Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms

Neural Regeneration Research

Volumn 10, Issue 4, 2015, Pages 651-658

  Guo, Zhi Yuan ^a   Sun, Xun ^a   Xu, Xiao Long ^a   Zhao, Qing ^a   Peng, Jiang ^a,b   Wang, Yu ^a,b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b Neural Regeneration Co innovation Center of Jiangsu Province   (China)

Author keywords

Axons; Conditioned medium; Dorsal root ganglion; Human umbilical cord derived mesenchymal stem cells; Nerve regeneration; Neural regeneration; Neurotrophic factors; Peripheral nerve regeneration; Schwann cells

Indexed keywords

5' NUCLEOTIDASE; BETA1 INTEGRIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CD71 ANTIGEN; COLLAGEN TYPE 1; CYTOKINE ANTIBODY; ENDOGLIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HERMES ANTIGEN; HOE 33342; INTERLEUKIN 6; LAMININ; LEUKEMIA INHIBITORY FACTOR; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR BETA SUBUNIT; NEUROTROPHIN 3; NEUROTROPHIN 4; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; SOMATOMEDIN C; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; DENSITOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NERVE FIBER REGENERATION; NERVE FUNCTION; NONHUMAN; PARACRINE SIGNALING; PERIPHERAL NERVE; PERIPHERAL NERVE INJURY; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; PROTEIN MICROARRAY; RAT; SCHWANN CELL CULTURE; SPINAL GANGLION; UMBILICAL CORD; WESTERN BLOTTING;

EID: 84928777744     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.155442     Document Type: Article

References (37)

1. Alsanie WF, Niclis JC, Petratos S (2013) Human embryonic stem cellderived oligodendrocytes: protocols and perspective. Stem Cells Dev 22:2459-2476.
2. Bongso A, Fong CY (2013) The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton’s jelly of the human umbilical cord. Stem Cell Rev 9:226-240.
3. Caplan AI (2009) Why are MSCs therapeutic? New data: new insight. J Pathol 217:318-324.
4. Caplan AI, Dennis JE (2006) Mesenchymal stem cells as trophic mediators. J Cell Biochem 98:1076-1084.
5. Chen X, Wang XD, Chen G, Lin WW, Yao J, Gu XS (2006) Study of in vivo differentiation of rat bone marrow stromal cells into schwann cell-like cells. Microsurgery 26:111-115.
6. Cui B, Li E, Yang B, Wang B (2014) Human umbilical cord blood-derived mesenchymal stem cell transplantation for the treatment of spinal cord injury. Exp Ther Med 7:1233-1236.
7. Dai G, Liu X, Zhang Z, Yang Z, Dai Y, Xu R (2013) Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury. Brain Res 1533:73-79.
8. Dubový P, Raška O, Klusáková I, Stejskal L, Celakovský P, Haninec P (2011) Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-toside neurorrhaphy. BMC Neurosci 12:58.
9. Fong CY, Tam K, Cheyyatraivendran S, Gan SU, Gauthaman K, Armugam A, Jeyaseelan K, Choolani M, Biswas A, Bongso A (2014) Human Wharton’s jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds. J Cell Biochem 115:290-302.
10. Gao X, Wang Y, Chen J, Peng J (2013) The role of peripheral nerve ECM components in the tissue engineering nerve construction. Rev Neurosci 24:443-453.
11. Gu Y, Ji Y, Zhao Y, Liu Y, Ding F, Gu X, Yang Y (2012) The influence of substrate stiffness on the behavior and functions of Schwann cells in culture. Biomaterials 33:6672-6681.
12. Hsu YC, Chen SL, Wang DY, Chiu IM (2013) Stem cell-based therapy in neural repair. Biomed J 36:98-105.
13. Huang JF, Huang JF, Zhang WC (2014) Bone marrow mesenchymal stem cells differentiate into neuron-like cells induced by combination of two cytokines. Zhongguo Zuzhi Gongcheng Yanjiu 18:829-834.
14. Jiang PC, Xiong WP, Wang G, Ma C, Yao WQ, Kendell SF, Mehling BM, Yuan XH, Wu DC (2013) A clinical trial report of autologous bone marrow-derived mesenchymal stem cell transplantation in patients with spinal cord injury. Exp Ther Med 6:140-146.
15. Kingham PJ, Kalbermatten DF, Mahay D, Armstrong SJ, Wiberg M, Terenghi G (2007) Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro. Exp Neurol 207:267-274.
16. Kumar AA, Kumar SR, Narayanan R, Arul K, Baskaran M (2009) Autologous bone marrow derived mononuclear cell therapy for spinal cord injury: A phase I/II clinical safety and primary efficacy data. Exp Clin Transplant 7:241-248.
17. Lai Y, Sun Y, Skinner CM, Son EL, Lu Z, Tuan RS, Jilka RL, Ling J, Chen XD (2010) Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells. Stem Cells Dev 19:1095-1107.
18. Li WW, Yao XY, Yang LM, Zhao PW, Zhang GH (2014) Induced differentiation of human umbilical cord mesenchymal stem cells into neural stem cells in vitro. Zhongguo Zuzhi Gongcheng Yanjiu 18:75-80.
19. Li Z, Peng J, Wang G, Yang Q, Yu H, Guo Q, Wang A, Zhao B, Lu S (2008) Effects of local release of hepatocyte growth factor on peripheral nerve regeneration in acellular nerve grafts. Exp Neurol 214:47-54.
20. Liu S, Yuan M, Hou K, Zhang L, Zheng X, Zhao B, Sui X, Xu W, Lu S, Guo Q (2012) Immune characterization of mesenchymal stem cells in human umbilical cord Wharton’s jelly and derived cartilage cells. Cell Immunol 278:35-44.
21. Ma HY (2014) Bone marrow mesenchymal stem cell transplantation combined with edaravone inhibits neuronal apoptosis after cerebral infarction. Zhongguo Zuzhi Gongcheng Yanjiu 18:1615-1620.
22. Matsuse D, Kitada M, Kohama M, Nishikawa K, Makinoshima H, Wakao S, Fujiyoshi Y, Heike T, Nakahata T, Akutsu H, Umezawa A, Harigae H, Kira J, Dezawa M (2010) Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration. J Neuropathol Exp Neurol 69:973-985.
23. Peng J, Wang Y, Zhang L, Zhao B, Zhao Z, Chen J, Guo Q, Liu S, Sui X, Xu W, Lu S (2011) Human umbilical cord Wharton’s jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro. Brain Res Bull 84:235-243.
24. Ribeiro J, Gartner A, Pereira T, Gomes R, Lopes MA, Gonçalves C, Varejão A, Luís AL, Maurício AC (2013) Perspectives of employing mesenchymal stem cells from the Wharton’s jelly of the umbilical cord for peripheral nerve repair. Int Rev Neurobiol 108:79-120.
25. Romanov YA, Svintsitskaya VA, Smirnov VN (2003) Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 21:105-110.
26. Shakhbazau A, Mohanty C, Shcharbin D, Bryszewska M, Caminade AM, Majoral JP, Alant J, Midha R (2013) Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve. J Control Release 172:841-851.
27. Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C (2008) Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J Invest Dermatol 128:2031-2040.
28. Verheyen A, Peeraer E, Lambrechts D, Poesen K, Carmeliet P, Shibuya M, Pintelon I, Timmermans JP, Nuydens R, Meert T (2013) Therapeutic potential of VEGF and VEGF-derived peptide in peripheral neuropathies. Neuroscience 244:77-89.
29. Wang J, Ding F, Gu Y, Liu J, Gu X (2009) Bone marrow mesenchymal stem cells promote cell proliferation and neurotrophic function of Schwann cells in vitro and in vivo. Brain Res 1262:7-15.
30. Wang ZL, Cheng SM, Ma MM, Ma YP, Yang JP, Xu GL, Liu XF (2008) Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia. Neurosci Lett 446:30-35.
31. Yang CC, Shih YH, Ko MH, Hsu SY, Cheng H, Fu YS (2008) Transplantation of human umbilical mesenchymal stem cells from Wharton’s jelly after complete transection of the rat spinal cord. PLoS One 3:e3336.
32. Yang J, Wu H, Hu N, Gu X, Ding F (2009) Effects of bone marrow stromal cell-conditioned medium on primary cultures of peripheral nerve tissues and cells. Neurochem Res 34:1685-1694.
33. Yang Q, Peng J, Guo Q, Huang J, Zhang L, Yao J, Yang F, Wang S, Xu W, Wang A, Lu S (2008) A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells. Biomaterials 29:2378-2387.
34. Yang Y, Chen X, Ding F, Zhang P, Liu J, Gu X (2007) Biocompatibility evaluation of silk fibroin with peripheral nerve tissues and cells in vitro. Biomaterials 28:1643-1652.
35. Zhang XP, Xiao Q, Lv G (2014) Chitosan conduits with human umbilical cord mesenchymal stem cells induce differentiation and growth of the nerve lateral bud. Zhongguo Zuzhi Gongcheng Yanjiu 18:6985-6989.
36. Zhao T, Yan W, Xu K, Qi Y, Dai X, Shi Z (2013) Combined treatment with platelet-rich plasma and brain-derived neurotrophic factor-overexpressing bone marrow stromal cells supports axonal remyelination in a rat spinal cord hemi-section model. Cytotherapy 15:792-804.
37. Zhu JX, Tao HR, Shen ZL (2014) Rat’s Schwann cells induce neural differentiation of human umbilical cord mesenchymal stem cells. Zhongguo Zuzhi Gongcheng Yanjiu 18:7250-7254.