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Volumn 14, Issue , 2014, Pages S71-S77

Novel drug combinations for the management of relapsed/refractory multiple myeloma

Author keywords

Histone deacetylase inhibitors; Immunomodulatory agents; Monoclonal antibodies; Proteasome inhibitors; Treatment

Indexed keywords

BORTEZOMIB; CARFILZOMIB; DARATUMUMAB; DEXAMETHASONE; DOXORUBICIN; ELOTUZUMAB; HOST FACTOR; ISATUXIMAB; LENALIDOMIDE; PANOBINOSTAT; POMALIDOMIDE; PROTEASOME INHIBITOR; RICOLINOSTAT; THALIDOMIDE; VORINOSTAT; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE INHIBITOR; MONOCLONAL ANTIBODY; OLIGOPEPTIDE;

EID: 84928640823     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2014.06.016     Document Type: Conference Paper
Times cited : (13)

References (37)
  • 1
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • S.K. Kumar, S.V. Rajkumar, A. Dispenzieri, and et al. Improved survival in multiple myeloma and the impact of novel therapies Blood 111 2008 2516 2520
    • (2008) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 2
    • 84856719479 scopus 로고    scopus 로고
    • Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study
    • S.K. Kumar, J.H. Lee, J.J. Lahuerta, and et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study Leukemia 26 2012 149 157
    • (2012) Leukemia , vol.26 , pp. 149-157
    • Kumar, S.K.1    Lee, J.H.2    Lahuerta, J.J.3
  • 3
    • 84893782640 scopus 로고    scopus 로고
    • IMWG consensus on risk stratification in multiple myeloma [published online August 26, 2013]
    • Chng WJ, Dispenzieri A, Chim CS, et al. IMWG consensus on risk stratification in multiple myeloma [published online August 26, 2013]. Leukemia. http://dx.doi.org/10.1038/leu.2013.247.
    • Leukemia
    • Chng, W.J.1    Dispenzieri, A.2    Chim, C.S.3
  • 4
    • 84867295563 scopus 로고    scopus 로고
    • A phase 2 study of single agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
    • D.S. Siegel, T. Martin, M. Wang, and et al. A phase 2 study of single agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma Blood 120 2012 2817 2825
    • (2012) Blood , vol.120 , pp. 2817-2825
    • Siegel, D.S.1    Martin, T.2    Wang, M.3
  • 5
    • 84890429728 scopus 로고    scopus 로고
    • Treatment outcomes in patients with relapsed and refractory multiple myeloma and high-risk cytogenetics receiving single-agent carfilzomib in the PX-171-003-A1 study
    • A.J. Jakubowiak, D.S. Siegel, T. Martin, and et al. Treatment outcomes in patients with relapsed and refractory multiple myeloma and high-risk cytogenetics receiving single-agent carfilzomib in the PX-171-003-A1 study Leukemia 27 2013 2351 2356
    • (2013) Leukemia , vol.27 , pp. 2351-2356
    • Jakubowiak, A.J.1    Siegel, D.S.2    Martin, T.3
  • 6
    • 84887609779 scopus 로고    scopus 로고
    • Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • M. Wang, T. Martin, W. Bensinger, and et al. Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma Blood 122 2013 3122 3128
    • (2013) Blood , vol.122 , pp. 3122-3128
    • Wang, M.1    Martin, T.2    Bensinger, W.3
  • 7
    • 84902134904 scopus 로고    scopus 로고
    • Phase I/II dose expansion of a multi-center trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/refractory multiple myeloma
    • J.J. Shah, E.A. Stadtmauer, R. Abonour, and et al. Phase I/II dose expansion of a multi-center trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/refractory multiple myeloma Blood 122 2013 690
    • (2013) Blood , vol.122 , pp. 690
    • Shah, J.J.1    Stadtmauer, E.A.2    Abonour, R.3
  • 8
    • 84887723566 scopus 로고    scopus 로고
    • Pomalidomide
    • M.Q. Lacy, and A.R. McCurdy Pomalidomide Blood 122 2013 2305 2309
    • (2013) Blood , vol.122 , pp. 2305-2309
    • Lacy, M.Q.1    McCurdy, A.R.2
  • 9
    • 4344693453 scopus 로고    scopus 로고
    • Phase i study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma
    • S.A. Schey, P. Fields, J.B. Bartlett, and et al. Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma J Clin Oncol 22 2004 3269 3276
    • (2004) J Clin Oncol , vol.22 , pp. 3269-3276
    • Schey, S.A.1    Fields, P.2    Bartlett, J.B.3
  • 10
    • 40449135275 scopus 로고    scopus 로고
    • Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation
    • M.J. Streetly, K. Gyertson, Y. Daniel, and et al. Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation Br J Haematol 141 2008 41 51
    • (2008) Br J Haematol , vol.141 , pp. 41-51
    • Streetly, M.J.1    Gyertson, K.2    Daniel, Y.3
  • 11
    • 78149468560 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
    • M.Q. Lacy, S.R. Hayman, M.A. Gertz, and et al. Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM) Leukemia 24 2010 1934 1939
    • (2010) Leukemia , vol.24 , pp. 1934-1939
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 12
    • 84877605245 scopus 로고    scopus 로고
    • Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib
    • P.G. Richardson, D. Siegel, R. Baz, and et al. Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib Blood 121 2013 1961 1967
    • (2013) Blood , vol.121 , pp. 1961-1967
    • Richardson, P.G.1    Siegel, D.2    Baz, R.3
  • 13
    • 84884702483 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): A randomized, open-label, phase 3 trial
    • J.S. Miguel, K. Weisel, P. Moreau, and et al. Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomized, open-label, phase 3 trial Lancet Oncol 14 2013 1055 1066
    • (2013) Lancet Oncol , vol.14 , pp. 1055-1066
    • Miguel, J.S.1    Weisel, K.2    Moreau, P.3
  • 14
    • 84908365114 scopus 로고    scopus 로고
    • MM-005: A phase 1 trial of pomalidomide, bortezomib, and low-dose dexamethasone (PVD) in relapsed and/or refractory multiple myeloma (RRMM)
    • P.G. Richardson, C.C. Hofmeister, D. Siegel, and et al. MM-005: a phase 1 trial of pomalidomide, bortezomib, and low-dose dexamethasone (PVD) in relapsed and/or refractory multiple myeloma (RRMM) Blood 122 2013 1969
    • (2013) Blood , vol.122 , pp. 1969
    • Richardson, P.G.1    Hofmeister, C.C.2    Siegel, D.3
  • 15
    • 84911477702 scopus 로고    scopus 로고
    • A phase I/II trial of pomalidomide, bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma
    • J. Mikhael, V. Roy, P.G. Richardson, and et al. A phase I/II trial of pomalidomide, bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma Blood 122 2013 1940
    • (2013) Blood , vol.122 , pp. 1940
    • Mikhael, J.1    Roy, V.2    Richardson, P.G.3
  • 16
    • 84952026199 scopus 로고    scopus 로고
    • Oral weekly cyclophosphamide in combination with pomalidomide and dexamethasone for relapsed and refractory myeloma: Report of the dose escalation cohort
    • R. Baz, T. Martin, M. Alsina, and et al. Oral weekly cyclophosphamide in combination with pomalidomide and dexamethasone for relapsed and refractory myeloma: report of the dose escalation cohort Blood 122 2013 3200
    • (2013) Blood , vol.122 , pp. 3200
    • Baz, R.1    Martin, T.2    Alsina, M.3
  • 17
    • 84908363392 scopus 로고    scopus 로고
    • ClaPD (clarithromycin, pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma
    • T. Mark, A. Boyer, A.C. Rossi, and et al. ClaPD (clarithromycin, pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma Blood 122 2013 1940
    • (2013) Blood , vol.122 , pp. 1940
    • Mark, T.1    Boyer, A.2    Rossi, A.C.3
  • 18
    • 52049104695 scopus 로고    scopus 로고
    • CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma
    • E.D. Hsi, R. Steinle, B. Balasa, and et al. CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma Clin Cancer Res 14 2008 2775 2784
    • (2008) Clin Cancer Res , vol.14 , pp. 2775-2784
    • Hsi, E.D.1    Steinle, R.2    Balasa, B.3
  • 19
    • 51649083849 scopus 로고    scopus 로고
    • Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Y.T. Tai, M. Dillon, W. Song, and et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu Blood 112 2008 1329 1337
    • (2008) Blood , vol.112 , pp. 1329-1337
    • Tai, Y.T.1    Dillon, M.2    Song, W.3
  • 20
    • 84864118302 scopus 로고    scopus 로고
    • A phase I, muliti-center, open-label, dose-escalation study of elotuzumab in patients with advanced multiple myeloma
    • J.A. Zonder, A.F. Mohrbacher, S. Singhal, and et al. A phase I, muliti-center, open-label, dose-escalation study of elotuzumab in patients with advanced multiple myeloma Blood 120 2012 552 559
    • (2012) Blood , vol.120 , pp. 552-559
    • Zonder, J.A.1    Mohrbacher, A.F.2    Singhal, S.3
  • 21
    • 84862672400 scopus 로고    scopus 로고
    • Phase i trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in patients with relapsed/refractory multiple myeloma
    • A.J. Jakubowiak, D.M. Benson, W. Bensinger, and et al. Phase I trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in patients with relapsed/refractory multiple myeloma J Clin Oncol 30 2012 1960 1965
    • (2012) J Clin Oncol , vol.30 , pp. 1960-1965
    • Jakubowiak, A.J.1    Benson, D.M.2    Bensinger, W.3
  • 22
    • 84863919927 scopus 로고    scopus 로고
    • Elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma
    • S. Lonial, R. Vij, J.L. Harousseau, and et al. Elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma J Clin Oncol 30 2012 1953 1959
    • (2012) J Clin Oncol , vol.30 , pp. 1953-1959
    • Lonial, S.1    Vij, R.2    Harousseau, J.L.3
  • 23
    • 84879565775 scopus 로고    scopus 로고
    • Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: Interim results of a phase 2 study
    • P.G. Richardson, P. Moreau, A.J. Jakubowiak, and et al. Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: interim results of a phase 2 study Blood 120 2012 202
    • (2012) Blood , vol.120 , pp. 202
    • Richardson, P.G.1    Moreau, P.2    Jakubowiak, A.J.3
  • 24
    • 84890560780 scopus 로고    scopus 로고
    • Phase I/II dose-escalation study of daratumumab in patients with relapsed or refractory multiple myeloma
    • (abstract 8512)
    • H. Lokhorst, T. Plesner, P. Gimsing, and et al. Phase I/II dose-escalation study of daratumumab in patients with relapsed or refractory multiple myeloma J Clin Oncol 31 suppl 2013 (abstract 8512)
    • (2013) J Clin Oncol , vol.31
    • Lokhorst, H.1    Plesner, T.2    Gimsing, P.3
  • 25
    • 84893283922 scopus 로고    scopus 로고
    • Preliminary safety and efficacy data of daratumumab in combination with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma
    • T. Plesner, T. Arkenau, H. Lorkhorst, and et al. Preliminary safety and efficacy data of daratumumab in combination with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma Blood 122 2013 1986
    • (2013) Blood , vol.122 , pp. 1986
    • Plesner, T.1    Arkenau, T.2    Lorkhorst, H.3
  • 26
    • 84905453261 scopus 로고    scopus 로고
    • SAR650984, A CD38 monoclonal antibody in patients with selected CD38+ hematological malignancies - Data from a dose-escalation phase i study
    • T.G. Martin, S.A. Strickland, M. Glenn, and et al. SAR650984, A CD38 monoclonal antibody in patients with selected CD38+ hematological malignancies - data from a dose-escalation phase I study Blood 122 2013 284
    • (2013) Blood , vol.122 , pp. 284
    • Martin, T.G.1    Strickland, S.A.2    Glenn, M.3
  • 27
    • 69349097803 scopus 로고    scopus 로고
    • Phase i study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma
    • A. Badros, A.M. Burger, S. Phillip, and et al. Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma Clin Cancer Res 15 2009 5250 5257
    • (2009) Clin Cancer Res , vol.15 , pp. 5250-5257
    • Badros, A.1    Burger, A.M.2    Phillip, S.3
  • 28
    • 84867422068 scopus 로고    scopus 로고
    • Phase i trial of vorinostat combined with bortezomib for the treatment of relapsing and/or refractory multiple myeloma
    • D.M. Weber, T. Graef, M. Hussein, and et al. Phase I trial of vorinostat combined with bortezomib for the treatment of relapsing and/or refractory multiple myeloma Clin Lymphoma Myeloma Leuk 12 2012 319 324
    • (2012) Clin Lymphoma Myeloma Leuk , vol.12 , pp. 319-324
    • Weber, D.M.1    Graef, T.2    Hussein, M.3
  • 29
    • 84876452938 scopus 로고    scopus 로고
    • PANORAMA 2: Panobinostat combined with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory multiple myeloma
    • P.G. Richardson, M. Alsina, D. Weber, and et al. PANORAMA 2: panobinostat combined with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory multiple myeloma Blood 120 2012 1852
    • (2012) Blood , vol.120 , pp. 1852
    • Richardson, P.G.1    Alsina, M.2    Weber, D.3
  • 30
    • 84886919481 scopus 로고    scopus 로고
    • Phase III study of panobinostat with bortezomib and dexamethasone in patients with relapsed multiple myeloma (PANORAMA 1)
    • J.F. San-Miguel, P. Moreau, S.-S. Yoon, and et al. Phase III study of panobinostat with bortezomib and dexamethasone in patients with relapsed multiple myeloma (PANORAMA 1) J Clin Oncol 30 2012 e18572
    • (2012) J Clin Oncol , vol.30 , pp. e18572
    • San-Miguel, J.F.1    Moreau, P.2    Yoon, S.-S.3
  • 31
    • 84879592293 scopus 로고    scopus 로고
    • Rocilinostat (ACY-1215), a selective HDAC6 inhibitor, alone and in combination with bortezomib in multiple myeloma: Preliminary results from the first-in-humans phase I/II study
    • N. Raje, P.N. Hari, D.T. Vogl, and et al. Rocilinostat (ACY-1215), a selective HDAC6 inhibitor, alone and in combination with bortezomib in multiple myeloma: preliminary results from the first-in-humans phase I/II study Blood 121 2012 4061
    • (2012) Blood , vol.121 , pp. 4061
    • Raje, N.1    Hari, P.N.2    Vogl, D.T.3
  • 32
    • 84904054553 scopus 로고    scopus 로고
    • ACY-1215, a selective histone deacetylase (HDAC) 6 inhibitor, in combination with lenalidomide and dexamethasone (Dex), is well tolerated without dose limiting toxicity (DLT) in patients (pts) with multiple myeloma (MM) at doses demonstrating biologic activity: Interim results of a phase 1b trial
    • A. Yee, P. Voorhees, W.I. Bensinger, and et al. ACY-1215, a selective histone deacetylase (HDAC) 6 inhibitor, in combination with lenalidomide and dexamethasone (Dex), is well tolerated without dose limiting toxicity (DLT) In patients (pts) with multiple myeloma (MM) at doses demonstrating biologic activity: interim results of a phase 1b trial Blood 122 2013 3190
    • (2013) Blood , vol.122 , pp. 3190
    • Yee, A.1    Voorhees, P.2    Bensinger, W.I.3
  • 33
    • 84890568547 scopus 로고    scopus 로고
    • Weekly MLN9708, an investigational oral proteasome inhibitor, in relapsed/refractory multiple myeloma: Results from a phase i study after full enrollment
    • S. Kumar, W.I. Bensinger, T.M. Zimmerman, and et al. Weekly MLN9708, an investigational oral proteasome inhibitor, in relapsed/refractory multiple myeloma: results from a phase I study after full enrollment J Clin Oncol 31 2013 8514
    • (2013) J Clin Oncol , vol.31 , pp. 8514
    • Kumar, S.1    Bensinger, W.I.2    Zimmerman, T.M.3
  • 34
    • 84906056010 scopus 로고    scopus 로고
    • Clinical profile of single-agent modified-release oprozomib tablets in patients (pts) with hematologic malignancies: Updated results from a multicenter, open-label, dose escalation phase 1b/2 study
    • I.M. Ghobrial, J.L. Kaufman, D.S. Siegel, and et al. Clinical profile of single-agent modified-release oprozomib tablets in patients (pts) with hematologic malignancies: updated results from a multicenter, open-label, dose escalation phase 1b/2 study Blood 122 2013 3184
    • (2013) Blood , vol.122 , pp. 3184
    • Ghobrial, I.M.1    Kaufman, J.L.2    Siegel, D.S.3
  • 35
    • 84905491925 scopus 로고    scopus 로고
    • Prolonged survival and improved response rates with ARRY-520 in relapsed/refractory multiple myeloma (RRMM) patients with low α-1 acid glycoprotein (AAG) levels: Results from a phase 2 study
    • S. Lonial, J.J. Shah, J. Zonder, and et al. Prolonged survival and improved response rates with ARRY-520 in relapsed/refractory multiple myeloma (RRMM) patients with low α-1 acid glycoprotein (AAG) levels: results from a phase 2 study Blood 122 2013 285
    • (2013) Blood , vol.122 , pp. 285
    • Lonial, S.1    Shah, J.J.2    Zonder, J.3
  • 36
    • 84912547554 scopus 로고    scopus 로고
    • A phase 1 study of ARRY-520 with bortezomib (BTZ) and dexamethasone (Dex) in relapsed or refractory multiple myeloma (RRMM)
    • A. Chari, M. Hatut, J. Zonder, and et al. A phase 1 study of ARRY-520 with bortezomib (BTZ) and dexamethasone (Dex) in relapsed or refractory multiple myeloma (RRMM) Blood 122 2013 1938
    • (2013) Blood , vol.122 , pp. 1938
    • Chari, A.1    Hatut, M.2    Zonder, J.3
  • 37
    • 84906056319 scopus 로고    scopus 로고
    • Phase 1 study of the novel kinesin spindle protein inhibitor ARRY-520 + carfilzomib (Car) in patients with relapsed and/or refractory multiple myeloma (RRMM)
    • J.J. Shah, L. Feng, S.K. Thomas, and et al. Phase 1 study of the novel kinesin spindle protein inhibitor ARRY-520 + carfilzomib (Car) in patients with relapsed and/or refractory multiple myeloma (RRMM) Blood 122 2013 1982
    • (2013) Blood , vol.122 , pp. 1982
    • Shah, J.J.1    Feng, L.2    Thomas, S.K.3


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