPP Working Group: can tumour gene expression profiling improve outcomes in patients with breast cancer? Genet. Med. 11, 66-73 (2009).
    • (2009) Genet. Med. , vol.11 , pp. 66-73
  • 16
    • 84891459472 scopus 로고    scopus 로고
    • An international Ki-67 reproductibility study
    • Polley, M. Y. et al. An international Ki-67 reproductibility study. J. Natl Cancer Inst. 105, 1897-1906 (2013).
    • (2013) J. Natl Cancer Inst. , vol.105 , pp. 1897-1906
    • Polley, M.Y.1
  • 17
    • 84886793148 scopus 로고    scopus 로고
    • Interobserver concordance of Ki-67 labelling index in breast cancer: Japan Breast Cancer Research Group Ki-67 ring study
    • Mikami, Y. et al. Interobserver concordance of Ki-67 labelling index in breast cancer: Japan Breast Cancer Research Group Ki-67 ring study. Cancer Sci. 104, 1539-1543 (2013).
    • (2013) Cancer Sci. , vol.104 , pp. 1539-1543
    • Mikami, Y.1
  • 18
    • 84870388235 scopus 로고    scopus 로고
    • Comparison of the effect of different techniques for measurement of Ki-67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer
    • Gudlaugsson, E. et al. Comparison of the effect of different techniques for measurement of Ki-67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer. Histopathology 61, 1134-1144 (2012).
    • (2012) Histopathology , vol.61 , pp. 1134-1144
    • Gudlaugsson, E.1
  • 19
    • 84861478152 scopus 로고    scopus 로고
    • How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of Breast-And Gynecopathologists
    • Varga, Z. et al. How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of Breast-And Gynecopathologists. PLoS ONE 7, e37379 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e37379
    • Varga, Z.1
  • 20
    • 81555208345 scopus 로고    scopus 로고
    • Assessment of ki67 in breast cancer: Recommendations from the International Ki-67 in Breast Cancer Working Group
    • Dowsett, M. et al. Assessment of ki67 in breast cancer: recommendations from the International Ki-67 in Breast Cancer Working Group. J. Natl Cancer Inst. 103, 1656-1664 (2011).
    • (2011) J. Natl Cancer Inst. , vol.103 , pp. 1656-1664
    • Dowsett, M.1
  • 21
    • 84928825066 scopus 로고    scopus 로고
    • Interpathologists discrepancies in Ki-67 assessment in the PACS01 trial: An independent prognosis factor [abstract]
    • Suppl.
    • Penault-Llorca, F. et al. Interpathologists discrepancies in Ki-67 assessment in the PACS01 trial: an independent prognosis factor [abstract]. J. Clin. Oncol. 30 (Suppl.), a543 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. a543
    • Penault-Llorca, F.1
  • 22
    • 84899491271 scopus 로고    scopus 로고
    • A methodology to ensure and improve accuracy of Ki-67 labelling index estimation by automated digital image analysis in breast cancer tissue
    • Laurinavicius, A. et al. A methodology to ensure and improve accuracy of Ki-67 labelling index estimation by automated digital image analysis in breast cancer tissue. Breast Cancer Res. 16, R35 (2014).
    • (2014) Breast Cancer Res. , vol.16 , pp. R35
    • Laurinavicius, A.1
  • 23
    • 57149103724 scopus 로고    scopus 로고
    • Prognostic and predictive value of centrally reviewed Ki-67 labelling index in postmenauposal women with endocrine-responsive breast cancer: Results from Breast International Group trial 1-98 comparing adjuvant tamoxifen with letrozole
    • Viale, G. et al. Prognostic and predictive value of centrally reviewed Ki-67 labelling index in postmenauposal women with endocrine-responsive breast cancer: results from Breast International Group trial 1-98 comparing adjuvant tamoxifen with letrozole. J. Clin. Oncol. 26, 5569-5575 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5569-5575
    • Viale, G.1
  • 24
    • 81155133281 scopus 로고    scopus 로고
    • Prognostic value of a combined oestrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer
    • Cuzick, J. et al. Prognostic value of a combined oestrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer. J. Clin. Oncol. 29, 4273-4278 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4273-4278
    • Cuzick, J.1
  • 25
    • 33750576185 scopus 로고    scopus 로고
    • Re-evaluating adjuvant breast cancer trials: Assessing hormone receptor status by immunohistochemical versus extraction assays
    • Regan, M. M. et al. Re-evaluating adjuvant breast cancer trials: assessing hormone receptor status by immunohistochemical versus extraction assays. J. Natl Cancer Inst. 98, 1571-1581 (2006).
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 1571-1581
    • Regan, M.M.1
  • 26
    • 80052845090 scopus 로고    scopus 로고
    • A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors
    • Filipits, M. et al. A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors. Clin. Cancer Res. 17, 6012-6020 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6012-6020
    • Filipits, M.1
  • 27
    • 84928823784 scopus 로고    scopus 로고
    • Adjuvant! Online. http://www.adjuvantonline.com/index.jsp (2015).
    • (2015) Adjuvant Online.
  • 28
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and benefit of chemotherapy in women with node-negative, oestrogen receptor-positive breast cancer
    • Paik, S. et al. Gene expression and benefit of chemotherapy in women with node-negative, oestrogen receptor-positive breast cancer. J. Clin. Oncol. 24, 3726-3734 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3726-3734
    • Paik, S.1
  • 29
    • 77349118709 scopus 로고    scopus 로고
    • Predictive markers of anthracycline benefit: A prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601)
    • Bartlett, J. M. et al. Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601). Lancet Oncol. 11, 266-274 (2010).
    • (2010) Lancet Oncol. , vol.11 , pp. 266-274
    • Bartlett, J.M.1
  • 30
    • 67649983962 scopus 로고    scopus 로고
    • Ki-67 expression and docetaxel efficacy in patients with oestrogen receptor-positive breast cancer
    • Penault-Llorca, F. et al. Ki-67 expression and docetaxel efficacy in patients with oestrogen receptor-positive breast cancer. J. Clin. Oncol. 27, 2809-2815 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2809-2815
    • Penault-Llorca, F.1
  • 31
    • 62549091454 scopus 로고    scopus 로고
    • Breast cancer subtypes and response to docetaxel in node-positive breast cancer: Use of an immunohistochemical definition in the BCIRG 001 trial
    • Hugh, J. et al. Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J. Clin. Oncol. 27, 1168-1176 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1168-1176
    • Hugh, J.1
  • 32
    • 84905187179 scopus 로고    scopus 로고
    • Final analysis of the prospective WSG-AGO EC-Doc versus FEC phase III trial in intermediate-risk (pN1) early breast cancer: Efficacy and predictive value of Ki-67 expression
    • Nitz, U. et al. Final analysis of the prospective WSG-AGO EC-Doc versus FEC phase III trial in intermediate-risk (pN1) early breast cancer: efficacy and predictive value of Ki-67 expression. Ann. Oncol. 25, 1551-1557 (2014).
    • (2014) Ann. Oncol. , vol.25 , pp. 1551-1557
    • Nitz, U.1
  • 33
    • 84904188903 scopus 로고    scopus 로고
    • Pathological complete response and long-Term clinical benefit in breast cancer: The CTNeoBC pooled analysis
    • Cortazar, P. et al., Pathological complete response and long-Term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 384, 164-172 (2014).
    • (2014) Lancet , vol.384 , pp. 164-172
    • Cortazar, P.1
  • 34
    • 84882977388 scopus 로고    scopus 로고
    • Response-guided neoadjuvant chemotherapy for breast cancer
    • von Minckwitz, G. et al. Response-guided neoadjuvant chemotherapy for breast cancer. J. Clin. Oncol. 31, 3623-3630 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3623-3630
    • Von Minckwitz, G.1
  • 35
    • 84896872171 scopus 로고    scopus 로고
    • Prognostic value of tumour-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: A retrospective multicentre study
    • Dieci, M. V. et al. Prognostic value of tumour-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: a retrospective multicentre study. Ann. Oncol. 25, 611-618 (2014).
    • (2014) Ann. Oncol. , vol.25 , pp. 611-618
    • Dieci, M.V.1
  • 36
    • 53249154813 scopus 로고    scopus 로고
    • Outcome prediction for oestrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumour characteristics
    • Ellis, M. J. et al. Outcome prediction for oestrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumour characteristics. J. Natl Cancer Inst. 100, 1380-1388 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , pp. 1380-1388
    • Ellis, M.J.1
  • 37
    • 84875804295 scopus 로고    scopus 로고
    • Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
    • Ferlay, J. et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur. J. Cancer 49, 1374-1403 (2013).
    • (2013) Eur. J. Cancer , vol.49 , pp. 1374-1403
    • Ferlay, J.1
  • 38
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02338310?term=NCT02338310&rank=1 (2015).
    • (2015) ClinicalTrials.gov
  • 39
    • 84867911904 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00310180?term=NCT00310180&rank=1 (2015).
    • (2015) ClinicalTrials.gov [Online]
  • 40
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00433589?term=NCT00433589&rank=1 (2013).
    • (2013) ClinicalTrials.gov


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.