High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus

American Journal of Nephrology

Volumn 41, Issue 3, 2015, Pages 241-247

  Orjuela, Alvaro ^a,c   Suwanichkul, Adisak ^a,c   Canter, Debra ^a   Minard, Charles G ^b   Devaraj, Sridevi ^a,c   Hicks, M John ^a,c   Muscal, Eyal ^a   Wenderfer, Scott E ^a,c  

^a Department of Pediatrics ^*  (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Glomerulonephritis; Inflammation; Pediatrics

Indexed keywords

DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; ANTI-IGG; ANTIIDIOTYPIC ANTIBODY; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; BIOLOGICAL MARKER; DNA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MEDICAL RECORD REVIEW; MOUSE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SYSTEMIC LUPUS ERYTHEMATOSUS; ADOLESCENT; ANIMAL; BASEMENT MEMBRANE; BLOOD; C57BL MOUSE; CASE CONTROL STUDY; COMPLICATION; DISEASE MODEL; IMMUNOLOGY; LUPUS NEPHRITIS; MALE; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE;

ADOLESCENT; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; BASEMENT MEMBRANE; BIOMARKERS; CASE-CONTROL STUDIES; CHILD; DISEASE MODELS, ANIMAL; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED MRL LPR;

EID: 84928746915     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000381965     Document Type: Article

References (16)

1. Woodroffe AJ, Border WA, Theofilopoulos AN, Götze O, Glassock RJ, Dixon FJ, Wilson CB: Detection of circulating immune complexes in patients with glomerulonephritis. Kidney Int 1977; 12: 268-278.
2. Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM: Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 1978; 62: 1275-1287.
3. Yung S, Chan TM: Anti-DNA antibodies in the pathogenesis of lupus nephritis-the emerging mechanisms. Autoimmun Rev 2008; 7: 317-321.
4. Krishnan MR, Wang C, Marion TN: Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice. Kidney Int 2012; 82: 184-192.
5. Barsalou J, Levy DM, Silverman ED: An update on childhood-onset systemic lupus erythematosus. Curr Opin Rheumatol 2013; 25: 616-622.
6. Sturfelt G, Truedsson L: Complement and its breakdown products in SLE. Rheumatology (Oxford) 2005; 44: 1227-1232.
7. Mok CC: Biomarkers for lupus nephritis: a critical appraisal. J Biomed Biotechnol 2010; 2010: 638413.
8. Brunner HI, Bennett MR, Mina R, Suzuki M, Petri M, Kiani AN, Pendl J, Witte D, Ying J, Rovin BH, Devarajan P: Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Arthritis Rheum 2012; 64: 2687-2697.
9. Watson L, Beresford M: Urine biomarkers in juvenile-onset SLE nephritis. Pediatr Nephrol 2013; 28: 363-374.
10. Kavanaugh AF, Solomon DH: Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-DNA antibody tests. Arthritis Rheum 2002; 47: 546-555.
11. Marion TN, Lawton AR 3rd, Kearney JF, Briles DE: Anti-DNA autoantibodies in (NZB X NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotype. J Immunol 1982; 128: 668-674.
12. Li QZ, Xie C, Wu T, Mackay M, Aranow C, Putterman C, Mohan C: Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest 2005; 115: 3428-3439.
13. Muscal E, Bloom DR, Hunter JV, Myones BL: Neurocognitive deficits and neuroimaging abnormalities are prevalent in children with lupus: clinical and research experiences at a US pediatric institution. Lupus 2010; 19: 268-279.
14. Hochberg MC: Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725.
15. Schwartz GJ, Munõz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL: New equations to estimate GFR in children with CKD. J Am Soc Nephrol 2009; 20: 629-637.
16. Wenderfer SE, Ke B, Hollmann TJ, Wetsel RA, Lan HY, Braun MC: C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice. J Am Soc Nephrol 2005; 16: 3572-3582.