Selection of empirical antibiotics for health care-associated pneumonia via integration of pneumonia severity index and risk factors of drug-resistant pathogens

Journal of the Formosan Medical Association

Volumn 115, Issue 5, 2016, Pages 356-363

  Wang, Ping Huai ^a   Wang, Hao Chien ^b   Cheng, Shih Lung ^a   Chang, Hou Tai ^a   Laio, Chun Hsing ^a  

^a FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Drug resistance; Health care facility; Mortality; Pneumonia; Pneumonia severity

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ADULT; AGED; ALGORITHM; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BRONCHIECTASIS; FEMALE; HEALTH CARE ASSOCIATED PNEUMONIA; HOSPITAL MORTALITY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; NONHUMAN; NOSE FEEDING; OBSERVATIONAL STUDY; PNEUMONIA SEVERITY INDEX; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; RISK FACTOR; WOUND CARE; CROSS INFECTION; ODDS RATIO; PNEUMONIA, BACTERIAL; PSEUDOMONAS INFECTIONS; RECEIVER OPERATING CHARACTERISTIC; SEVERITY OF ILLNESS INDEX; STAPHYLOCOCCAL INFECTIONS; TAIWAN; TERTIARY CARE CENTER; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; ODDS RATIO; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RETROSPECTIVE STUDIES; RISK FACTORS; ROC CURVE; SEVERITY OF ILLNESS INDEX; STAPHYLOCOCCAL INFECTIONS; TAIWAN; TERTIARY CARE CENTERS;

EID: 84928634722     PISSN: 09296646     EISSN: 18760821     Source Type: Journal    
DOI: 10.1016/j.jfma.2015.03.009     Document Type: Article

References (30)

1. Bartlett J.G., Dowell S.F., Mandell L.A., File T.M., Musher D.M., Fine M.J. Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Diseases Society of America. Clin Infect Dis 2000, 31:347-382.
2. Anon Hospital-acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy, and preventive strategies. A consensus statement, American Thoracic Society, November 1995. Am J Respir Crit Care Med 1996, 153:1711-1725. American Thoracic Society.
3. Arancibia F., Bauer T.T., Ewig S., Mensa J., Gonzalez J., Niederman M.S., et al. Community-acquired pneumonia due to gram-negative bacteria and Pseudomonas aeruginosa: incidence, risk and prognosis. Arch Intern Med 2002, 162:1849-1858.
4. Pop-Vicas A.E., D'Agata E.M. The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital. Clin Infect Dis 2005, 40:1792-1798.
5. El-Solh A.A., Aquilina A.T., Dhillon R.S., Ramadan F., Nowak P., Davies J. Impact of invasive strategy on management of antimicorbial treatment failure in institutionalized older people with severe pneumonia. Am J Repir Crit Care Med 2002, 166:1038-1043.
6. American Thoracic Society, Infectious Disease Society of America Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Repir Crit Care Med 2005, 171:388-416.
7. Brito V., Niederman M.S. Healthcare-associated pneumonia is a heterogeneous disease, and all patients do not need the same broad-spectrum antibiotic therapy as complex nosocomial pneumonia. Curr Opin Infect Dis 2009, 22:316-325.
8. Aliberti S., Di Pasquale M., Zanaboni A.M., Cosentini R., Brambilla A.M., Seghezzi S., et al. Stratifying risk factors for multidrug-resistant pathogens in hospitalized patients coming from the community with pneumonia. Clin Infect Dis 2012, 54:470-478.
9. Shindo Y., Ito R., Kobayashi D., Ando M., Ichikawa M., Shiraki A., et al. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. Am J Respir Crit Care Med 2013, 188:985-995.
10. El Solh A.A., Pietrantoni C., Bhat A., Bhora M., Berbary E. Indicators of potentially drug-resistant bacteria in severe nursing home-acquired pneumonia. Clin Infect Dis 2004, 39:474-480.
11. Renaud B., Coma E., Labarere J., Hayon J., Roy P.M., Boureaux H., et al. Routine use of the Pneumonia Severity Index for guiding the site-of-treatment decision of patients with pneumonia in the emergency department: a multicenter, prospective, observational, controlled cohort study. Clin Infect Dis 2007, 44:41-49.
12. Mandell L.A., Wunderink R.G., Anzueto A., Bartlett J.G., Campbell G.D., Dean N.C., et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007, 44:S27-72.
13. Carrabba M., Zarantonello M., Bonara P., Hu C., Minonzio F., Cortinovis I., et al. Severity assessment of healthcare-associated pneumonia and pneumonia in immunosuppression. Eur Respir J 2012, 40:1201-1210.
14. Jeong B.H., Koh W.J., Yoo H., Um S.W., Suh G.Y., Chung M.P., et al. Performances of prognostic scoring systems in patients With healthcare-associated pneumonia. Clin Infect Dis 2013, 56:625-632.
15. Micek S.T., Kollef K.E., Reichley R.M., Roubinian N., Kollef M.H. Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother 2007, 51:3568-3573.
16. Fine M.J., Auble T.E., Yealy D.M., Hanusa B.H., Weissfeld L.A., Singer D.E., et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997, 336:243-250.
17. Kollef M.H., Shorr A., Tabak Y.P., Gupta V., Liu L.Z., Johannes R.S. Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest 2005, 128:3854-3862.
18. Carratala J., Mykietiuk A., Fernandez-Sabe N., Suarez C., Dorca J., Verdaguer R., et al. Health care-associated pneumonia requiring hospital admission: epidemiology, antibiotic therapy, and clinical outcomes. Arch Intern Med 2007, 167:1393-1399.
19. Wu C.L., Ku S.C., Yang K.Y., Fang W.F., Tu C.Y., Chen C.W., et al. Antimicrobial drug-resistant microbes associated with hospitalized community-acquired and healthcare-associated pneumonia: a multi-center study in Taiwan. J Formos Med Assoc 2013, 112:31-40.
20. Fang W.F., Yang K.Y., Wu C.L., Yu C.J., Chen C.W., Tu C.Y., et al. Application and comparison of scoring indices to predict outcomes in patients with healthcare associated pneumonia. Crit Care 2011, 15:R32.
21. Falcone M., Corrao S., Venditti M., Serra P., Licata G. Performance of PSI, CURB-65, and SCAP scores in predicting the outcome of patients with community-acquired and healthcare-associated pneumonia. Intern Emerg Med 2011, 6:43-46.
22. Shorr A.F., Zilberberg M.D., Micek S.T., Kollef M.H. Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med 2008, 168:2205-2210.
23. Maruyama T., Fujisawa T., Okuno M., Toyoshima H., Tsutsui K., Maeda H., et al. A new strategy for healthcare-associated pneumonia: a 2-year prospective multicenter cohort study using risk factors for multidrug-resistant pathogens to select initial empiric therapy. Clin Infect Dis 2013, 57:1373-1383.
24. Shindo Y., Sato S., Maruyama E., Ohashi T., Ogawa M., Hashimoto N., et al. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital. Chest 2009, 135:633-640.
25. Ewig S., Welte T., Chastre J., Torres A. Rethinking the concepts of community-acquired and health-care-associated pneumonia. Lancet Infect Dis 2010, 10:279-287.
26. Houck P.M., Bratzler D.W., Nsa W., Ma A., Bartlett J.G. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med 2004, 164:637-644.
27. Chalmers J.D., Taylor J.K., Singanayagam A., Fleming G.B., Akram A.R., Mandal P., et al. Epidemiology, antibiotic therapy, and clinical outcomes in health care-associated pneumonia: a UK cohort study. Clin Infect Dis 2011, 53:107-113.
28. Rello J., Lujan M., Gallego M., Valles J., Belmonte Y., Fontanals D., et al. Why mortality is increased in health-care-associated pneumonia: lessons from pneumococcal bacteremic pneumonia. Chest 2010, 137:1138-1144.
29. Labelle A.J., Arnold H., Reichley R.M., Micek S.T., Kollef M.H. A comparison of culture-positive and culture-negative health-care-associated pneumonia. Chest 2010, 137:1130-1137.
30. Nicolle L.E., McLeod J., McIntyre M., MacDonell J.A. Significance of pharyngeal colonization with aerobic gram-negative bacilli in elderly institutionalized men. Age Ageing 1986, 15:47-52.