The association between Vitamin D levels and urinary tract infection in children

Hormone Research in Paediatrics

Volumn 83, Issue 3, 2015, Pages 198-203

  Tekin, Mehmet ^a   Konca, Capan ^a   Celik, Velat ^a   Almis, Habip ^a   Kahramaner, Zelal ^a   Erdemir, Aydin ^a   Gulyuz, Abdulgani ^b   Uckardes, Fatih ^a   Turgut, Mehmet ^a  

^a ADIYAMAN UNIVERSITY   (Turkey)

^b Sevgi Hospital   (Turkey)

Author keywords

25 hydroxyvitamin D; Children; Urinary tract infection; Vitamin D deficiency

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; C REACTIVE PROTEIN; CALCIUM; PARATHYROID HORMONE; PHOSPHORUS; CALCIFEDIOL;

ACUTE PYELONEPHRITIS; ANOREXIA; ARTICLE; CALCIUM BLOOD LEVEL; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSURIA; ESCHERICHIA COLI INFECTION; FEMALE; FEVER; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROSPECTIVE STUDY; URINARY TRACT INFECTION; VITAMIN BLOOD LEVEL; BLOOD; INFANT; METABOLISM; PRESCHOOL CHILD; PYELONEPHRITIS; SEX DIFFERENCE;

ALKALINE PHOSPHATASE; C-REACTIVE PROTEIN; CALCIFEDIOL; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LEUKOCYTE COUNT; MALE; PARATHYROID HORMONE; PROSPECTIVE STUDIES; PYELONEPHRITIS; SEX FACTORS; URINARY TRACT INFECTIONS;

EID: 84928620911     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000370046     Document Type: Article

References (31)

1. Rushton HG: Urinary tract infections in children. Epidemiology, evaluation, and management. Pediatr Clin North Am 1997; 44: 1133-1169
2. Zorc JJ, Levine DA, Platt SL, Dayan PS, Macias CG, Krief W, Schor J, Bank D, Shaw KN, Kuppermann N; Multicenter RSV-SBI Study Group of the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics: Clinical and demographic factors associated with urinary tract infection in young febrile infants. Pediatrics 2005; 116; 644-648
3. Hoberman A, Wald ER, Hickey RW, Baskin M, Charron M, Majd M, Kearney DH, Reynolds EA, Ruley J, Janosky JE: Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics 1999; 104: 79-86
4. Smellie JM, Barratt TM, Chantler C, Gordon I, Prescod NP, Ransley PG, Woolf AS: Medical versus surgical treatment in children with severe bilateral vesicoureteric reflux and bilateral nephropathy: a randomised trial. Lancet 2001; 357: 1329-1333
5. Mingin GC, Hinds A, Nguyen HT, Baskin LS: Children with a febrile urinary tract infection and a negative radiologic workup: factors predictive of recurrence. Urology 2004; 63: 562-565
6. Finer G, Landau D: Pathogenesis of urinary tract infections with normal female anatomy. Lancet Infect Dis 2004; 4: 631-635
7. Wang TT, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, Tavera-Mendoza L, Lin R, Hanrahan JW, Mader S, White JH: Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004; 173: 2909-2912
8. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL: Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311: 1770-1773
9. Aydn S, Aslan I, Yldz I, Aaçhan B, Topta B, Toprak S, Deer K, Oktay MF, Unüvar E: Vitamin D levels in children with recurrent tonsillitis. Int J Pediatr Otorhinolaryngol 2011; 75: 364-367
10. Watkins RR, Yamshchikov AV, Lemonovich TL, Salata RA: The role of vitamin D deficiency in sepsis and potential therapeutic implications. J Infect 2011; 63: 321-326
11. Leow L, Simpson T, Cursons R, Karalus N, Hancox RJ: Vitamin D, innate immunity and outcomes in community acquired pneumonia. Respirology 2011; 16: 611-616
12. Juzeniene A, Ma LW, Kwitniewski M, Polev GA, Lagunova Z, Dhalback A: The seasonality of pandemic and non-pandemic influenzas: the roles of solar radiation and vitamin D. Int J Infect Dis 2010; 14: 1099-1105
13. Bitsori M, Galanakis E: Pediatric urinary tract infections: diagnosis and treatment. Expert Rev Anti Infect Ther 2012; 10: 1153-1164
14. Shaikh N, Ewing AL, Bhatnagar S, Hoberman A: Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics 2010; 126: 1084-1091
15. La Scola C, De Mutiis C, Hewitt IK, Puccio G, Toffolo A, Zucchetta P, Mencarelli F, Marsciani M, Dall'Amico R, Montini G: Different guidelines for imaging after first UTI in febrile infants: yield, cost, and radiation. Pediatrics 2013; 131: 665-667
16. Chesney RW: Vitamin D and the magic mountain: the antiinfectious role of the vitamin. J Pediatr 2010; 156: 698-703
17. Bikle DD: Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens 2008; 17: 348-352
18. Mahon BD, Wittke A, Weaver V, Cantorna MT: The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 2003; 89: 922-932
19. Adorini L, Penna G: Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum Immunol 2009; 70: 345-352
20. Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML: Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 2010; 5: 11088
21. Nseir W, Mograbi J, Abu-Rahmeh Z, Mahamid M, Abu-Elheja O, Shalata A: The association between vitamin D levels and recurrent group A streptococcal tonsillopharyngitis in adults. Int J Infect Dis 2012; 16: 735-738
22. Jeon K, Kim SY, Jeong BH, Chang B, Shin SJ, Koh WJ: Severe vitamin D deficiency is associated with non-tuberculous mycobacterial lung disease: a case-control study. Respirology 2013; 18: 983-988
23. Raffi HS, Bates JM, Laszik Z, Kumar S: Tamm-Horsfall protein acts as a general host-defense factor against bacterial cystitis. Am J Nephrol 2005; 25: 570-578
24. Chromek M, Slamová Z, Bergman P, Kovács L, Podracká L, Ehrén I, Hökfelt T, Gudmundsson GH, Gallo RL, Agerberth B, Brauner A: The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med 2006; 12: 636-641
25. Bartley J: Vitamin D: emerging roles in infection and immunity. Expert Rev Anti Infect Ther 2010; 8: 1359-1369
26. Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G: Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). J Cyst Fibros 2007; 6: 403-410
27. Hertting O, Holm A, Lüthje P, Brauner H, Dyrdak R, Jonasson AF, Wiklund P, Chromek M, Brauner A: Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One 2010; 5: 15580
28. Aslan S, Akil I, Aslan G, Onay H, Ozyurt BC, Ozkinay F: Vitamin D receptor gene polymorphism in children with urinary tract infection. Pediatr Nephrol 2012; 27: 417-421
29. Nseir W, Taha M, Nemarny H, Mograbi J: The association between serum levels of vitamin D and recurrent urinary tract infections in premenopausal women. Int J Infect Dis 2013; 17: 1121-1124
30. Gürgöze MK, Akarsu S, Yilmaz E, Gödekmerdan A, Akça Z, Ciftçi I, Aygün AD: Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis. Pediatr Nephrol 2005; 20: 1445-1448
31. Ayazi P, Mahyar A, Daneshi MM, Jahani Hashemi H, Pirouzi M, Esmailzadehha N: Diagnostic accuracy of the quantitative C-reactive protein, erythrocyte sedimentation rate and white blood cell count in urinary tract infections among infants and children. Malays J Med Sci 2013; 20: 40-46.