Randomized double blind placebo-controlled study to demonstrate that antibiotics are not needed in moderate acute exacerbations of COPD - The ABACOPD Study

BMC Pulmonary Medicine

Volumn 15, Issue 1, 2015, Pages

  Rohde, Gernot G U ^a,c,d   Koch, Armin ^b   Welte, Tobias ^b,c,d   Dreher, M ^e   Cornelissen, C ^e   Knuppel W ^f   Dressel, S ^f   Bauer, T ^g   Sabha, T ^g   Pankow, W ^h   Lies, A ^h   de Roux, A ⁱ   Dallwitz, N ⁱ   Pociuli, O ^j   Zierock, P ^j   Hauptmeier, B ^k   Wehde, D ^k   Herzmann, C ^l   Lange, C ^l   Schaaf, B ^m   Teipel, C ^m   Hoffken G ⁿ   Kolditz, M ⁿ   Idzko, M ^o   Seuthe, B ^o   Glaser S ^p   Ewert, R ^p   Nilius, G ^q   Franke, K J ^q   Weiss, C ^r   Zelniker, T ^r   Kohnlein T ^b   Freise, J ^b   Andreas, S ^s   Hammerl, P ^s   Pletz, M ^s,t   Hagel, S ^t   Dalhoff, K ^u   Dromann D ^u   Buschmann, H ^v   Kroning R ^v   Schaberg, T ^w   Gobel C ^w   Randerath, W ^x   Priegnitz, C ^x   Stieglitz, S ^x   Hagmeyer, S ^x   Rasche, K ^y   Leidag, M ^y   Barten, G ^c   Kroner W ^c   Naim, J ^c   Abrahamczik, M ^c   Koch, A ^b   Gonnermann, A ^b   Stichtenoth, D ^b   Von Der Leyen, H ^z   Breuer, D ^z   Craul, M ^z   Welte, T ^b   Suttorp, N ^aa   Stenger, S ^ab   Rohde, G ^a   Schutte H ^ac   Rupp, J ^u   Illmann, T ^ad   Wallner, M ^ad   Illig, T ^b   Klopp, N ^b   Bauer, S ^b   more..

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c CAPNETZ STIFTUNG   (Germany)

^d German Center for Lung Research   (Germany)

^e UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^f Hospital   (Germany)

^g Helios Klinkum Emil von Behring   (Germany)

^h Clinic for Internal Medicine Pneumology and Infectiology Vivantes Clinical Center   (Germany)

ⁱ Pneumologe   (Germany)

^j Vivantes Clinical Center   (Germany)

^k RUHR UNIVERSITY BOCHUM   (Germany)

^l RESEARCH CENTER BORSTEL   (Germany)

^m Clinical Center   (Germany)

ⁿ UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^o UNIVERSITY OF FREIBURG   (Germany)

^p UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^q Helios Clinic   (Germany)

^r UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^s Lung Clinic   (Germany)

^t JENA UNIVERSITY HOSPITAL   (Germany)

^u UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^v Bruderkrankenhaus St Josef Paderborn   (Germany)

^w Center of Pneumology   (Germany)

^x Krankenhaus Bethanien Solingen   (Germany)

^y HELIOS KLINIKUM WUPPERTAL   (Germany)

^z Hannover Clinical Trial Center GmbH   (Germany)

^aa CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^ab UNIVERSITY OF ULM   (Germany)

^ac Ernst von Bergmann Clinic   (Germany)

^ad 2mt Software GmbH   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPENICILLIN; PREDNISOLONE; SULTAMICILLIN; AMPICILLIN; BRONCHODILATING AGENT; SULBACTAM;

ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MODERATE ACUTE EXACERBATION CHRONIC OBSTRUCTIVE LUNG DISEASE; OXYGEN THERAPY; RANDOMIZED CONTROLLED TRIAL; RELAPSE; STANDARDIZATION; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; ACUTE DISEASE; AGED; ANOXIA; CLINICAL TRIAL; COMBINATION DRUG THERAPY; DISEASE COURSE; DRUG ADMINISTRATION; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TREATMENT OUTCOME; VERY ELDERLY;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; AMPICILLIN; ANOXIA; BRONCHODILATOR AGENTS; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, BACTERIAL; DRUG THERAPY, COMBINATION; HUMANS; MALE; MIDDLE AGED; OXYGEN INHALATION THERAPY; PREDNISOLONE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESEARCH DESIGN; SULBACTAM; TREATMENT OUTCOME;

EID: 84928813719     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-15-5     Document Type: Article

References (23)

1. Chen DK, McGeer A, de Azavedo JC, Low DE. Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network. N Engl J Med. 1999;341(4):233-9.
2. Ford ES, Croft JB, Mannino DM, Wheaton AG, Zhang X, Giles WH. COPD surveillance-United States, 1999-2011. Chest. 2013;144(1):284-305.
3. Lindenauer PK, Pekow P, Gao S, Crawford AS, Gutierrez B, Benjamin EM. Quality of care for patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 2006;144(12):894-903.
4. Celli BR, Barnes PJ. Exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 2007;29(6):1224-38.
5. Sethi S, Evans N, Grant BJB, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 2002;347(7):465-71.
6. Rohde G, Wiethege A, Borg I, Kauth M, Bauer TT, Gillissen A, et al. Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalization-a case-control study. Thorax. 2003;58(1):37-42.
7. Seemungal T, Harper-Owen R, Bhowmik A, Moric I, Sanderson G, Message S, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164:1618-23.
8. Rohde GG. Prudent use of antibiotics: acute exacerbation of COPD as an example. Eur Respir J. 2010;36(5):983-5.
9. Chalmers JD, Al-Khairalla M, Short PM, Fardon TC, Winter JH. Proposed changes to management of lower respiratory tract infections in response to the Clostridium difficile epidemic. J Antimicrob Chemother. 2010;65(4):608-18.
10. Vollenweider DJ, Jarrett H, Steurer-Stey CA, Garcia-Aymerich J, Puhan MA. Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;12:CD010257.
11. Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2011;64(4):380-2.
12. Llor C, Moragas A, Hernandez S, Bayona C, Miravitlles M. Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186(8):716-23.
13. Nouira S, Marghli S, Belghith M, Besbes L, Elatrous S, Abroug F. Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: a randomised placebo-controlled trial. Lancet. 2001;358(9298):2020-5.
14. Molstad S, Erntell M, Hanberger H, Melander E, Norman C, Skoog G, et al. Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme. Lancet Infect Dis. 2008;8(2):125-32.
15. Daniels JM, Snijders D, de Graaff CS, Vlaspolder F, Jansen HM, Boersma WG. Antibiotics in addition to systemic corticosteroids for acute exacerbations of COPD. Am J Respir Crit Care Med. 2010;181:150-7.
16. Ram FS, Rodriguez-Roisin R, Granados-Navarrete A, Garcia-Aymerich J, Barnes NC. Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2006;2:CD004403.
17. Bantar C, Sartori B, Vesco E, Heft C, Saul M, Salamone F, et al. A hospitalwide intervention program to optimize the quality of antibiotic use: impact on prescribing practice, antibiotic consumption, cost savings, and bacterial resistance. Clin Infect Dis. 2003;37(2):180-6.
18. Hoffken G, Lorenz J, Kern W, Welte T, Bauer T, Dalhoff K, et al. Epidemiology, diagnosis, antimicrobial therapy and management of community-acquired pneumonia and lower respiratory tract infections in adults. Guidelines of the Paul-Ehrlich-Society for Chemotherapy, the German Respiratory Society, the German Society for Infectiology and the Competence Network CAPNETZ Germany. Pneumologie. 2009;63(10):e1-68.
19. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009;302(10):1059-66.
20. Jorgensen AF, Coolidge J, Pedersen PA, Petersen KP, Waldorff S, Widding E. Amoxicillin in treatment of acute uncomplicated exacerbations of chronic bronchitis. A double-blind, placebo-controlled multicentre study in general practice. Scand J PrimHealth Care. 1992;10(1):7-11.
21. Anthonisen NR, Manfreda J, Warren CPW, Hershfield ES, Harding GKM, Nelson NA. Antibiotic therapy in acute exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987;106(2):196-204.
22. Leuppi JD, Schuetz P, Bingisser R, Bodmer M, Briel M, Drescher T, et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA. 2013;309(21):2223-31.
23. Wilson R, Sethi S, Anzueto A, Miravitlles M. Antibiotics for treatment and prevention of exacerbations of chronic obstructive pulmonary disease. J Infect. 2013;67(6):497-515.